Database Query Results : , , P2X7

P2X7, purinoceptor 7: Click to Expand ⟱
Source:
Type:
Purinoceptor 7 (commonly referred to as P2X7 when discussing purinergic receptors, though note that P2X7 is an ATP-gated ion channel; if referring to a distinct purinoceptor termed “purinoceptor 7”
– Purinergic receptors are activated by extracellular nucleotides (e.g., ATP). In the context of P2X7, it is an ATP-gated ion channel that opens upon binding high concentrations of ATP.
– This receptor’s activation allows the flow of ions (such as Ca²⁺, Na⁺, and K⁺) across the plasma membrane, thereby initiating intracellular signaling cascades.

Cell Death and Proliferation:
– Prolonged or high-level activation of P2X7 can induce a form of programmed cell death (apoptosis or pyroptosis) by forming membrane pores.
– Conversely, under controlled conditions, P2X7 activation may promote cell proliferation and survival by triggering downstream signaling pathways responsible for growth and differentiation.

– Elevated expression of P2X7 has been documented in several cancer types, including breast, prostate, colorectal, and hematologic malignancies.
– Upregulation in tumor cells may occur either as an adaptive mechanism to the high extracellular ATP levels often found in the tumor microenvironment or as part of oncogenic signaling pathways. – In several studies, high P2X7 expression has been correlated with aggressive tumor behavior, metastasis, and reduced overall survival.

Dual-Edge Effects:
– In certain circumstances, activation of P2X7 leading to cell death may actually have antitumor effects.
Scientific Papers found: Click to Expand⟱
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumAuto↑, TumCI↓, IL1↓, IL6↓, TNF-α↓, LDH↓, P2X7↓, proCasp1↓, Casp1↓, ASC↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

LDH↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp1↓, 1,   proCasp1↓, 1,   P2X7↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

TumCI↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   IL1↓, 1,   IL6↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,   LDH↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: P2X7, purinoceptor 7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:995  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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