Database Query Results : , , NKD2

NKD2, Naked cuticle homolog 2: Click to Expand ⟱
Source:
Type: protein
NKD2 is a negative regulator of the Wnt/β-catenin signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival.
NKD2 has been identified as a tumor suppressor gene, and its expression is often downregulated in various types of cancer: CRC, breast, lung, Prostate, ovarian.
Scientific Papers found: Click to Expand⟱
449- CUR,    Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a
- vitro+vivo, CRC, SW480
TumCP↓, β-catenin/ZEB1↓, TCF↓, miR-21↓, NKD2↑, miR-130a↓,
442- CUR,  5-FU,    Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress
- in-vitro, CRC, HCT116
Apoptosis↑, TumCP↓, TumCCA↑, TET1↑, NKD2↑, Wnt↓, EMT↓, Vim↑, E-cadherin↓, β-catenin/ZEB1↓, TCF↓, AXIN1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

AXIN1↓, 1,   EMT↓, 1,   NKD2↑, 2,   TCF↓, 2,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   miR-130a↓, 1,   TET1↑, 1,   TumCP↓, 2,   Vim↑, 1,   β-catenin/ZEB1↓, 2,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NKD2, Naked cuticle homolog 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:699  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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