Database Query Results : , , NNMT

NNMT, Nicotinamide N-methyltransferase: Click to Expand ⟱
Source:
Type: enzyme
NNMT (Nicotinamide N-methyltransferase) is an enzyme that has been implicated in various diseases, including cancer. Research has shown that NNMT is overexpressed in several types of cancer, such as breast, lung, and colon cancer.
NNMT is involved in the metabolism of nicotinamide, a form of vitamin B3. The enzyme catalyzes the transfer of a methyl group from S-adenosylmethionine (SAMe) to nicotinamide, resulting in the formation of N-methyl nicotinamide (MNA) and S-adenosylhomocysteine (SAH).
NNMT has been shown to promote cell growth and proliferation in cancer cells.
Scientific Papers found: Click to Expand⟱
440- CUR,    Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, HT-29
NNMT↓, p‑STAT3↓, TumCP↓, TumCCA↑, ROS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

NNMT↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑STAT3↓, 1,  

Migration ⓘ

TumCP↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NNMT, Nicotinamide N-methyltransferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:695  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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