Database Query Results : , , PTPN6

PTPN6, SHP1/Protein Tyrosine Phosphatase, Non-Receptor Type 6: Click to Expand ⟱
Source:
Type:
Also known as SHP-1 (Src Homology 2 Domain-Containing Phosphatase 1)
SHP-1 (Src homology 2 domain-containing phosphatase-1) is a protein tyrosine phosphatase that plays a crucial role in regulating various cellular processes, including cell signaling, proliferation, and survival. Its expression has been implicated in the development and progression of various types of cancer.
Low SHP-1 expression is associated with poor prognosis, increased tumor size, and lymph node metastasis.
Scientific Papers found: Click to Expand⟱
1187- Gb,    Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
- in-vitro, Melanoma, U251 - in-vitro, Melanoma, MM.1S
STAT3↓, PTEN↑, Apoptosis↑, PTPN6↑,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Mcl-1↓, 1,   survivin↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PTEN↑, 1,   PTPN6↑, 2,   STAT3↓, 1,   p‑STAT3↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PTPN6, SHP1/Protein Tyrosine Phosphatase, Non-Receptor Type 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:923  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page