Database Query Results : , , COL1A1

COL1A1, Collagen Type I Alpha 1 Chain: Click to Expand ⟱
Source:
Type: gene/protein
COL1A1 (Collagen Type I Alpha 1 Chain) is a gene that encodes for a protein that is a component of type I collagen, a major structural protein found in the extracellular matrix of connective tissue.
COL1A1 has been shown to promote tumor growth, invasion, and metastasis by facilitating cell adhesion, migration, and angiogenesis.
Scientific Papers found: Click to Expand⟱
733- Bor,    The analysis of boric acid effect on epithelial-mesenchymal transition of CD133 + CD117 + lung cancer stem cells
- in-vitro, Lung, NA
Snail↑, ITGB1↑, ITGA5↑, COL1A1↓, LAMA5↑, MMP3↓, Vim↓, E-cadherin↑, EMT↓, Zeb1↑,
756- Bor,    Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
COL1A1↓, Vim↓, miR-127-5p↑, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑,
736- Bor,    Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
miR-126↑, COL1A1↓, Vim↓, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑, miR-127-5p↑,
1264- CAP,    Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells
- in-vitro, HCC, NA
TumCP↓, TumCMig↓, TumCCA↑, MMP∅, MMP2↓, MMP9↓, α-SMA↓, COL1A1↓, COL3A1↓, TIMP1↓,
3228- EGCG,    Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids
*cycD1/CCND1↓, *COL1A1↓, *ACTA2↓, *α-SMA↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MMP∅, 1,  

Cell Death ⓘ

miR-127-5p↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

CDH1↑, 2,   COL1A1↓, 4,   COL3A1↓, 1,   E-cadherin↑, 1,   ITGA5↑, 3,   ITGB1↑, 3,   LAMA5↑, 3,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   Snail↑, 3,   TIMP1↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   Vim↓, 3,   Zeb1↑, 3,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

miR-126↑, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Migration ⓘ

ACTA2↓, 1,   COL1A1↓, 1,   α-SMA↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: COL1A1, Collagen Type I Alpha 1 Chain
3 Boron
1 Capsaicin
1 EGCG (Epigallocatechin Gallate)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:864  State#:%  Dir#:%
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