Database Query Results : , , G9a

G9a, G9a: Click to Expand ⟱
Source:
Type: enzyme
G9a is a histone methyltransferase enzyme that plays a crucial role in various cellular processes, including gene expression, DNA repair, and cell cycle regulation.
G9a has been found to be overexpressed in various types of cancer, including breast, lung, colon, and prostate cancer. This overexpression is often associated with poor prognosis and reduced survival rates.
Scientific Papers found: Click to Expand⟱
672- EGCG,    Molecular Targets of Epigallocatechin—Gallate (EGCG): A Special Focus on Signal Transduction and Cancer
- Review, NA, NA
DNMT1↓, HDAC↓, G9a↓, PRC2↓, DNMT3A↓, 67LR↓, Apoptosis↑, TumCCA↑,
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, HDAC↓, HMTs↓, DNMT3A↓, EZH2↓, HDAC1↓, HDAC2↓, HDAC6↓, HDAC11↓, G9a↓, TIMP3↑, PTEN↑, SOCS1↑,
3426- TQ,    Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms
- in-vitro, BC, MDA-MB-468 - in-vitro, AML, JK
UHRF1↓, DNMT1↓, DNMT3A↓, DNMTs↓, HDAC1↓, HDAC4↓, HDAC↓, DLC1↑, PPARγ↑, FOXO↑, TET2↑, CYP1B1↑, G9a↓,
3424- TQ,    Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex
- Review, Var, NA
DNMT1↓, HDAC1↓, TumCCA↑, ROS↑, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, BioAv↓, BioAv↓, HDAC1↓, HDAC4↓, UHRF1↓, selectivity↑, G9a↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

PPARγ↑, 1,  

Cell Death ⓘ

Apoptosis↑, 2,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   PRC2↓, 1,  

DNA Damage & Repair ⓘ

CYP1B1↑, 1,   DNMT1↓, 3,   DNMT3A↓, 3,   DNMTs↓, 2,   G9a↓, 4,   UHRF1↓, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1,   HDAC↓, 3,   HDAC1↓, 4,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC4↓, 2,   HDAC6↓, 1,   HMTs↓, 1,   PTEN↑, 1,  

Migration ⓘ

67LR↓, 1,   DLC1↑, 1,   TIMP3↑, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

SOCS1↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   selectivity↑, 2,   TET2↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,  
Total Targets: 31

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: G9a, G9a
2 Thymoquinone
1 EGCG (Epigallocatechin Gallate)
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:832  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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