Database Query Results : , , FoxP3+

FoxP3+, Forkhead box P3+: Click to Expand ⟱
Source:
Type:
FoxP3+ refers to cells that express the FoxP3 protein.
Immune Suppression: FOXP3+ Tregs are known for their ability to suppress immune responses. In the context of cancer, they can inhibit the activity of effector T cells and other immune cells, allowing tumors to evade immune detection.
Tumor Microenvironment: The presence of FOXP3+ Tregs in the tumor microenvironment is often associated with an immunosuppressive environment, which can facilitate tumor growth and metastasis.

FOXP3+ Tregs in Specific Cancers
Breast Cancer:
Expression: FOXP3+ Tregs are present in the tumor microenvironment.
Prognosis: High levels of FOXP3+ Tregs are often linked to better prognosis, indicating a potential anti-tumor immune response.
Lung Cancer:
Expression: FOXP3+ Tregs are found in the tumor microenvironment.
Prognosis: Increased FOXP3+ Tregs can correlate with poor prognosis, suggesting immune evasion.
So expression is high, but prognosis can vary.
Scientific Papers found: Click to Expand⟱
560- ART/DHA,    Dihydroartemisinin shift the immune response towards Th1, inhibit the tumor growth in vitro and in vivo
- in-vivo, NA, NA
IL4↓, CD4+↓, CD25+↓, FoxP3+↓, Treg lymp↓,
562- ART/DHA,    Artesunate exerts an anti-immunosuppressive effect on cervical cancer by inhibiting PGE2 production and Foxp3 expression
- in-vivo, NA, HeLa
CD4+↓, CD25+↓, FoxP3+↓, Treg lymp↓, PGE2↓, FOXP3↓, COX2↓,
561- ART/DHA,    Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4+ CD25+ FoxP3+ T reg cells in vivo
- in-vivo, NA, NA
TumCG↓, CD4+↓, CD25+↓, FoxP3+↓, IL4↑,
451- CUR,    The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancer
- vitro+vivo, HNSCC, SCC15 - vitro+vivo, HNSCC, SNU1076 - vitro+vivo, HNSCC, SNU1041
TumCMig↓, TumCG↓, PD-L1↓, PD-L2↓, Galectin-9↓, EMT↓, T-Cell↑, TILs↑, PD-1↓, TIM-3↓, CD4+↓, CD25+↓, FoxP3+↓, E-cadherin↑, CD8+↑, IFN-γ↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   TumCG↓, 2,  

Migration ⓘ

E-cadherin↑, 1,   Galectin-9↓, 1,   Treg lymp↓, 2,   TumCMig↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD25+↓, 4,   CD4+↓, 4,   COX2↓, 1,   FOXP3↓, 1,   FoxP3+↓, 4,   IFN-γ↑, 1,   IL4↓, 1,   IL4↑, 1,   PD-1↓, 1,   PD-L1↓, 1,   PD-L2↓, 1,   PGE2↓, 1,   T-Cell↑, 1,   TILs↑, 1,  

Cellular Microenvironment ⓘ

TIM-3↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FoxP3+, Forkhead box P3+
3 Artemisinin
1 Curcumin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:711  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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