Database Query Results : , , PIK3R1

PIK3R1, PIK3R1/p85S6 Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1): Click to Expand ⟱
Source:
Type:
p85S6, also known as phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1), is a protein that plays a crucial role in the regulation of cell growth, survival, and metabolism. It is a subunit of the phosphatidylinositol 3-kinase (PI3K) enzyme, which is involved in the PI3K/AKT signaling pathway.

The PI3K/AKT pathway is a key regulator of cell proliferation, differentiation, and survival.

PIK3R1 overexpressed in: breast, lung, colon, prostate, pancreatic, liver, stomach, esophageal, head and neck, thyroid, melanoma, endometrial, cervical, bladder, RCC.
Scientific Papers found: Click to Expand⟱
463- CUR,    Curcumin induces autophagic cell death in human thyroid cancer cells
- in-vitro, Thyroid, K1 - in-vitro, Thyroid, FTC-133 - in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, 8505C
TumAuto↑, LC3II↑, Beclin-1↑, p‑p38↑, p‑JNK↑, p‑ERK↑, p62↓, p‑PDK1↓, p‑Akt↓, p‑p70S6↓, p‑PIK3R1↓, p‑S6↓, p‑4E-BP1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

p‑PDK1↓, 1,   p‑PIK3R1↓, 1,   p‑S6↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   p‑JNK↑, 1,   p‑p38↑, 1,  

Kinase & Signal Transduction ⓘ

p‑p70S6↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑4E-BP1↓, 1,   p‑ERK↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PIK3R1, PIK3R1/p85S6 Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:734  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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