Database Query Results : , , oncosis

oncosis, Oncosis: Click to Expand ⟱
Source:
Type: type of cell death
Oncosis is a type of cell death that is characterized by cell swelling, organelle swelling, and eventual rupture of the cell membrane. It is often referred to as "accidental cell death" or "necrotic cell death" because it is not a programmed or regulated process, unlike apoptosis (programmed cell death).
Scientific Papers found: Click to Expand⟱
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis ⓘ

AMP↓, 1,   cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   p‑Chk2↑, 1,   Ferroptosis↑, 1,   Myc↓, 1,   oncosis↑, 2,   p27↑, 1,   survivin↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   p‑CHK1↑, 1,   DNAdam↑, 1,   HR↓, 1,   p16↑, 1,   RAD51↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   cycE1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

cMET↓, 1,   CREBBP↓, 1,   ERK↓, 1,   mTOR↓, 2,   PI3K↓, 1,   Wnt/(β-catenin)↓, 1,   Wnt/(β-catenin)↑, 1,  

Migration ⓘ

CDK4/6↓, 1,   E-cadherin↑, 1,   ITGB1↑, 1,   LysoPr↑, 1,   MMP2↓, 1,   NCAM↑, 1,   TGF-β↓, 1,   TIMP2↑, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↓, 1,   KDR/FLK-1↓, 1,   NO↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1↓, 1,   IL6↓, 1,   MIP2↓, 1,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   IL6↓, 1,   Myc↓, 1,  
Total Targets: 52

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: oncosis, Oncosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:791  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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