Database Query Results : , , XIST

XIST, X-inactive specific transcript: Click to Expand ⟱
Source:
Type:
XIST (X-inactive specific transcript) is a long non-coding RNA that plays a crucial role in X-chromosome inactivation in females. However, XIST has also been implicated in various types of cancer, where it can be expressed in both males and females.

Direction of Regulation in Cancer 
-XIST is most often functionally DOWNREGULATED or LOST in cancer, particularly in aggressive tumors from female patients.
-This loss is usually epigenetic or structural, not due to point mutation.

XIST acts as a guardian of chromosomal dosage stability, not a classical tumor suppressor gene.


Scientific Papers found: Click to Expand⟱
985- ART/DHA,    Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway
- in-vitro, Thyroid, TPC-1 - Human, NA, NA
XIST↓, Hif1a↓, Glycolysis↓, TumCCA↑, TumMeta↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Clinical Biomarkers ⓘ

XIST↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: XIST, X-inactive specific transcript
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:940  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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