Database Query Results : , , β-TRCP

β-TRCP, beta-transducin repeat-containing protein: Click to Expand ⟱
Source:
Type:
β-TRCP (beta-transducin repeat-containing protein) is a protein that plays a crucial role in the regulation of various cellular processes, including cell cycle progression, apoptosis, and DNA damage response. It is a component of the SCF (Skp1-Cullin-F-box) complex, a type of E3 ubiquitin ligase that targets specific proteins for degradation by the proteasome.
Overexpression of β-TRCP has been associated with poor prognosis and increased tumor aggressiveness. Elevated expression in: breast, lung, colon, prostate, ovarian, pancreatic, GBM HCC, Esophageal, Stomach.
Scientific Papers found: Click to Expand⟱
476- CUR,    The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
- in-vitro, PC, PATU-8988 - in-vitro, PC, PANC1
TumCMig↓, TumCI↓, Apoptosis↑, NEDD9↓, p‑Akt↓, p‑mTOR↓, PTEN↑, p73↑, β-TRCP↑,
1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 2,   Bax:Bcl2↑, 1,   β-TRCP↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   p73↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑GSK‐3β↓, 1,   p‑mTOR↓, 1,   PTEN↑, 1,  

Migration ⓘ

APC↑, 1,   NEDD9↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: β-TRCP, beta-transducin repeat-containing protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:751  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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