Database Query Results : , , PFK

PFK, Phosphofructokinase: Click to Expand ⟱
Source:
Type:
PFK (Phosphofructokinase) is a key enzyme in glycolysis, the process by which cells convert glucose into energy. PFK is overexpressed in many types of cancer, and its expression is often associated with poor prognosis.
Mechanisms:
• PFK promotes glycolysis, which is a key metabolic pathway in cancer cells.
• PFK helps to produce energy for cancer cells.
• PFK promotes cell proliferation.

Therapeutic Targeting:
• PFK inhibitors are being developed as a potential therapeutic strategy for cancer treatment.
• Inhibitors of glycolysis, such as 2-deoxyglucose, are being explored as a potential therapeutic strategy for cancer treatment.
Scientific Papers found: Click to Expand⟱
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
1579- Citrate,    Effect of Food Additive Citric Acid on The Growth of Human Esophageal Carcinoma Cell Line EC109
- in-vitro, ESCC, Eca109
TumCP↓, e-LDH↑, MMP↓, Ca+2?, PFK↓, Glycolysis↓,
1593- Citrate,    Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
989- EGCG,  Citrate,    In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- in-vitro, HCC, NA - in-vivo, NA, NA
PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,
2309- EGCG,  Chemo,    Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HPNE - in-vitro, PC, PANC1 - in-vivo, NA, NA
TumCG↓, eff↑, ROS↑, ECAR↓, ChemoSen↑, selectivity↑, Glycolysis↓, PFK↓, PKA↓, HK2∅, LDHA∅, PFKP↓, PKM2↓, H2O2↑, TumW↓,
2302- EGCG,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCP↓, Hif1a↓, LDHA↓, PFK↓, cardioP↑, Glycolysis↓, PKM2↓,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, asthmatic, NA
selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,
991- OA,    Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells
- in-vivo, NA, NA - in-vivo, Nor, NA
*Glycolysis↓, *GlucoseCon↓, *lactateProd↓, *ECAR↓, *HK2↓, *PFK↓, *PKM2↓, *LDHA↓,
2396- PACs,    PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
- in-vitro, HCC, HCCLM3 - in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402 - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2 - in-vitro, Nor, L02
TumCP↓, TumCCA↓, Apoptosis↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, HK2↓, PFK↓, OXPHOS↑, ChemoSen↑, HSP90↓, Hif1a↓,
2382- PBG,    Integration with Transcriptomic and Metabolomic Analyses Reveals the In Vitro Cytotoxic Mechanisms of Chinese Poplar Propolis by Triggering the Glucose Metabolism in Human Hepatocellular Carcinoma Cells
- in-vitro, HCC, HepG2
TumCP↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GLUT1↓, GLUT2↓, LDHA↓, HK2↓, PKM2↓, PFK↓, Dose↝,
2381- PBG,    Chinese Poplar Propolis Inhibits MDA-MB-231 Cell Proliferation in an Inflammatory Microenvironment by Targeting Enzymes of the Glycolytic Pathway
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, IL1β↓, IL6↓, NLRP3↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ROS↑, MMP↓,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1661- PBG,    Propolis: a natural compound with potential as an adjuvant in cancer therapy - a review of signaling pathways
- Review, Var, NA
JNK↓, ERK↓, Akt↓, NF-kB↓, FAK↓, MAPK↓, PI3K↓, Akt↓, P21↑, p27↑, TRAIL↑, BAX↑, P53↑, ERK↓, ChemoSen↑, RadioS↑, Glycolysis↓, HK2↓, PKM2↓, LDHA↓, PFK↓,
1231- PBG,    Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, MMP↓, TLR4↓, TNF-α↓, NF-kB↓, IL1β↓, IL6↓, IRAK4↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ACC↓, FASN↓, eff↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF-7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
1913- Xyl,    Partial Substitution of Glucose with Xylitol Prolongs Survival and Suppresses Cell Proliferation and Glycolysis of Mice Bearing Orthotopic Xenograft of Oral Cancer
- in-vivo, Oral, NA
TumVol↓, OS↑, PFK↓, toxicity↓, Dose∅, Ki-67↓,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF-7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↑, 1,   lipid-P↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   ROS↑, 17,   SIRT3↑, 1,   TKT↝, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 5,   ATP↑, 1,   mitResp↓, 1,   MMP↓, 9,   mtDam↑, 2,   OCR↓, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ACLY↓, 1,   AMPK↑, 2,   p‑AMPK↑, 1,   cMyc↓, 2,   ECAR↓, 2,   FASN↓, 2,   FBPase↑, 1,   G6PD↓, 1,   GLS↓, 1,   glucoNG↑, 1,   GlucoseCon↓, 6,   GLUT2↓, 2,   GlutMet↓, 1,   Glycolysis↓, 15,   HK2↓, 13,   HK2∅, 1,   lactateProd↓, 6,   LDH↓, 5,   e-LDH↑, 1,   LDHA↓, 8,   LDHA∅, 1,   NAD↓, 1,   NADPH↓, 1,   PDH↓, 2,   PDH↑, 1,   PFK↓, 19,   PFK1↓, 1,   PFKP↓, 1,   PKM2↓, 12,   PKM2∅, 1,   POLD1↓, 1,   R5P↝, 1,   SIRT1↑, 2,   TCA↓, 1,   Warburg↓, 1,   β-oxidation↓, 1,  

Cell Death ⓘ

Akt↓, 5,   Apoptosis?, 1,   Apoptosis↑, 6,   BAD↑, 1,   BAX↓, 2,   BAX↑, 2,   Bcl-2↓, 2,   Casp3↓, 1,   Casp3↑, 1,   cl‑Casp3↑, 2,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↑, 1,   CK2↓, 1,   Cyt‑c↑, 1,   Cyt‑c↝, 1,   hTERT/TERT↓, 1,   iNOS↑, 1,   JNK↓, 1,   MAPK↓, 1,   Mcl-1↓, 1,   p27↑, 2,   PUMA↑, 1,   TRAIL↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   LC3B-II↑, 1,   LC3II↑, 1,   p62↓, 2,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   cl‑PARP↑, 3,   TP53↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   p‑CDK1↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   P21↓, 1,   P21↑, 3,   TumCCA↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD24↓, 1,   CD44↓, 1,   CSCs↓, 2,   EMT↓, 1,   ERK↓, 2,   FOXO3↓, 1,   FOXO4↓, 1,   GSK‐3β↓, 1,   HDAC8↓, 1,   IGF-1↓, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 3,   STAT3↓, 1,   TumCG↓, 3,   TumCG↑, 1,  

Migration ⓘ

Ca+2?, 1,   i-Ca+2↑, 1,   CLDN2↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 2,   MMP2↓, 1,   MMP9↓, 1,   PKA↓, 1,   Slug↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   talin↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 10,   TumMeta↓, 1,   Vim?, 1,   Zeb1↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   eNOS↑, 1,   Hif1a↓, 6,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 4,   GLUT3↓, 2,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   IL10↓, 2,   IL1β↓, 3,   IL4↓, 1,   IL6↓, 2,   Inflam↓, 1,   IRAK4↓, 1,   NF-kB↓, 4,   p‑NF-kB↓, 1,   p65↓, 1,   PD-1↓, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 2,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↓, 1,   ChemoSen↑, 5,   Dose↝, 2,   Dose∅, 3,   eff↓, 2,   eff↑, 13,   RadioS↑, 4,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

CRP↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 2,   LDH↓, 5,   e-LDH↑, 1,   TP53↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   OS↑, 2,   toxicity↓, 1,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 189

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 1,   Keap1↓, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 1,   mt-ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   FGF21↑, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   H2S↑, 1,   HK2↓, 1,   HK2↑, 1,   lactateProd↓, 1,   LDHA↓, 1,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PPARα↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   mTOR↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,  

Barriers & Transport ⓘ

GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 1,   neuroP↑, 2,   OS↑, 1,  
Total Targets: 36

Scientific Paper Hit Count for: PFK, Phosphofructokinase
6 Propolis -bee glue
3 Citric Acid
3 EGCG (Epigallocatechin Gallate)
2 Resveratrol
1 Alpha-Lipoic-Acid
1 Caffeic acid
1 Metformin
1 diet Methionine-Restricted Diet
1 Chemotherapy
1 Hydrogen Gas
1 Oroxylin-A
1 Proanthocyanidins
1 Xylitol
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:945  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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