Database Query Results : , , ACSL5

ACSL5, (Acyl-CoA Synthetase Long Chain Family Member 5: Click to Expand ⟱
Source:
Type:
The ACSL5 gene (Acyl-CoA Synthetase Long Chain Family Member 5) is a key regulator of fatty acid metabolism, particularly in the activation of long-chain fatty acids. The ACSL5 gene is overexpressed in various types of cancer.

ACSL5 gene is a key regulator of fatty acid metabolism and is overexpressed in various types of cancer. Its expression is associated with poor prognosis and increased risk of metastasis and recurrence.
Scientific Papers found: Click to Expand⟱
1009- And,  5-FU,    Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
- in-vivo, CRC, HCT116 - in-vitro, CRC, SW480
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GCLC↑, 1,   GCLM↑, 1,  

Metal & Cofactor Biology ⓘ

FTL↑, 1,   STEAP3↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL5↑, 2,   SAT1↑, 1,  

Cell Death ⓘ

Casp9↑, 1,   Ferroptosis↑, 1,  

DNA Damage & Repair ⓘ

TP53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Wnt/(β-catenin)↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

TP53↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ACSL5, (Acyl-CoA Synthetase Long Chain Family Member 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:962  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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