Database Query Results : , , BMP2

BMP2, Bone Morphogenetic Protein 2: Click to Expand ⟱
Source:
Type:
BMP2 (Bone Morphogenetic Protein 2) is a member of the TGF-β (Transforming Growth Factor-beta) superfamily, which plays a crucial role in regulating cell growth, differentiation, and apoptosis.
BMP2 is overexpressed in: Osteosarcoma, breast, lung, prostate cancers.
Scientific Papers found: Click to Expand⟱
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,
530- MF,    Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2
- in-vivo, Nor, NA
*miR-34b-5p↓, *ALP↑, *RUNX2↑, *BMP2↑, *OCN↑, *OPN↑, *β-catenin/ZEB1↑, *STAC2↑, *Diff↑, *BMD↑,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
4931- PEITC,    Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Risk↓, miR-194↑, TumCI↓, MMP2↓, MMP9↓, BMP2↓, *chemoPv↑,
880- RES,    Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol
- in-vitro, BC, MDA-MB-231
other↓, TumW↓, FOXO↑, BMP2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MKK4↓, 1,   Raf↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Bax:Bcl2↑, 1,   BMP2↓, 2,   BMP2↑, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   p‑ERK↓, 1,   FOXO↑, 1,   miR-194↑, 1,  

Migration ⓘ

F-actin↓, 1,   MMP2↓, 2,   MMP9↓, 2,   TumCI↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

Risk↓, 1,   TumW↓, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Cell Death ⓘ

Akt↑, 2,   BMP2↑, 2,   MAPK↑, 1,  

Kinase & Signal Transduction ⓘ

OCN↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 2,   ERK↑, 1,   mTOR↑, 1,   PI3K↑, 1,   RUNX2↑, 1,  

Migration ⓘ

OPN↑, 1,   PKA↑, 1,   PKCδ↓, 1,   STAC2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

miR-34b-5p↓, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

ALP↑, 1,   BMD↑, 1,  
Total Targets: 21

Scientific Paper Hit Count for: BMP2, Bone Morphogenetic Protein 2
2 Magnetic Fields
1 Myricetin
1 Phenethyl isothiocyanate
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:777  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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