Database Query Results : , , SUZ12

SUZ12, Suppressor of zeste 12: Click to Expand ⟱
Source:
Type:
SUZ12 (Suppressor of zeste 12) is a protein that plays a crucial role in the regulation of gene expression through histone modification. It is a key component of the Polycomb repressive complex 2 (PRC2), which is involved in the silencing of genes through histone methylation.
Overexpression of SUZ12 has been observed in many types of cancer, and it is often associated with poor prognosis and reduced survival rates.
Direction of Regulation in Cancer
Context-dependent, with two dominant patterns:

A. Functionally UPREGULATED (most common)
-PRC2 activity is increased (often via EZH2 overactivity, but SUZ12 is required)
-Results in excessive H3K27me3
-Locks down tumor suppressor and differentiation genes

B. Loss-of-function in select cancers
-SUZ12 deletions or inactivating alterations occur in specific tumor types
-Leads to epigenetic instability and aberrant gene activation

Thus, SUZ12 can behave as an oncogenic enabler or a tumor suppressor, depending on context.

SUZ12 is a contextual epigenetic biomarker that defines whether PRC2 repression is intact. Its loss acts as a negative predictive marker for PRC2/EZH2 dependency, while its presence enables EZH2-driven biology. SUZ12 rarely changes management alone, but it is essential for correct interpretation of EZH2 and Polycomb-targeted strategies.


Scientific Papers found: Click to Expand⟱
679- EGCG,  5-FU,    Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer
- in-vitro, CRC, NA
NOTCH1↓, BMI1↓, SUZ12↓, EZH2↓, miR-34a↑, miR-200c↑, miR-145↑, CSCs↓,
4928- PEITC,    Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
- vitro+vivo, Colon, SW-620
Risk↓, HDAC↓, TumW↓, TumCG↓, AP-1↓, cAMP↓, NF-kB↓, BMI1↓, SUZ12↓, EZH2↓, selectivity↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

cAMP↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 2,   miR-145↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

BMI1↓, 2,   CSCs↓, 1,   HDAC↓, 1,   miR-34a↑, 1,   NOTCH1↓, 1,   SUZ12↓, 2,   TumCG↓, 1,  

Migration ⓘ

AP-1↓, 1,   miR-200c↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 2,   SUZ12↓, 2,  

Functional Outcomes ⓘ

Risk↓, 1,   TumW↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SUZ12, Suppressor of zeste 12
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:838  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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