Database Query Results : , , E6

E6, E6: Click to Expand ⟱
Source:
Type: oncoprotein
E6 is a protein encoded by the human papillomavirus (HPV) genome, specifically by the high-risk HPV types 16 and 18. E6 is a key oncoprotein that plays a crucial role in the development and progression of cervical cancer, as well as other HPV-related cancers.
E6 is often used as a biomarker for HPV-related cancers, and its detection can help diagnose and monitor the progression of these cancers.

E6 is a potent viral oncoprotein that drives cancer by eliminating p53 and enabling immortalization
Scientific Papers found: Click to Expand⟱
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB/CCNB1↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, NA, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
884- RES,  PTS,    Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells
- in-vitro, Cerv, HeLa
TumCD↑, TumCCA↑, E6↓, Casp3↑, P53↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   ATF3↑, 1,   Ferroptosis↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSR↑, 1,   HO-1↑, 2,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 2,   NQO1↑, 1,   NRF2↑, 1,   ROS↑, 4,   ROS⇅, 1,   SIRT3↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC2↓, 1,   CDC2↑, 1,   mitResp↓, 1,   MMP↓, 2,   MPT↑, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   FASN↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   NADPH↑, 1,   PDK1↓, 1,   PI3K/Akt↓, 1,   PPARγ↑, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 4,   p‑Akt↓, 1,   Apoptosis↑, 1,   Bak↑, 1,   BAX↑, 3,   Bcl-2↓, 2,   Bcl-2↑, 1,   BIM↑, 1,   Casp↑, 2,   Casp3↑, 4,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Chk2↓, 1,   Cyt‑c↑, 2,   DR5↑, 2,   Ferroptosis↑, 1,   HEY1↓, 1,   iNOS↓, 1,   MAPK↑, 2,   Mcl-1↓, 1,   p27↑, 1,   p38↓, 1,   p38↑, 2,   TumCD↑, 2,  

Kinase & Signal Transduction ⓘ

RET↓, 1,  

Transcription & Epigenetics ⓘ

H3↑, 1,   pRB↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   eIF2α↓, 1,   ER Stress↑, 1,   HSP90↓, 4,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNAdam↑, 1,   P53↑, 6,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 2,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycE/CCNE↓, 1,   P21↑, 3,   p‑RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD44↓, 1,   cMET↓, 1,   CSCs↓, 2,   EMT↓, 2,   EMT↑, 1,   ERK↓, 2,   p‑ERK↓, 1,   FOXO3↑, 1,   IGF-1↓, 1,   mTOR↓, 2,   mTOR⇅, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 2,   PI3K↓, 1,   PTEN↑, 1,   SOX2↓, 1,   STAT3↓, 3,   Wnt↓, 2,  

Migration ⓘ

AP-1↓, 2,   ER-α36↓, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TSC1↑, 1,   TumCP↓, 1,   Twist↓, 1,   uPA↓, 2,   Vim↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ATF4↑, 1,   EGFR↓, 1,   HIF-1↓, 1,   Hif1a↓, 1,   NO↓, 1,   PDGFR-BB↓, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 4,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   Dose↝, 1,   Dose∅, 1,   eff↑, 5,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,   E6↓, 8,   E7↓, 7,   EGFR↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

RenoP↑, 1,  
Total Targets: 142

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   NRF2↑, 1,   Prx↑, 1,   SOD2↑, 1,  

Cell Death ⓘ

Casp3?, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   Half-Life∅, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,   toxicity↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: E6, E6
4 Ashwagandha(Withaferin A)
1 alpha Linolenic acid
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Resveratrol
1 Pterostilbene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:841  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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