Database Query Results : , , ITGB1

ITGB1, Integrin beta-1: Click to Expand ⟱
Source:
Type:
ITGB1, also known as Integrin beta-1 or β1-integrin, is a protein that plays a crucial role in cell adhesion, migration, and signaling. It is a transmembrane receptor that interacts with various extracellular matrix proteins, such as collagen, laminin, and fibronectin.
ITGB1 is overexpressed in: breast, lung, colon, prostate, CRC, ovarian, pancreatic, gastric, esophageal, melanoma, GBM
Scientific Papers found: Click to Expand⟱
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
295- ALA,    α-Lipoic acid suppresses migration and invasion via downregulation of cell surface β1-integrin expression in bladder cancer cells
- in-vitro, Bladder, T24
ITGB1↓, TumCMig↓, ERK↓, Akt↓,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
3178- Ash,    Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis
- Review, Nor, NA
ITGB1↓,
2714- BBR,    Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
AMPK↑, ITGB1↓,
733- Bor,    The analysis of boric acid effect on epithelial-mesenchymal transition of CD133 + CD117 + lung cancer stem cells
- in-vitro, Lung, NA
Snail↑, ITGB1↑, ITGA5↑, COL1A1↓, LAMA5↑, MMP3↓, Vim↓, E-cadherin↑, EMT↓, Zeb1↑,
756- Bor,    Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
COL1A1↓, Vim↓, miR-127-5p↑, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑,
736- Bor,    Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
miR-126↑, COL1A1↓, Vim↓, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑, miR-127-5p↑,
427- CUR,    Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460 - vitro+vivo, Lung, A549
ITGB1↓, circ-PRKCA↓, miR-384↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
1714- Lyco,    Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
- in-vitro, Ovarian, OV-MZ-6 - in-vivo, NA, NA
ChemoSen↑, CA125↓, ITGA5↓, ITGB1↓, MMP9↓, FAK↓, EMT↓, MAPK↓, MMP9↓, antiOx↑, Ki-67↓, MAPK↓,
3482- MF,    Pulsed Electromagnetic Fields Increase Angiogenesis and Improve Cardiac Function After Myocardial Ischemia in Mice
- in-vitro, NA, NA
*cardioP↑, *VEGF↑, *VEGFR2↑, *Hif1a↑, *FGF↑, *ITGB1↑, *angioG↑,
3481- MF,    No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell lines
- in-vitro, OS, MG63 - in-vitro, OS, SaOS2
ITGA1∅, ITGB1∅, ITGA5∅, ITGB3∅, ITGB4∅, MMP2∅, MMP9∅, eff↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4967- PSO,    Psoralidin's Anti-Cancer Mechanisms: A Technical Guide
- Review, Var, NA
NF-kB↓, PI3K↓, Akt↓, ITGB1↓, FAK↓, BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, DR5↑, TumCCA↑, TumAuto↑, TumMeta↓,
3081- RES,    Resveratrol and p53: How are they involved in CRC plasticity and apoptosis?
- Review, CRC, NA
NF-kB↓, FAK↓, Ki-67↓, MMP9↓, CSCs↓, CD44↓, CD133↓, ALDH1A1↓, EMT↓, ChemoSen↑, Hif1a↓, ITGB1↓, Inflam↓,
3190- SFN,    Sulforaphane inhibits TGF-β-induced fibrogenesis and inflammation in human Tenon’s fibroblasts
- in-vitro, Nor, NA
*Fibronectin↓, *α-SMA↓, *ITGB1↓, *ITGA5↓, *IL6↓, *IL8↓, Inflam↓,
3046- SK,    Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway
- in-vitro, Lung, A549
TumCP↓, TumCI↓, TumCMig↓, p‑ERK↓, ITGB1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   Ferroptosis↑, 1,   frataxin↑, 1,   GPx↓, 1,   GSH↓, 4,   GSR↓, 1,   GSTs↓, 1,   HO-1↓, 1,   NQO1↓, 1,   NRF2↓, 1,   NRF2↑, 1,   NRF2↝, 1,   ROS↑, 4,   SOD↓, 1,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 1,   OCR↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 1,   CYP3A4↓, 1,   Glycolysis↓, 1,   NADPH↓, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 5,   p‑Akt↓, 2,   Apoptosis↑, 4,   BAX↑, 2,   BAX↝, 1,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp1↓, 1,   Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 1,   p‑Chk2↑, 1,   Cyt‑c↑, 2,   DR4↑, 1,   DR5↑, 2,   Fas↑, 2,   FasL↑, 1,   Ferroptosis↑, 1,   HGF/c-Met↓, 1,   p‑JNK↑, 1,   MAPK↓, 3,   Mcl-1↓, 1,   p‑MDM2↓, 1,   miR-127-5p↑, 2,   oncosis↑, 1,   p27↑, 1,   p‑p38↑, 1,   survivin↓, 3,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,   H4↓, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   p‑CHK1↑, 1,   DNAdam↑, 1,   HR↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↑, 2,   P53↝, 1,   PARP↑, 1,   PCNA↓, 1,   RAD51↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   cycE1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD133↓, 1,   CD34↓, 1,   CD44↓, 1,   cFos↑, 1,   cMET↓, 1,   CSCs↓, 1,   EMT↓, 7,   ERK↓, 4,   p‑ERK↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   mTOR↓, 2,   NOTCH1↓, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   PTEN↓, 1,   p‑Src↓, 1,   STAT3↓, 2,   p‑STAT6↓, 1,   TumCG↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AXL↓, 1,   Cdc42↓, 1,   CDH1↑, 2,   CDK4/6↓, 1,   CEA↓, 1,   circ-PRKCA↓, 1,   CLDN1↓, 1,   COL1A1↓, 3,   E-cadherin↓, 1,   E-cadherin↑, 1,   FAK↓, 6,   ITGA1∅, 1,   ITGA5↓, 2,   ITGA5↑, 3,   ITGA5∅, 1,   ITGB1↓, 12,   ITGB1↑, 4,   ITGB1∅, 1,   ITGB3↓, 1,   ITGB3∅, 1,   ITGB4∅, 1,   ITGB6↓, 1,   Ki-67↓, 2,   LAMA5↑, 3,   MET↓, 1,   p‑MET↓, 1,   miR-384↑, 1,   MMP2↓, 3,   MMP2∅, 1,   MMP3↓, 1,   MMP9↓, 5,   MMP9∅, 1,   MMPs↓, 2,   N-cadherin↓, 1,   NCAM↑, 1,   Rac1↓, 1,   Rho↓, 1,   Snail↓, 2,   Snail↑, 3,   TGF-β↓, 1,   TIMP2↑, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 2,   TumMeta↓, 2,   Tyro3↓, 1,   Vim↓, 4,   Vim↑, 1,   Zeb1↓, 1,   Zeb1↑, 3,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 2,   EGFR↑, 1,   Hif1a↓, 4,   KDR/FLK-1↓, 1,   miR-126↑, 1,   NO↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   ICAM-1↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL2↑, 1,   IL6↓, 2,   Inflam↓, 3,   MIP2↓, 1,   NF-kB↓, 7,   p‑p65↓, 1,   PD-1↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 6,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose↓, 1,   Dose↝, 1,   eff↑, 2,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   CA125↓, 1,   CEA↓, 1,   EGFR↓, 2,   EGFR↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 2,   Ki-67↓, 2,   NSE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cachexia↓, 1,   chemoP↑, 1,   Risk↓, 1,  
Total Targets: 204

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GPx1↑, 1,   GSH↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   ROS↓, 2,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Cell Death ⓘ

Casp3↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

FGF↑, 1,  

Migration ⓘ

Fibronectin↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB1↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   Hif1a↑, 1,   VEGF↑, 1,   VEGFR2↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose↝, 2,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   toxicity↝, 1,  
Total Targets: 36

Scientific Paper Hit Count for: ITGB1, Integrin beta-1
3 Boron
2 Alpha-Lipoic-Acid
2 Lycopene
2 Magnetic Fields
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Berberine
1 Curcumin
1 Luteolin
1 Phenethyl isothiocyanate
1 Psoralidin
1 Resveratrol
1 Sulforaphane (mainly Broccoli)
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:669  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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