Database Query Results : , , CYLD

CYLD, cylindromatosis (turban tumor syndrome): Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
CYLD (Cylindromatosis) is a gene that encodes a deubiquitinating enzyme, which plays a crucial role in various cellular processes, including the regulation of cell signaling pathways. Mutations in the CYLD gene are associated with several types of cancer, particularly those related to skin and other epithelial tissues.
Research has also indicated that CYLD may play a role in other cancers, including breast cancer and colorectal cancer. The exact mechanisms by which CYLD mutations contribute to these cancers are still being studied, but they may involve dysregulation of signaling pathways such as NF-κB and Wnt.
CYLD is primarily known as a tumor suppressor gene. Its protein product functions to remove ubiquitin from target proteins, thereby regulating various signaling pathways, including those involved in cell proliferation, apoptosis, and inflammation. Loss of CYLD function can lead to uncontrolled cell growth and tumorigenesis.
Biological Consequences of CYLD Loss
-Chronic NF-κB activation → resistance to apoptosis
-Pro-tumor inflammation → cytokine and chemokine production
-Enhanced invasion and EMT → metastatic competence
-Therapy resistance → reduced sensitivity to cytotoxic stress


Scientific Papers found: Click to Expand⟱

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CYLD, cylindromatosis (turban tumor syndrome)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:74  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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