Database Query Results : , , GADD34

GADD34, Growth Arrest and DNA Damage-inducible protein 34: Click to Expand ⟱
Source:
Type:
GADD34 (Growth Arrest and DNA Damage-inducible protein 34) is a protein that plays a crucial role in the regulation of cell growth, apoptosis, and DNA damage response.
GADD34 has been shown to promote tumor growth, invasion, and metastasis by facilitating cell proliferation, survival, and angiogenesis.
GADD34 has been found to be highly expressed in cancer stem cells, which are thought to be responsible for cancer initiation, progression, and recurrence.
Scientific Papers found: Click to Expand⟱
3512- Bor,    Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
- in-vitro, Pca, DU145
TumCP↓, eIF2α↑, ATF4↑, ATF6↑, GADD34↑, CHOP↓, GRP78/BiP↑, GRP94↑, Risk↓, *BMD↑, Ca+2↓, *Half-Life↝, IRE1∅, chemoP↑,
737- Bor,    Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Statu
- in-vitro, Pca, DU145
Risk↓, p‑eIF2α↑, ATF4↑, GADD34↑,
3065- RES,    Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response
- in-vitro, lymphoma, NA
UPR↑, IRE1↑, p‑eIF2α↑, PERK↑, ATF6↑, GRP78/BiP↑, GRP94↑, CHOP↑, GADD34↑, ATF4↑, XBP-1↑, Ca+2↑, ER Stress↑,
4501- Se,    Mechanisms of the Cytotoxic Effect of Selenium Nanoparticles in Different Human Cancer Cell Lines
- in-vitro, GBM, A172 - in-vitro, Colon, Caco-2 - in-vitro, Pca, DU145 - in-vitro, BC, MCF-7 - in-vitro, Nor, L929
*BioAv↑, selectivity↑, AntiCan↑, Apoptosis↑, CHOP↑, GADD34↑, BIM↑, PUMA↑, Ca+2↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   BIM↑, 1,   GADD34↑, 4,   PUMA↑, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 2,   CHOP↓, 1,   CHOP↑, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 1,   GRP78/BiP↑, 2,   GRP94↑, 2,   IRE1↑, 1,   IRE1∅, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Migration ⓘ

Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 3,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,   Risk↓, 2,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: GADD34, Growth Arrest and DNA Damage-inducible protein 34
2 Boron
1 Resveratrol
1 Selenium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:865  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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