Database Query Results : , , miR-142-3p

miR-142-3p, miR-142-3p microRNA: Click to Expand ⟱

Source:

Type:

miR-142-3p is a microRNA (miRNA) that has been found to play a role in various types of cancer. MicroRNAs are small non-coding RNAs that regulate gene expression by binding to messenger RNA (mRNA) molecules and preventing them from being translated into proteins.
Studies have shown that miR-142-3p can act as both a tumor suppressor and an oncogene, depending on the type of cancer. For example, in some types of leukemia, miR-142-3p is overexpressed and functions as an oncogene, promoting the growth and survival of cancer cells. On the other hand, in other types of cancer such as colorectal cancer and hepatocellular carcinoma, miR-142-3p is downregulated and functions as a tumor suppressor, inhibiting the growth and survival of cancer cells.

Scientific Papers found: Click to Expand⟱

415-

CUR,

Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142-3p/PSMB5 axis

vitro+vivo,

BC,

MDA-MB-231

5, 10, 20 and 50 μM, 24 h; 25 g/kg, 4 weeks

mice

PSMB5↓, CT-I↓, miR-142-3p↑, EP300↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

PSMB5↓, 1,

Proliferation, Differentiation & Cell State ⓘ

EP300↓, 1, miR-142-3p↑, 1,

Drug Metabolism & Resistance ⓘ

CT-I↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-142-3p, miR-142-3p microRNA

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells