Database Query Results : , , PGC-1α

PGC-1α, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha: Click to Expand ⟱
Source:
Type: transcriptional coactivator
PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is a transcriptional coactivator that plays a crucial role in regulating cellular energy metabolism, including mitochondrial biogenesis and function. PGC-1α is also involved in various cellular processes, including cell growth, differentiation, and survival.

In some cancers (for example, certain melanomas, breast cancers, and prostate cancers), elevated levels of PGC-1α have been observed.
– Increased PGC-1α may enhance mitochondrial function and support the energetic and biosynthetic demands of tumor cells, especially under metabolic stress or during metastasis.
Scientific Papers found: Click to Expand⟱
3441- ALA,    α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice
- in-vivo, AD, NA
*tau↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, *VEGF↑, *HO-1↑, *Glycolysis↑, *HK1↑, *PGC-1α↑, *Hif1a↑, *neuroP↑,
3635- Croc,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, NA, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
3708- dietSTF,    Fasting as a Therapy in Neurological Disease
*PGC-1α↑, *AMPK↑, *adiP↑, *glucose↓, *Insulin↓, *mTOR↓, *IL6↓, *TNF-α↓, *cognitive↑, *Inflam↓, *eff↑, *neuroP↑, ChemoSen↑, eff↓, chemoP↑, *eff↑,
2395- EGCG,    EGCG inhibits diabetic nephrophathy through up regulation of PKM2
- Study, Diabetic, NA
*PKM2↑, *Apoptosis↓, *PGC-1α↑,
3231- EGCG,    Epigallocatechin-3-gallate restores mitochondrial homeostasis impairment by inhibiting HDAC1-mediated NRF1 histone deacetylation in cardiac hypertrophy
- in-vitro, Nor, NA
*HDAC↓, *cardioP↑, *Nrf1↑, *PGC-1α↓,
3761- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Human, AD, NA
*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,
2505- H2,    Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis
- Trial, CRC, NA
PGC-1α↑, Dose↝, CD8+↑, OS↑,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, asthmatic, NA
selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
2887- HNK,    Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming
- in-vitro, AD, BV2
*Glycolysis↑, *ATP↑, *ROS↓, *MMP↑, *OXPHOS↑, *PPARα↑, *PGC-1α↑,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2872- HNK,    Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis
- in-vivo, ALS, NA - NA, Stroke, NA - NA, AD, NA - NA, Park, NA
*eff↑, *ROS↓, *GSH↑, *NRF2↑, *motorD↑, *OS↑, *neuroP↑, *BBB↑, *cognitive↑, *eff↑, *antiOx↑, *Cyt‑c↑, *PGC-1α↑,
4238- HNK,    Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
- Review, AD, NA - NA, Park, NA
*BDNF↑, *hepatoP↑, *ALAT↓, *AST↓, *TNF-α↓, *SIRT3↑, *Aβ↓, *Apoptosis↓, *ROS↓, *MMP↑, *Ca+2↓, *Casp3↓, *Ach↑, *PPARγ↑, *PGC-1α↑, *motorD↑, *TNF-α↓, *IL1β↓,
2643- MCT,    Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism
- Review, Nor, NA
*Akt↑, *AMPK↓, *TGF-β↓, eff↑, *BioEnh↑, *ATP↑, *PGC-1α↑, *p‑mTOR↑, *SMAD3↓,
2247- MF,    Effects of Pulsed Electromagnetic Field Treatment on Skeletal Muscle Tissue Recovery in a Rat Model of Collagenase-Induced Tendinopathy: Results from a Proteome Analysis
- in-vivo, Nor, NA
*Glycolysis↓, *LDHB↑, *NAD↑, *ATP↑, *antiOx↑, *ROS↑, *YAP/TEAD↑, *PGC-1α↑, *TCA↑, *FAO↑, *OXPHOS↑,
2260- MF,    Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229 - in-vivo, NA, NA
TumCP↓, TumCG↓, OS↑, ROS↑, SOD2↑, eff↓, ECAR↓, OCR↑, selectivity↑, *toxicity∅, TumVol↓, PGC-1α↑, OXPHOS↑, Glycolysis↓, PKM2↓,
2248- MF,    Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc-1α expression: Follow-up to an in vitro magnetic mitohormetic study
- in-vivo, Nor, NA
*PGC-1α↑, *GutMicro↑, *FAO↓, *Insulin↓,
3350- QC,    Quercetin and the mitochondria: A mechanistic view
- Review, NA, NA
*antiOx↑, *Inflam↓, *NRF2↑, ROS⇅, *NRF2↑, *HO-1↑, *PPARα↑, *PGC-1α↑, *SIRT1↑, *ATP↑, ATP↓, ERK↓, cl‑PARP↑, Casp9↑, Casp8↑, BAX↑, MMP↓, Cyt‑c↑, Casp3↑, HSP27↓, HSP72↓, RAS↓, Raf↓,
2472- RES,    Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model
- in-vivo, Nor, NA
*SIRT1↑, *PGC-1α↑, *cMyc↑, *PDK1↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,
942- UA,    Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling
- vitro+vivo, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Cav1↑, Glycolysis↓, cMyc↓, LDHA↓, Nrf1↓, PGC-1α↓, Sp1/3/4↑, TumCG↓,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1↑, *ROS↓, *GutMicro↑, *Risk↓,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,
4034- VitB3,    Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models
- in-vivo, AD, NA
*cognitive↑, *NAD↑, *BACE↓, *Aβ↓, *PGC-1α↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 27

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CoQ10↑, 1,   HO-1↓, 1,   Nrf1↓, 1,   OXPHOS↑, 2,   ROS↑, 1,   ROS⇅, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   ATP↑, 1,   MMP↓, 1,   OCR↑, 2,   PGC-1α↓, 1,   PGC-1α↑, 4,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

Cav1↑, 1,   cMyc↓, 1,   ECAR↓, 2,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   Casp8↑, 2,   Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 2,   DR5↑, 1,   p27↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↑, 1,  

Protein Folding & ER Stress ⓘ

HSP27↓, 1,   HSP72↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   FOXM1↓, 1,   mTOR↓, 1,   PI3K↓, 1,   RAS↓, 2,   TumCG↓, 2,  

Migration ⓘ

MMP2↓, 1,   Rho↑, 1,   ROCK1↑, 1,   TumCMig↓, 1,   TumCP↓, 1,   Twist↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   PDT+↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 3,   eff↓, 2,   eff↑, 3,   eff↝, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

BMPs↑, 1,   FOXM1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,   OS↑, 3,   TumVol↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 2,  
Total Targets: 74

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 2,   antiOx↑, 7,   Catalase↑, 1,   Ferroptosis↓, 1,   GPx↑, 1,   GSH↑, 2,   H2O2↓, 1,   HK1↑, 1,   HO-1↑, 4,   Keap1↑, 1,   lipid-P↓, 2,   mt-lipid-P↓, 1,   MDA↓, 1,   Mets↝, 1,   MPO↓, 1,   NQO1↑, 2,   Nrf1↑, 1,   NRF2↑, 7,   OXPHOS↑, 2,   PARK2↑, 1,   ROS↓, 11,   ROS↑, 1,   mt-ROS↓, 1,   SIRT3↑, 4,   SOD↑, 1,   Thiols↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 5,   Insulin↓, 2,   MMP↑, 5,   PGC-1α↓, 2,   PGC-1α↑, 20,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 4,   cMyc↑, 1,   p‑CREB↑, 1,   FAO↓, 2,   FAO↑, 1,   glucose↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   LDHB↑, 1,   NAD↑, 2,   NADH:NAD↑, 1,   PDK1↓, 1,   PKM2↑, 1,   PPARα↑, 2,   PPARγ↑, 4,   SIRT1↑, 6,   TCA↑, 1,  

Cell Death ⓘ

Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 2,   Cyt‑c↑, 1,   Cyt‑c∅, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   YAP/TEAD↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 2,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↝, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   MitoP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 3,   HDAC↓, 1,   mTOR↓, 2,   p‑mTOR↑, 1,  

Migration ⓘ

AntiAg↑, 2,   Ca+2↓, 2,   MMP9↓, 2,   NFAT↓, 1,   PKA↑, 1,   Rho↓, 1,   SMAD3↓, 1,   TGF-β↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 4,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1↓, 1,   IL1β↓, 5,   IL6↓, 2,   Inflam↓, 9,   NF-kB↓, 6,   p65↓, 1,   TLR4↓, 1,   TNF-α↓, 7,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BDNF↑, 3,   MAOA↝, 1,   tau↓, 1,   p‑tau↓, 3,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 7,   BACE↓, 3,   NLRP3↓, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 1,   BioEnh↑, 1,   Dose↝, 1,   eff↑, 7,   Half-Life↓, 2,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,   GutMicro↑, 2,   IL6↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 3,   cognitive↑, 8,   hepatoP↑, 2,   memory↑, 4,   Mood↑, 1,   motorD↑, 4,   neuroP↑, 11,   OS↑, 2,   Risk↓, 1,   Strength↑, 1,   toxicity↓, 1,   toxicity∅, 2,  
Total Targets: 134

Scientific Paper Hit Count for: PGC-1α, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
5 Honokiol
4 Hydrogen Gas
3 Magnetic Fields
3 Resveratrol
2 EGCG (Epigallocatechin Gallate)
2 Ursolic acid
1 Alpha-Lipoic-Acid
1 Crocetin
1 diet Short Term Fasting
1 MCToil
1 Quercetin
1 Urolithin
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:927  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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