Database Query Results : , , Chk2

Chk2, Checkpoint Kinase 2: Click to Expand ⟱
Source:
Type: protein
Chk2: a protein that plays a crucial role in the regulation of the cell cycle and the response to DNA damage. It is a tumor suppressor gene that helps to prevent cancer by ensuring that cells with damaged DNA do not divide and proliferate.
Chk2 is activated in response to DNA damage, such as that caused by ionizing radiation or certain chemicals. Once activated, Chk2 phosphorylates and activates other proteins that help to repair DNA damage or induce cell death (apoptosis) if the damage is too severe.
Decreased expression or loss of function of CHK2 is often associated with more aggressive tumor behavior, increased invasiveness, and poorer prognosis across various cancer types. CHK2 plays a crucial role in maintaining genomic stability, and its dysfunction can lead to increased susceptibility to DNA damage and tumorigenesis.
Scientific Papers found: Click to Expand⟱
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, NA, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
1520- Ba,    Baicalein Induces G2/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, TOV-21G
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, Chk2↑, Dose∅, p‑γH2AX↑, CDC25↓, CHK1↓, cycD1/CCND1↓, eff↓, 12LOX↓,
1328- EMD,    Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways
- in-vitro, Tong, SCC4
TumCCA↑, P21↑, Chk2↑, CycB/CCNB1↓, cDC2↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Casp3↑, ROS↑, MMP↓, Bax:Bcl2↑, ER Stress↑,
1655- FA,    Ferulic acid inhibiting colon cancer cells at different Duke’s stages
- in-vitro, Colon, SW480 - in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCCA↑, Apoptosis↑, ATM↑, Chk2↑, ATR↑, CHK1↑, CK2↓, cycA1/CCNA1↑, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2↓, IAP2↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
488- MF,    Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells
- in-vitro, NA, HeLa - in-vitro, NA, IMR90
DNAdam↑, p‑γH2AX↑, Chk2↑, p38↑, Apoptosis↑,
487- MF,    Extremely Low-Frequency Electromagnetic Fields Cause G1 Phase Arrest through the Activation of the ATM-Chk2-p21 Pathway
- in-vitro, NMSC, HaCaT
ATM↑, Chk2↑, P21↑, TumCCA↑,
4944- PEITC,    Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations
- in-vitro, Oral, NA
TumCG↓, TumCCA↑, Apoptosis↑, ROS↑, NO↑, GSH↓, MMP↓, DNAdam↑, ATM↑, Chk2↑, P53↑, eff↓,
913- QC,    Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-435
TumCP↓, TumCCA↑, DNAdam↑, Chk2↑, CycB/CCNB1↓, CDK1↓, tumCV↓, p‑RB1↓, P21↑,
1434- SFN,  GEM,    Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
- in-vitro, CCA, HuCCT1 - in-vitro, CCA, HuH28 - in-vivo, NA, NA
HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ATF3↑, 1,   Catalase↑, 1,   Ferroptosis↑, 1,   GPx↑, 2,   GSH↓, 1,   GSH↑, 1,   GSR↑, 2,   GSTA1↑, 1,   HO-1↑, 1,   lipid-P↑, 1,   NQO1?, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 1,   ROS↑, 6,   mt-ROS↑, 1,   SIRT3↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC2↓, 2,   CDC25↓, 3,   mitResp↓, 2,   MMP↓, 5,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   cMyc↓, 2,   p‑CREB↓, 1,   Glycolysis↓, 1,   LDHA↓, 1,   NADPH↑, 1,   PCK1↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 3,   Apoptosis↑, 9,   BAX↓, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp↑, 2,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp9↑, 1,   cl‑Casp9↑, 1,   Chk2↓, 3,   Chk2↑, 8,   p‑Chk2↓, 1,   p‑Chk2↑, 2,   CK2↓, 1,   Cyt‑c↑, 3,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   HEY1↓, 1,   IAP2↓, 1,   iNOS↓, 1,   MAPK↓, 2,   MAPK↑, 1,   Mcl-1↓, 1,   oncosis↑, 1,   p27↑, 1,   p38↑, 2,   p‑p38↓, 2,   p‑RSK↓, 1,   survivin↓, 2,   TumCD↑, 1,   TUNEL↑, 1,  

Transcription & Epigenetics ⓘ

H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 4,   p‑ATM↑, 1,   ATR↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   CHK1↓, 4,   CHK1↑, 2,   p‑CHK1↑, 1,   DNAdam↓, 1,   DNAdam↑, 6,   HR↓, 1,   p16↑, 1,   P53↓, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 2,   RAD51↓, 1,   γH2AX↓, 1,   γH2AX↑, 1,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 2,   CDK4↓, 4,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 3,   cycE1↓, 1,   E2Fs↑, 1,   P21↑, 8,   p‑RB1↓, 2,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State ⓘ

cDC2↓, 1,   cMET↓, 1,   CSCs↓, 2,   EMT?, 1,   EMT↓, 1,   ERK↓, 3,   p‑ERK↓, 1,   FOXO3↑, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   mTOR↓, 2,   mTORC1↓, 1,   mTORC2↓, 1,   NOTCH↓, 1,   PI3K↓, 1,   RAS↓, 1,   STAT3↓, 4,   p‑STAT5↓, 1,   TumCG↓, 3,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 1,   CDK4/6↓, 1,   E-cadherin↑, 2,   ER-α36↓, 1,   ITGB1↑, 1,   Ki-67↓, 2,   MMP13↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 2,   MMPs↓, 2,   N-cadherin↓, 2,   NCAM↑, 1,   Rho↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 5,   TumMeta↓, 1,   TumMeta↑, 1,   uPA↓, 2,   Vim↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 1,   eNOS↓, 1,   Hif1a↓, 3,   KDR/FLK-1↓, 1,   NO↓, 1,   NO↑, 1,   PDGFR-BB↓, 1,   VEGF↓, 5,   VEGFR2↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↓, 1,   IL1↑, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 2,   JAK1↓, 2,   MIP2↓, 1,   NF-kB↓, 4,   p65↓, 1,   PGE2↓, 2,   SOCS1↑, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 1,   ChemoSen↑, 2,   Dose↝, 2,   Dose∅, 1,   eff↓, 2,   eff↑, 3,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

BRCA1↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   IL6↓, 2,   Ki-67↓, 2,  

Functional Outcomes ⓘ

chemoP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   RenoP↑, 2,  
Total Targets: 210

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Prx↑, 1,   ROS↓, 1,   SOD2↑, 1,  

Cell Death ⓘ

Casp3?, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 7

Scientific Paper Hit Count for: Chk2, Checkpoint Kinase 2
2 Artemisinin
2 Magnetic Fields
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Emodin
1 Ferulic acid
1 Fisetin
1 Lycopene
1 Phenethyl isothiocyanate
1 Quercetin
1 Sulforaphane (mainly Broccoli)
1 Gemcitabine (Gemzar)
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:754  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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