Database Query Results : , , GRP94

GRP94, Glucose-Regulated Protein 94: Click to Expand ⟱
Source:
Type:
GRP94 (Glucose-Regulated Protein 94) is a molecular chaperone that plays a crucial role in protein folding, assembly, and quality control in the endoplasmic reticulum (ER). It is also known as GP96 or HSP90B1.
High GRP94 expression(common) is associated with poor prognosis, increased tumor aggressiveness, and reduced overall survival.


Scientific Papers found: Click to Expand⟱
3512- Bor,    Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
- in-vitro, Pca, DU145
TumCP↓, eIF2α↑, ATF4↑, ATF6↑, GADD34↑, CHOP↓, GRP78/BiP↑, GRP94↑, Risk↓, *BMD↑, Ca+2↓, *Half-Life↝, IRE1∅, chemoP↑,
3460- EP,    Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stress and caspase-dependent signaling pathways
- in-vitro, Cerv, HeLa
tumCV↓, Apoptosis↑, TumCCA↑, GRP78/BiP↑, GRP94↑, CEBPA↑, CHOP↑, Ca+2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, BAX↑, Bcl-2↓, ER Stress↑, MMP↓,
839- Gra,    Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway
- in-vitro, Liver, HepG2
tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP↑,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
3459- MF,    EFFECT OF PULSED ELECTROMAGNETIC FIELDS ON ENDOPLASMIC RETICULUM STRESS
- in-vitro, Cerv, HeLa
GRP78/BiP↑, GRP94↑, CHOP↑, ER Stress↓,
3065- RES,    Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response
- in-vitro, lymphoma, NA
UPR↑, IRE1↑, p‑eIF2α↑, PERK↑, ATF6↑, GRP78/BiP↑, GRP94↑, CHOP↑, GADD34↑, ATF4↑, XBP-1↑, Ca+2↑, ER Stress↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics

MMP↓, 2,  

Cell Death

Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp12↑, 2,   Casp3↑, 2,   Casp9↑, 2,   Cyt‑c↑, 2,   GADD34↑, 2,   JNK↓, 1,   p38↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics

tumCV↓, 2,  

Protein Folding & ER Stress

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP↓, 1,   CHOP↑, 5,   eIF2α↑, 1,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 4,   GRP78/BiP↑, 6,   GRP94↑, 6,   HSP70/HSPA5↑, 1,   IRE1↑, 1,   IRE1∅, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Cell Cycle & Senescence

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State

CEBPA↑, 1,   ERK↑, 1,  

Migration

Ca+2↓, 1,   Ca+2↑, 2,   TumCP↓, 1,  

Angiogenesis & Vasculature

ATF4↑, 2,  

Functional Outcomes

chemoP↑, 1,   Risk↓, 1,  
Total Targets: 39

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance

Half-Life↝, 1,  

Clinical Biomarkers

BMD↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: GRP94, Glucose-Regulated Protein 94
1 Boron
1 Electrical Pulses
1 Graviola
1 Luteolin
1 Magnetic Fields
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:905  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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