Database Query Results : , , PAO

PAO, PAO gene: Click to Expand ⟱
Source:
Type:
The PAO gene, also known as the polyamine oxidase gene, is a gene that encodes for the enzyme polyamine oxidase. This enzyme is involved in the breakdown of polyamines, which are small molecules that play a crucial role in various cellular processes, including cell growth, differentiation, and survival.

The PAO gene is located on chromosome 10q23 in humans and is composed of 10 exons. The gene is highly conserved across different species, suggesting its importance in maintaining cellular homeostasis.
Overexpressed: Breast, Lung, Colon
Underexpressed: Prostate, Ovarian

PAO (Polyamine Oxidase) catalyzes the oxidation of polyamines (e.g., N^1-acetylspermine) leading to products including H₂O₂, which is an ROS capable of promoting DNA damage.

PAO inhibitors are being studied for their potential to modulate oxidative stress and affect polyamine balances in tumors, although this work is still largely in the early stages.

In summary, while the PAO gene product—polyamine oxidase—is generally reported to be upregulated or more active in several tumor types (such as prostate, colorectal, and some breast cancers) and is associated with mechanisms that may promote tumor progression (for example, by generating oxidative stress), the literature is still evolving.
Scientific Papers found: Click to Expand⟱
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

PAO↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

p‑p42↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

SSAT↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Bak↑, 1,   Bcl-2↓, 1,   Mcl-1↓, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PIAS-3↑, 1,   RAS↓, 1,   Src↓, 1,   p‑STAT1↓, 1,  

Migration ⓘ

p‑p44↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PAO, PAO gene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:664  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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