Database Query Results : , , CREBBP

CREBBP, CREB binding protein: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
CREB-binding protein (CBP) is a multifunctional coactivator that plays a crucial role in the regulation of gene expression. It interacts with various transcription factors, including the cAMP response element-binding protein (CREB), and is involved in numerous cellular processes, such as cell growth, differentiation, and apoptosis.
CBP can act as a tumor suppressor. For example, it can mediate the transcriptional activation of genes that promote apoptosis or inhibit cell proliferation. Loss of CBP function can lead to decreased expression of these protective genes, contributing to cancer progression.
CBP interacts with several oncogenic signaling pathways, including:
Wnt/β-catenin Pathway: CBP is a coactivator for β-catenin, a key player in the Wnt signaling pathway, which is often dysregulated in cancers.
CBP is also involved in the Hedgehog signaling pathway, which is important for embryonic development and has been implicated in the growth of certain tumors.
The expression of CREB-binding protein (CBP) in cancer is complex, with both overexpression and loss of function observed in different cancer types.
Scientific Papers found: Click to Expand⟱
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Myc↓, 1,   oncosis↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CREBBP↓, 1,   mTOR↓, 1,   Wnt/(β-catenin)↑, 1,  

Migration ⓘ

E-cadherin↑, 1,   LysoPr↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Clinical Biomarkers ⓘ

Myc↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CREBBP, CREB binding protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:67  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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