Database Query Results : , , Trop2

Trop2, Trop2: Click to Expand ⟱

Source:

Type:

Trop2 is a cell surface glycoprotein that has been associated with various types of cancer. It is a member of the epithelial cell adhesion molecule (EpCAM) family and is involved in cell-cell adhesion, cell signaling, and cell migration.
Overexpressed in: breast, lung, CRC, prostate.
Trop2 has also been identified as a potential biomarker for cancer diagnosis and prognosis. Trop2 expression are associated with poor prognosis and reduced overall survival in patients with various types of cancer.

Scientific Papers found: Click to Expand⟱

459-

CUR,

Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells

in-vitro,

Bladder,

T24

10, 15, 20 and 25 µM, 48 and 72 h

in-vitro,

Bladder,

RT4

Trop2↓, Apoptosis↑, cycE1↓, p27↑, TumCCA↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, p27↑, 1,

Cell Cycle & Senescence ⓘ

cycE1↓, 1, TumCCA↑, 1,

Migration ⓘ

Trop2↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Trop2, Trop2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells