Database Query Results : , , SSAT

SSAT, Spermidine/Spermine N1-Acetyltransferase: Click to Expand ⟱
Source:
Type: gene
SSAT gene (Spermidine/Spermine N1-Acetyltransferase) is a gene that encodes an enzyme involved in the regulation of polyamine metabolism. Polyamines, such as spermidine and spermine, are small molecules that play a crucial role in various cellular processes, including cell growth, proliferation, and differentiation.

The SSAT enzyme is responsible for the acetylation of spermidine and spermine, which is a key step in the degradation of these polyamines. The SSAT gene is located on chromosome 2q31.1 and is expressed in various tissues, including the liver, kidney, and brain.

Dysregulation of the SSAT gene has been implicated in various diseases, including cancer.
Overexpression of the SSAT gene has been observed in certain types of cancer, such as breast, prostate, and colon cancer.
Overexpression: Breast, Prostate, Colon
Underexpressed: Ovarian, lung
Scientific Papers found: Click to Expand⟱
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

PAO↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

p‑p42↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

SSAT↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Bak↑, 1,   Bcl-2↓, 1,   Mcl-1↓, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PIAS-3↑, 1,   RAS↓, 1,   Src↓, 1,   p‑STAT1↓, 1,  

Migration ⓘ

p‑p44↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SSAT, Spermidine/Spermine N1-Acetyltransferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:665  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page