Database Query Results : , , miR-29b

miR-29b, miR-29b: Click to Expand ⟱
Source:
Type:
miR-29b is a microRNA that has been extensively studied for its role in cancer. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or inhibition of translation.

miR-29b has been found to act as a tumor suppressor in various types of cancer, including lung, breast, colon, and liver cancer. It targets several genes involved in cell proliferation, apoptosis, and metastasis, including:
-Collagen genes (COL1A1, COL1A2, COL3A1), which are involved in tumor cell invasion and metastasis.
-Cell cycle regulators (CDK6, CCND1), which promote cell proliferation.
-Anti-apoptotic genes (MCL1, BCL2), which inhibit programmed cell death.
-Epithelial-to-mesenchymal transition (EMT) regulators (ZEB1, ZEB2), which promote tumor cell migration and invasion.

Downregulation of miR-29b has been observed in various cancers, and this downregulation is often associated with poor prognosis and aggressive tumor behavior. Conversely, overexpression of miR-29b has been shown to inhibit tumor growth, induce apoptosis, and suppress metastasis in cancer cells.
Scientific Papers found: Click to Expand⟱
4820- ASTX,    Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p
- in-vitro, NPC, NA
TumCP↓, TumCI↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, Bcl-2↓, P21↑, BAX↑, PI3K↓, Akt↓, NF-kB↓, miR-29b↑,
4812- ASTX,    Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a
- in-vitro, CRC, HCT116
miR-29b↑, miR-200b↑, MMP2↓, Zeb1↓, EMT↓, Apoptosis↑, ERK↓, MAPK↓, PI3K↓, Akt↓, MMPs↓, TumMeta↓,
422- CUR,    Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines
- in-vitro, BC, HCC-38 - in-vitro, BC, T47D
BRCA1↑, TET1↑, DNMT3A↑, DNMT1↓, SNCG↓, miR-29b↓, miR-29b↑,
2985- RES,    Resveratrol Inhibits Diabetic-Induced Müller Cells Apoptosis through MicroRNA-29b/Specificity Protein 1 Pathway
- in-vivo, Nor, NA - vitro+vivo, Diabetic, NA
*Sp1/3/4↓, *miR-29b↑,
3430- TQ,    Targeting microRNAs with thymoquinone: a new approach for cancer therapy
- Review, Var, NA
miR-29b↑, Sp1/3/4↓, TumCG↓, Rac1↓, angioG↓, TumMeta↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   MAPK↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   DNMT1↓, 1,   DNMT3A↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   PI3K↓, 2,   TumCG↓, 1,  

Migration ⓘ

miR-200b↑, 1,   miR-29b↓, 1,   miR-29b↑, 4,   MMP2↓, 1,   MMPs↓, 1,   Rac1↓, 1,   TET1↑, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 2,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Protein Aggregation ⓘ

SNCG↓, 1,  

Clinical Biomarkers ⓘ

BRCA1↑, 1,  
Total Targets: 31

Pathway results for Effect on Normal Cells:


Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Migration ⓘ

miR-29b↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: miR-29b, miR-29b
2 Astaxanthin
1 Curcumin
1 Resveratrol
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:658  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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