Database Query Results : , , HCAR1

HCAR1, Hydroxycarboxylic acid receptor 1: Click to Expand ⟱
Source:
Type:
Also known as GPR81 (G protein-coupled receptor 81)
HCAR-1 is a G protein-coupled receptor that plays a role in various physiological processes, including metabolism, inflammation, and immune response.
HCAR-1 is overexpressed in certain types of cancer, such as breast, colon, and prostate cancer.
Scientific Papers found: Click to Expand⟱
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
GlucoseCon↓, lactateProd↓, ECAR↓, NO↓, ROS↑, HK2↓, PFK1↓, GAPDH↓, PKM2↓, LDHA↓, FASN↓, GLUT1↓, MCT1↓, MCT4↓, HCAR1↓, SDH↑, ChemoSen↑, ROS↑, BioAv↑, P53↑, NF-kB↓, pH↑,
466- CUR,    Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1
- in-vitro, Liver, HepG2 - in-vitro, Liver, HuT78
GlucoseCon↓, lactateProd↓, pH↑, NO↑, LAR↓, Hif1a↓, LDHA↓, MCT1↓, MDR1↓, STAT3↓, HCAR1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

SDH↑, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   FASN↓, 1,   GAPDH↓, 1,   GlucoseCon↓, 2,   HK2↓, 1,   lactateProd↓, 2,   LAR↓, 1,   LDHA↓, 2,   MCT4↓, 1,   PFK1↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

MCT1↓, 2,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   NO↓, 1,   NO↑, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

HCAR1↓, 2,   NF-kB↓, 1,  

Cellular Microenvironment ⓘ

pH↑, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   MDR1↓, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HCAR1, Hydroxycarboxylic acid receptor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:742  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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