Database Query Results : , , p50

p50, p50: Click to Expand ⟱
Source:
Type:
p50 is a protein that is part of the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) transcription factor complex. NF-κB is a key regulator of immune responses, inflammation, and cell survival, and it plays a critical role in the development and progression of various types of cancer.
p50 is one of the two subunits of the NF-κB complex, the other being p65. The p50/p65 heterodimer is the most common form of NF-κB, and it is activated by a wide range of stimuli, including cytokines, growth factors, and stress.
In cancer, p50 is often overexpressed or constitutively activated, leading to the promotion of cell proliferation, survival, and metastasis.
Scientific Papers found: Click to Expand⟱
1560- Api,    Apigenin as an anticancer agent
- Review, NA, NA
Apoptosis↑, Casp3∅, Casp8∅, TNF-α∅, Cyt‑c↑, MMP2↓, MMP9↓, Snail↓, Slug↓, NF-kB↓, p50↓, PI3K↓, Akt↓, p‑Akt↓,
1334- AS,    Astragalus membranaceus: A Review of Its Antitumor Effects on Non-Small Cell Lung Cancer
- Review, NA, NA
TumCP↓, Apoptosis↑, NF-kB↓, p50↓, cycD1/CCND1↓, Bcl-xL↓, ChemoSen↑, angioG↓, ChemoSen↑,
2980- CUR,    Inhibition of NF B and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation
- in-vivo, PC, NA
TumCG↓, p50↓, p65↓, NF-kB↓, Sp1/3/4↓, MMP↓, ROS↑,
686- EGCG,    Prevention effect of EGCG in rat's lung cancer induced by benzopyrene
- in-vivo, Lung, NA
NF-kB↓, p50↓, Ki-67↓,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
1746- RosA,    Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells
- in-vitro, AML, U937
TNF-α↓, ROS↓, Casp↑, NF-kB↓, IκB↓, p50↓, p65↓, IAP1↓, IAP2↓, XIAP↓, Apoptosis↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
2211- SK,    Shikonin mitigates ovariectomy-induced bone loss and RANKL-induced osteoclastogenesis via TRAF6-mediated signaling pathways
- in-vivo, ostP, NA
*BMD↑, *p‑NF-kB↓, *p‑p50↓, *p‑p65↓, *p‑ERK↓, *p‑cJun↓, *p‑p38↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 1,   MPO↓, 1,   ROS↓, 3,   ROS↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,   cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 3,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 2,   Casp3∅, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp8∅, 1,   Casp9↓, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   Diablo↑, 1,   Fas↑, 1,   IAP1↓, 1,   IAP2↓, 1,   p38↑, 1,   PUMA↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,  

DNA Damage & Repair ⓘ

DNMTs↓, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CSCs↓, 1,   EMT↓, 1,   ERK↓, 1,   IGF-1↓, 1,   mTOR↓, 1,   PI3K↓, 2,   TumCG↓, 1,  

Migration ⓘ

E-cadherin↑, 2,   Ki-67↓, 1,   MMP2↓, 3,   MMP9↓, 3,   N-cadherin↓, 2,   Slug↓, 1,   Snail↓, 2,   TumCP↓, 1,   Twist↓, 1,   VCAM-1↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CXCR4↓, 1,   IKKα↓, 1,   IL12↓, 1,   IL1β↓, 1,   IL6↓, 1,   IκB↓, 1,   p‑IκB↓, 1,   NF-kB↓, 7,   p50↓, 7,   p65↓, 3,   TNF-α↓, 2,   TNF-α∅, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   Dose↝, 2,   eff↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

ChemoSideEff↓, 1,   neuroP↑, 1,  
Total Targets: 91

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

p‑cJun↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑NF-kB↓, 1,   p‑p50↓, 1,   p‑p65↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: p50, p50
2 Rosmarinic acid
1 Apigenin (mainly Parsley)
1 Astragalus
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Sulforaphane (mainly Broccoli)
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:842  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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