Database Query Results : , , CXCR4

CXCR4, Chemokine Receptor Type 4: Click to Expand ⟱
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Chemokine Receptor Type 4 (CXCR4) is a G protein-coupled receptor that plays a significant role in various physiological processes, including immune responses, hematopoiesis, and organ development. It is also implicated in cancer biology, where it has been associated with tumor progression, metastasis, and the tumor microenvironment.
CXCR4 is often overexpressed in various types of cancers, including breast, lung, prostate, and pancreatic cancers. Its activation can promote tumor cell proliferation and survival.
-CXCR4 proteins associated with metastasis


Scientific Papers found: Click to Expand⟱
3169- Ash,    Withaferin A blocks formation of IFN-γ-induced metastatic cancer stem cells through inhibition of the CXCR4/CXCL12 pathway in the UP-LN1 carcinoma cell model
- in-vitro, GC, NA
CXCR4↓, CXCL12↓,
3168- Ash,    Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model
- in-vitro, Var, NA
CXCR4↓, STAT3↓, CSCs↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
1169- Bos,    Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
- in-vivo, CRC, NA
TumCG↓, TumVol↓, Weight∅, ascitic↓, TumMeta↓, Ki-67↓, CD31↓, NF-kB↓, COX2↓, Bcl-2↓, Bcl-xL↓, IAP1↓, survivin↓, cycD1/CCND1↓, ICAM-1↓, MMP9↓, CXCR4↓, VEGF↓,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, NA, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
1422- Bos,    Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family
- in-vitro, CRC, NA - in-vivo, NA, NA
5LO↓, TumCG↓, Let-7↑, miR-200b↑, NF-kB↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, VEGF↓, Bcl-xL↓, survivin↓, IAP1↓, XIAP↓, TumCG↓, CDK6↓, Vim↓, E-cadherin↑,
1423- Bos,    Acetyl-11-keto-β-Boswellic Acid Suppresses Invasion of Pancreatic Cancer Cells Through The Downregulation of CXCR4 Chemokine Receptor Expression
- in-vitro, Melanoma, U266 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3 - in-vitro, PC, PANC1
CXCR4↓, TumCI↓, HER2/EBBR2↓, NF-kB↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
140- CUR,    Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
- in-vitro, Pca, PC3
CAFs/TAFs↓, EMT↓, ROS↓, CXCR4↓, IL6↓, MAOA↓, mTOR↓, HIF-1↓,
1323- EMD,    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
- Review, Cerv, NA
TumCCA↑, DNAdam↑, mTOR↓, Casp3↑, Casp8↑, Casp9↑, TGF-β↑, SMAD3↓, p‑SMAD4↓, ROS↑, MMP↓, CXCR4↓, HER2/EBBR2↓, ER Stress↓, TumAuto↑, NOTCH1↓,
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
3373- QC,    The Effect of Quercetin in the Yishen Tongluo Jiedu Recipe on the Development of Prostate Cancer through the Akt1-related CXCL12/ CXCR4 Pathway
- in-vitro, Pca, DU145
TumCP↓, Casp3↑, Bcl-2↓, Apoptosis↑, TumCI↓, TumCMig↓, CXCL12↓, CXCR4↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↝, Fas↝, Hsc70↝, Hif1a↝, Mcl-1↝, HSP90↝, FLT4↝, EphB4↝, DNA-PK↝, PARP1↝, ATM↝, XIAP↝, PLC↝, GnT-V↝, heparanase↝, NM23↝, CSR1↝, SPP1↝, DNMT1↝, HDAC4↝, CXCR4↝, β-catenin/ZEB1↝, FBXW7↝, AMACR↝, cycD1/CCND1↝, IGF-1R↝, IMPDH1↝, IMPDH2↝, HEC1↝, NHE1↝, NOS2↝,
59- QC,    Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)
- in-vitro, BC, MDA-MB-231
ALDH1A1↓, CXCR4↓, MUC1↓, EpCAM↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
3198- SFN,    Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
- in-vitro, Pca, NA
Nanog↓, SOX2↓, E-cadherin↓, Snail↓, VEGFR2↓, Diff↓, TumCMig↓, EMT↓, CXCR4↓, NOTCH1↓, ALDH1A1↓, CSCs↓, eff↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 30

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

CYP1A1↓, 1,   GSH↓, 2,   GSH↑, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P?, 1,   MPO↓, 1,   NRF2↓, 1,   NRF2↑, 2,   Prx4↑, 1,   ROS↓, 3,   ROS↑, 11,   ROS⇅, 1,   SOD↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   CDC2↓, 2,   CDC25↓, 1,   MEK↓, 1,   MMP↓, 5,   Raf↓, 1,   XIAP↓, 3,   XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↝, 1,   AMPK↑, 4,   ATG7↑, 1,   cMyc↓, 9,   p‑cMyc↑, 1,   Glycolysis↓, 3,   HK2↓, 2,   NADPH↑, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑S6K↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   SIRT2↓, 1,  

Cell Death ⓘ

Akt↓, 10,   p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 6,   aSmase↝, 1,   BAX↑, 7,   Bax:Bcl2↑, 1,   Bcl-2↓, 10,   Bcl-xL↓, 5,   BID↓, 1,   Casp↑, 3,   Casp3↓, 1,   Casp3↑, 12,   cl‑Casp3↑, 1,   Casp7↑, 3,   Casp8↑, 4,   cl‑Casp8↑, 1,   Casp9↑, 9,   cl‑Casp9↑, 2,   cFLIP↓, 2,   CSR1↝, 1,   Cyt‑c↑, 6,   Diablo↑, 2,   Diablo↝, 1,   DR4↑, 1,   DR5↑, 3,   Fas↑, 2,   Fas↝, 1,   hTERT/TERT↓, 1,   IAP1↓, 2,   iNOS↓, 4,   JNK↑, 3,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p‑MAPK↑, 1,   Mcl-1↓, 3,   Mcl-1↝, 1,   MDM2↓, 1,   Myc↓, 1,   NICD↓, 1,   p27↑, 3,   p38↑, 2,   p‑p38↓, 1,   p‑p38↑, 2,   PUMA↑, 1,   survivin↓, 10,   Telomerase↓, 2,   TRAIL↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 3,   Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   p‑pRB↓, 1,   SPP1↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   Hsc70↝, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   HSP90↝, 1,   p‑PERK↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B↓, 1,   LC3B-II↑, 1,   LC3II↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

ATM↝, 1,   CYP1B1↑, 1,   DNA-PK↝, 1,   DNAdam↑, 6,   DNMT1↓, 2,   DNMT1↝, 1,   DNMTs↓, 1,   p16↑, 1,   P53↑, 8,   cl‑PARP↑, 7,   PARP1↑, 1,   PARP1↝, 1,   PCNA↓, 3,   TP53↑, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 6,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 14,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 4,   E2Fs↓, 1,   P21↑, 7,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   ALDH1A1↓, 2,   CD133↓, 2,   CD44↓, 2,   cMET↓, 1,   p‑cMET↑, 1,   CSCs↓, 6,   Diff↓, 2,   EMT↓, 8,   EpCAM↓, 1,   ERK↓, 7,   ERK↑, 1,   p‑ERK↓, 4,   FBXW7↝, 1,   FOXO↑, 1,   Gli1↓, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 3,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↝, 1,   IGF-1↓, 1,   IGF-1R↝, 1,   Let-7↑, 3,   mTOR↓, 8,   p‑mTOR↓, 2,   p‑mTORC1↓, 1,   n-MYC↓, 1,   Nanog↓, 2,   Nestin↓, 3,   NOTCH↓, 2,   NOTCH1↓, 4,   P70S6K↓, 1,   PI3K↓, 8,   PTEN↑, 5,   RAS↓, 2,   RAS↑, 1,   Shh↓, 2,   SOX2↓, 2,   STAT1↓, 1,   STAT3↓, 9,   p‑STAT3↓, 3,   STAT6↓, 1,   TAZ↓, 1,   TCF↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TOP2↑, 1,   TumCG↓, 5,   Wnt↓, 6,  

Migration ⓘ

5LO↓, 3,   AEG1↓, 1,   AntiAg↓, 1,   AP-1↓, 2,   Ca+2↑, 1,   CAFs/TAFs↓, 1,   CD31↓, 1,   CLDN2↓, 1,   CXCL12↓, 3,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 8,   EphB4↝, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   Ki-67↓, 3,   MALAT1↓, 1,   MET↓, 1,   miR-200b↑, 2,   MMP1↓, 2,   MMP2↓, 10,   MMP7↓, 3,   MMP9↓, 16,   MMPs↓, 2,   MUC1↓, 1,   N-cadherin↓, 6,   NM23↝, 1,   PDGF↓, 1,   PKCδ↓, 1,   Slug↓, 2,   SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail↓, 4,   SOX4↑, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↑, 2,   TIMP2↑, 2,   TSP-1↑, 1,   TumCI↓, 6,   TumCMig↓, 7,   TumCP↓, 6,   TumMeta↓, 7,   Twist↓, 6,   uPA↓, 2,   uPAR↓, 1,   VCAM-1↓, 1,   Vim↓, 7,   Zeb1↓, 4,   β-catenin/ZEB1↓, 8,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 7,   ATF4↝, 1,   EGFR↓, 4,   FLT4↝, 1,   HIF-1↓, 2,   Hif1a↓, 7,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 18,   VEGFR2↓, 7,  

Barriers & Transport ⓘ

NHE1↝, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CCR7↓, 1,   COX2↓, 15,   CXCL1↓, 1,   CXCR4↓, 29,   CXCR4↝, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IKKα↓, 2,   IL1↓, 3,   IL10↓, 2,   IL12↓, 2,   IL1α↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 1,   IL4↓, 1,   IL6↓, 10,   Inflam↓, 6,   JAK2↓, 4,   MCP1↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 16,   p‑NF-kB↑, 1,   p50↓, 1,   p65↓, 1,   PGE2↓, 5,   PSA↓, 1,   TNF-α↓, 4,  

Cellular Microenvironment ⓘ

PLC↝, 1,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,   MAOA↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   CDK6↓, 5,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 9,   ChemoSen⇅, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 3,   eff↑, 27,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 3,   MRP1↓, 1,   P450↓, 1,   RadioS↑, 5,   selectivity↑, 4,   TET2↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 3,   ascitic↓, 2,   BMPs↑, 1,   EGFR↓, 4,   EZH2↓, 1,   HEC1↝, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 1,   IL6↓, 10,   Ki-67↓, 3,   Myc↓, 1,   NOS2↝, 1,   PSA↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 4,   hepatoP↑, 3,   IMPDH1↝, 1,   IMPDH2↝, 1,   radioP↑, 3,   toxicity↓, 1,   TumVol↓, 2,   Weight∅, 1,  
Total Targets: 344

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   Catalase↑, 4,   GPx↑, 3,   GSH↑, 4,   GSTs↑, 2,   HO-1↑, 2,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 3,   ROS↓, 6,   SOD↑, 4,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   LDH↑, 1,   NAD↑, 1,   NADPH↓, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Casp3↓, 1,   MAPK↑, 1,  

Migration ⓘ

5LO↓, 1,   Ca+2↝, 1,   p‑Rac1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   NO↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 2,   IKKα↑, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 5,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 4,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 1,   Dose↝, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   CRP↓, 2,   IL6↓, 3,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   cognitive↓, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 4,   RenoP↑, 1,   toxicity↓, 2,  
Total Targets: 55

Scientific Paper Hit Count for: CXCR4, Chemokine Receptor Type 4
7 Boswellia (frankincense)
4 Quercetin
3 Silymarin (Milk Thistle) silibinin
3 Thymoquinone
2 Ashwagandha(Withaferin A)
2 Resveratrol
2 Sulforaphane (mainly Broccoli)
1 Berberine
1 Curcumin
1 Emodin
1 Garcinol
1 Honokiol
1 Luteolin
1 Piperlongumine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:79  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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