Database Query Results : , , L-sel

L-sel, L‑selectin/CD62L: Click to Expand ⟱
Source:
Type:
Also known as CD62L
CD62L is a cell adhesion molecule expressed mainly on leukocytes (e.g., naïve and central memory T cells, B cells, and some neutrophils).
• It mediates lymphocyte homing to lymph nodes and can be involved in leukocyte recruitment to inflammatory sites.
• CD62L can be shed from the cell surface, leading to a soluble form detectable in plasma. In some cancer settings, elevated soluble CD62L has been associated with tumor progression.

Lower expression usually associated with poorer outcomes.
Scientific Papers found: Click to Expand⟱
1043- MET,  immuno,    Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
- in-vitro, NA, NA
eff↑, PD-L1↓, Ki-67↑, TIM-3↑, L-sel↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

Ki-67↑, 1,   L-sel↑, 1,  

Immune & Inflammatory Signaling ⓘ

PD-L1↓, 1,  

Cellular Microenvironment ⓘ

TIM-3↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

Ki-67↑, 1,   PD-L1↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: L-sel, L‑selectin/CD62L
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:974  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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