Database Query Results : , , LAR

LAR, lactate receptor: Click to Expand ⟱
Source:
Type:
Lactate receptor is GPR81, but it is also commonly referred to as HCAR1 (Hydroxycarboxylic Acid Receptor 1) or LAR (Lactate Receptor), due to its ability to bind lactate.
-Is a G protein-coupled receptor that plays a crucial role in various physiological processes, including glucose and lipid metabolism, and inflammation.
HCAR-1 is overexpressed in various types of cancer, including breast, lung, colon, and pancreatic cancer. This overexpression is often associated with poor prognosis and reduced survival rates.
Scientific Papers found: Click to Expand⟱
466- CUR,    Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1
- in-vitro, Liver, HepG2 - in-vitro, Liver, HuT78
GlucoseCon↓, lactateProd↓, pH↑, NO↑, LAR↓, Hif1a↓, LDHA↓, MCT1↓, MDR1↓, STAT3↓, HCAR1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   lactateProd↓, 1,   LAR↓, 1,   LDHA↓, 1,  

Cell Death ⓘ

MCT1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   NO↑, 1,  

Immune & Inflammatory Signaling ⓘ

HCAR1↓, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Drug Metabolism & Resistance ⓘ

MDR1↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LAR, lactate receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:740  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page