Database Query Results : , , LAMP2

LAMP2, Lysosome-Associated Membrane Protein 2: Click to Expand ⟱
Source:
Type:
LAMP-2 (Lysosome-Associated Membrane Protein 2) is a protein that plays a crucial role in the function and maintenance of lysosomes, which are organelles responsible for cellular digestion and recycling.
LAMP-2 is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. Cancer cells often exploit autophagy to promote their survival and growth. LAMP-2 is overexpressed in various types of cancer, including breast, lung, colon, and prostate cancer.
High LAMP-2 expression is correlated with poor prognosis, including reduced overall survival and increased risk of recurrence.
Scientific Papers found: Click to Expand⟱
709- Bor,    Cellular changes in boric acid-treated DU-145 prostate cancer cells
- in-vitro, Pca, DU145
Cyc↓, MAPK↓, TumCMig↓, LAMP2↓, p‑ERK⇅, TumCM/A↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
2406- SFN,    Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach
- Review, Pca, NA
HK2↓, PKM2↓, LDHA↓, Glycolysis↓, LAMP2↑, Hif1a↓, DNAdam↓, DNArepair↓, Dose↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↓, 1,   OXPHOS↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   Insulin↓, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 2,   HK2↓, 1,   LDHA↓, 1,   PKM2↓, 1,   SIRT1↑, 1,   TumCM/A↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

MAPK↓, 2,   TumCD↑, 1,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   Beclin-1↑, 1,   LAMP2↓, 1,   LAMP2↑, 2,   p62↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 1,   DNArepair↓, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

Cyc↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK⇅, 1,   HDAC↓, 1,   IGF-1↓, 1,   STAT5↓, 1,  

Migration ⓘ

Treg lymp↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

M2 MC↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,   GutMicro↑, 2,  

Functional Outcomes ⓘ

ChemoSideEff↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 39

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LAMP2, Lysosome-Associated Membrane Protein 2
1 Boron
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:855  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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