Database Query Results : , , JWA

JWA, JWA protein or JWA gene: Click to Expand ⟱
Source:
Type:
JWA (also known as JWA protein or JWA gene) is a protein that has been implicated in various cellular processes, including cell cycle regulation, apoptosis, and DNA repair.
JWA is frequently downregulated or mutated in various types of cancer, including breast, lung, colon, and ovarian cancer.
JWA, a microtubular binding tumour suppressor protein that downregulates topoisomerase II-alpha, resulting in G2/M arrest in NSCLC cells.
Scientific Papers found: Click to Expand⟱
692- EGCG,    EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement
- Review, NA, NA
ROS↑, Apoptosis↑, DNAdam↑, CTR1↑, JWA↑, β-catenin/ZEB1↓, P53↑, Vim↓, VEGF↓, p‑Akt↓, Hif1a↓, COX2↓, ERK↓, NF-kB↓, Akt↓, Bcl-xL↓, miR-210↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   Bcl-xL↓, 1,   JWA↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Migration ⓘ

Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   miR-210↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

CTR1↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: JWA, JWA protein or JWA gene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:845  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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