Database Query Results : , , TFAP2A

TFAP2A, Transcription Factor AP-2 alpha: Click to Expand ⟱
Source:
Type: Transcription Factor
TFAP2A (Transcription Factor AP-2 alpha) is a transcription factor that plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. In the context of cancer, TFAP2A has been implicated in both tumor suppression and oncogenesis, depending on the type of cancer and the cellular context.
TFAP2A has been shown to act as a tumor suppressor in certain types of cancer, such as breast cancer, where it regulates the expression of genes involved in cell cycle arrest, apoptosis, and DNA repair.
On the other hand, TFAP2A has also been implicated in the development and progression of other types of cancer, such as melanoma, where it promotes cell proliferation, survival, and metastasis.

Transcription Factor AP-2 alpha (TFAP2A) is an important regulatory protein that plays multifaceted roles in normal development and cancer biology. Its impact on tumor progression and prognosis is complex, reflecting its ability to function as both a tumor suppressor and, in some contexts, as an oncogenic factor. Variations in its expression and activity across different cancers underscore its potential utility as a prognostic biomarker and a target for therapy.
Scientific Papers found: Click to Expand⟱
439- CUR,    Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway
- in-vitro, CRC, LGR5
Apoptosis↑, TumAuto↑, GP1BB↓, COL9A3↓, COMP↓, AGRN↓, ITGB4↓, LAMA5↓, COL2A1↓, ITGB6↓, LGR5↓, TFAP2A↓, ECM/TCF↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

COMP↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TFAP2A↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

LGR5↓, 1,  

Migration ⓘ

AGRN↓, 1,   COL2A1↓, 1,   COL9A3↓, 1,   GP1BB↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   LAMA5↓, 1,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TFAP2A, Transcription Factor AP-2 alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:694  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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