Database Query Results : , , RPM

RPM, radical pair mechanism: Click to Expand ⟱
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Type:
The radical pair mechanism is a process that involves the interaction of two radicals (highly reactive molecules with unpaired electrons) and has been found to be sensitive to magnetic fields. In the presence of a magnetic field, the radical pair mechanism can be influenced, leading to changes in the reaction rates and yields.
The magnetic field effect on radical pair reactions can be explained by the following mechanisms:
Spin-correlated radical pairs: In the presence of a magnetic field, the spin-correlated radical pairs can be formed, which can lead to changes in the reaction rates and yields.

Spin relaxation: The magnetic field can influence the spin relaxation of the radicals, leading to changes in the reaction rates and yields.

Magnetic field-induced intersystem crossing: The magnetic field can induce intersystem crossing between the singlet and triplet states, leading to changes in the reaction rates and yields.

-Radical pairs live 1-10ms. PEMFs can influence spin states of short-lived radical pairs formed in biochemical reactions. (PEMF may need to be in that range).
If PEMF modifies spin-states, it could slightly bias:
-ETC(Electron Transport Chain) forward throughput
-ROS vs ATP balance
-Mitochondrial signaling pathways (e.g., NRF2, AMPK, HIF-1α)
This is analogous to how very weak magnetic fields alter bird magnetoreception.



Scientific Papers found: Click to Expand⟱
2245- MF,    Quantum based effects of therapeutic nuclear magnetic resonance persistently reduce glycolysis
- in-vitro, Nor, NIH-3T3
Warburg↓, Hif1a↓, *Hif1a∅, Glycolysis↓, *lactateProd↓, *ADP:ATP↓, Pyruv↓, ADP:ATP↓, *PPP↓, *mt-ROS↑, *ROS↓, RPM↑, *ECAR↓,
2244- MF,    Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer
- Review, Var, NA
RPM↑, Glycolysis∅, ROS↑, ChemoSen↑, RadioS↑, selectivity↑,
590- MF,  VitC,    Sub-millitesla magnetic field effects on the recombination reaction of flavin and ascorbic acid radicals
- in-vitro, NA, NA
RPM↑,
592- MF,  VitC,    Alternative radical pairs for cryptochrome-based magnetoreception
RPM↑,
594- MF,  VitC,    Static Magnetic Field Effect on the Fremy's Salt-Ascorbic Acid Chemical Reaction Studied by Continuous-Wave Electron Paramagnetic Resonance
- Analysis, NA, NA
RPM↑,
521- MF,    Magnetic field effects in biology from the perspective of the radical pair mechanism
- Analysis, NA, NA
*RPM↑, *ROS↝,
188- MFrot,  MF,    Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells
- in-vitro, GBM, GBM115 - in-vitro, GBM, DIPG
ROS↑, SDH↓, eff↓, RPM↑, eff↓, eff↑, eff↝, eff↝, Casp3↑, eff↝, SOD↓, ETC↓,
593- VitC,  MF,    Protective Effect of Ascorbic Acid on Molecular Behavior Changes of Hemoglobin Induced by Magnetic Field Induced by Magnetic Field
RPM↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,   RPM↓, 1,   RPM↑, 6,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↓, 1,   ETC↓, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   Glycolysis∅, 1,   Pyruv↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Casp3↑, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 2,   eff↑, 1,   eff↝, 3,   RadioS↑, 1,   selectivity↑, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,   ROS↝, 1,   mt-ROS↑, 1,   RPM↑, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   lactateProd↓, 1,   PPP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a∅, 1,  
Total Targets: 9

Scientific Paper Hit Count for: RPM, radical pair mechanism
8 Magnetic Fields
4 Vitamin C (Ascorbic Acid)
1 Magnetic Field Rotating
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:762  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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