Pterostilbene Cancer Research Results

PTS, Pterostilbene: Click to Expand ⟱

Features:

Antioxidant found in blueberries, cranberries and grapes.
Pterostilbene (trans-3,5-dimethoxy-40-hydroxystilbene) is a naturally occurring stilbene, found mainly in blueberries and grapes. It is a dimethylated derivative of resveratrol with comparable antioxidant, anti-inflammatory and anticarcinogenic properties [26].
-more bioavailable than resveratrol
-Antioxidant activity: Reduces reactive oxygen species and lipid peroxidation
-Anti-inflammatory: Downregulates pro-inflammatory cytokines- IL-1β, TNF-α, NF-κB
-Amyloid pathology:inhibits Aβ aggregation and promotes clearance- Aβ, APP, BACE1
-Reduces hyperphosphorylation of tau protein
-Inhibits histone deacetylases (HDACs)
-Increases acetylcholine by inhibiting acetylcholinesterase
-Sirtuin activation

Rank	Pathway / Axis	Cancer Cells	Normal Cells	Label	Primary Interpretation	Notes
1	SIRT1 / AMPK metabolic sensing	↑ AMPK; context-dependent SIRT1 modulation	↑ SIRT1 / ↑ AMPK	Driver	Energy-stress signaling	Pterostilbene strongly engages energy-sensing pathways due to high bioavailability
2	PI3K → AKT → mTOR axis	↓ AKT / ↓ mTOR	↔ adaptive suppression	Driver	Growth and survival inhibition	AKT/mTOR suppression explains cytostatic and pro-apoptotic effects in cancer cells
3	Reactive oxygen species (ROS)	↑ ROS (mild, dose-dependent)	↓ ROS / buffered	Conditional Driver	Biphasic redox modulation	More balanced redox profile than resveratrol; weaker pro-oxidant behavior
4	Mitochondrial integrity / intrinsic apoptosis	↓ ΔΨm; ↑ caspase activation	↔ preserved	Secondary	Execution of apoptosis	Mitochondrial apoptosis follows metabolic and redox stress
5	NF-κB signaling	↓ NF-κB activation	↓ inflammatory NF-κB tone	Secondary	Suppression of inflammatory survival programs	NF-κB inhibition contributes to anti-invasive and chemosensitizing effects
6	Cell cycle regulation	↑ G1 or G2/M arrest	↔ spared	Phenotypic	Cytostatic growth control	Cell-cycle arrest reflects upstream metabolic and signaling effects
7	NRF2 antioxidant response	↑ NRF2 (adaptive)	↑ NRF2 (protective)	Adaptive	Redox compensation	NRF2 activation contributes to stress buffering rather than primary cytotoxicity

Scientific Papers found: Click to Expand⟱

4699-

PTS,

Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

HS587T

in-vivo,

BC,

MDA-MB-231

NOD/SCID mice b

"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >E-cadherin↑, "highlight2" >Snail↓, "highlight2" >Slug↓, "highlight2" >Vim↓, "highlight2" >Zeb1↑, "highlight2" >miR-205↑, "highlight2" >Src↓, "highlight2" >TumCG↓, "highlight2" >FAK↓, "highlight2" >EMT↓,

4690-

PTS,

immuno,

Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies

Review,

Var,

"highlight2" >eff↑, "highlight2" >Half-Life↑, "highlight2" >TumCG↓, "highlight2" >TumMeta↓, "highlight2" >angioG↓, "highlight2" >CSCs↓, "highlight2" >Apoptosis↑, "highlight2" >eff↑, "highlight2" >CD44↓, "highlight2" >CD24↓,

4691-

PTS,

Pterostilbene as a Potent Chemopreventive Agent in Cancer

"highlight2" >ChemoSen↑, "highlight2" >BioAv↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >AntiCan↑,

4692-

PTS,

Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol

in-vitro,

Cerv,

HeLa

"highlight2" >TumCG↓, "highlight2" >TumMeta↓, "highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >CD133↓, "highlight2" >OCT4↓, "highlight2" >SOX2↓, "highlight2" >Nanog↓, "highlight2" >STAT3↓, "highlight2" >CSCs↓,

4693-

PTS,

Pterostilbene in the treatment of inflammatory and oncological diseases

"highlight2" >BioAv↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >AntiTum↑, "highlight2" >BBB↑, "highlight2" >Half-Life↝, "highlight2" >*ROS↓, "highlight2" >*NRF2↑, "highlight2" >*NQO1↑, "highlight2" >*HO-1↑, "highlight2" >PTEN↑, "highlight2" >miR-19b↓, "highlight2" >TumCCA↑, "highlight2" >ER Stress↑, "highlight2" >PERK↑, "highlight2" >ATF4↑, "highlight2" >CHOP↑, "highlight2" >Ca+2↝, "highlight2" >EMT↓, "highlight2" >NF-kB↓, "highlight2" >Twist↓, "highlight2" >Vim↓, "highlight2" >E-cadherin↑, "highlight2" >ChemoSen↑, "highlight2" >toxicity∅, "highlight2" >toxicity↝,

4694-

PTS,

Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions

"highlight2" >BioAv↑, "highlight2" >AntiCan↑, "highlight2" >Casp↑, "highlight2" >TumCCA↑, "highlight2" >angioG↓, "highlight2" >TumMeta↓, "highlight2" >MMP9↓, "highlight2" >VEGF↓, "highlight2" >CSCs↓, "highlight2" >CD44↓, "highlight2" >cMyc↓, "highlight2" >ChemoSen↑, "highlight2" >mTOR↓,

4695-

PTS,

Pterostilbene in Cancer Therapy: Enhancing Treatment Efficacy and Overcoming Resistance

Review,

Var,

"highlight2" >CSCs↓, "highlight2" >ChemoSen↑, "highlight2" >BioAv↑, "highlight2" >*toxicity↓,

4696-

PTS,

BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells

in-vitro,

HCC,

"highlight2" >CD133↓, "highlight2" >CSCs↓,

4697-

PTS,

Pterostilbene and cancer: current review

Review,

Var,

"highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >TumMeta↑, "highlight2" >toxicity↓, "highlight2" >BioAv↑,

4698-

PTS,

Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF ‐κ B /microRNA 448 circuit

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

"highlight2" >CSCs↓, "highlight2" >NF-kB↓, "highlight2" >Twist↓, "highlight2" >Vim↓, "highlight2" >E-cadherin↑, "highlight2" >miR-448↑,

4689-

PTS,

Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol

"highlight2" >eff↑, "highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >CSCs↓, "highlight2" >CD133↓, "highlight2" >OCT4↓, "highlight2" >SOX2↓, "highlight2" >Nanog↓, "highlight2" >STAT3↓, "highlight2" >BioAv↑, "highlight2" >TumCI↓, "highlight2" >ROS↑, "highlight2" >Apoptosis↑,

4700-

PTS,

Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF-7

"highlight2" >CSCs↓, "highlight2" >NF-kB↓, "highlight2" >Twist↓, "highlight2" >Vim↓, "highlight2" >E-cadherin↑,

4701-

PTS,

RES,

Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene

Review,

Var,

"highlight2" >CSCs↓, "highlight2" >E-cadherin↑, "highlight2" >NF-kB↓, "highlight2" >EMT↓, "highlight2" >GRP78/BiP↓, "highlight2" >CD133↓, "highlight2" >COX2↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >NOTCH↓,

4702-

PTS,

Pterostilbene Inhibits Pancreatic Cancer In Vitro

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

PANC1

"highlight2" >tumCV↓, "highlight2" >TumCG↓, "highlight2" >BioAv↑,

4703-

PTS,

RES,

Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging - A scoping review

NA,

Nor,

"highlight2" >*AntiAge↑, "highlight2" >*eff↑, "highlight2" >*Inflam↓, "highlight2" >*AntiCan↑, "highlight2" >*ROS↓, "highlight2" >*Catalase↑, "highlight2" >*GSR↑, "highlight2" >*HO-1↑, "highlight2" >*NAD↑, "highlight2" >*NQO1↑, "highlight2" >*SOD↑, "highlight2" >*NRF2↑,

4704-

PTS,

Cisplatin,

Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS

in-vitro,

Bladder,

"highlight2" >PI3K↓, "highlight2" >mTOR↓, "highlight2" >P70S6K↓, "highlight2" >MEK↑, "highlight2" >ERK↑, "highlight2" >ChemoSen↑, "highlight2" >TumAuto↑,

5032-

PTS,

Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism

in-vivo,

Melanoma,

melanomas), growing in nude mice as xenografts,

"highlight2" >TumCG↓, "highlight2" >NRF2↓, "highlight2" >GR↓, "highlight2" >BBB↑, "highlight2" >ACTH↓, "highlight2" >eff↑,

5033-

PTS,

Involvement of the Nrf2 Pathway in the Regulation of Pterostilbene-Induced Apoptosis in HeLa Cells via ER Stress

in-vitro,

Cerv,

HeLa

"highlight2" >ER Stress↑, "highlight2" >ROS↑, "highlight2" >NRF2↑, "highlight2" >TumCP↓, "highlight2" >GSH/GSSG↓,

5034-

PTS,

Pterostilbene in Cancer Therapy

Review,

Var,

"highlight2" >BioAv↓, "highlight2" >Half-Life↓, "highlight2" >iNOS↓, "highlight2" >Apoptosis↑, "highlight2" >STAT3↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >NF-kB↓, "highlight2" >NRF2↓, "highlight2" >ChemoSen↑, "highlight2" >BBB↑,

3923-

PTS,

Pterostilbene Supplement Benefits: Longevity Miracle or Hoax

Review,

AD,

"highlight2" >*BioAv↑, "highlight2" >*Half-Life↑, "highlight2" >*BBB↑, "highlight2" >*BP↓, "highlight2" >*cognitive↑,

1236-

PTS,

Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness

in-vitro,

BC,

MCF-7

20, 30 and 40 µM

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

"highlight2" >TumMeta↓, "highlight2" >EMT↓, "highlight2" >E-cadherin↑, "highlight2" >Zeb1↓, "highlight2" >Snail↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >CD44↓, "highlight2" >MMPs↓, "highlight2" >CSCs↓,

1237-

PTS,

Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade

in-vitro,

Ovarian,

SKOV3

50 µM

"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >MDA↑, "highlight2" >ROS↑, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >Bcl-2↓, "highlight2" >SREBP1↓, "highlight2" >FASN↓, "highlight2" >AMPK↓, "highlight2" >p‑AMPK↑, "highlight2" >p‑P53↑, "highlight2" >p‑TSC2↑, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓, "highlight2" >p‑S6K↓, "highlight2" >p‑4E-BP1↓,

1238-

PTS,

Pterostilbene suppresses gastric cancer proliferation and metastasis by inhibiting oncogenic JAK2/STAT3 signaling: In vitro and in vivo therapeutic intervention

in-vitro,

GC,

in-vivo,

NA,

xenograft tumor model

"highlight2" >TumCCA↑, "highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >TumVol↓, "highlight2" >TumW↓, "highlight2" >Weight∅, "highlight2" >JAK2↓, "highlight2" >STAT3↓,

2408-

PTS,

Pterostilbene suppresses the growth of esophageal squamous cell carcinoma by inhibiting glycolysis and PKM2/STAT3/c-MYC signaling pathway

in-vitro,

ESCC,

"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >PKA↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >PKM2↓, "highlight2" >STAT3↓, "highlight2" >cMyc↓,

2409-

PTS,

Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway

in-vitro,

BC,

EMT6

 0, 20, 40, 60, and 80 µM of PTE for 24, 48, and 72 h

in-vitro,

BC,

4T1

in-vitro,

Nor,

HC11

"highlight2" >Pyro↑, "highlight2" >Glycolysis↓, "highlight2" >*toxicity∅, "highlight2" >selectivity↑, "highlight2" >GSDMC↑, "highlight2" >PKM2↓, "highlight2" >PKM1↑, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >ATP↓, "highlight2" >TumCG↓,

3918-

PTS,

Pterostilbene inhibits amyloid-β-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway

in-vitro,

AD,

BV2

"highlight2" >*IL6↓, "highlight2" >*IL1β↓, "highlight2" >*TNF-α↓, "highlight2" >*NLRP3↓, "highlight2" >*Inflam↓, "highlight2" >*NO↓, "highlight2" >*iNOS↓,

3919-

PTS,

Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease

in-vivo,

AD,

SAMP8 mouse

"highlight2" >*cognitive↑, "highlight2" >*SIRT1∅, "highlight2" >*PPARα↑, "highlight2" >*SOD2↑, "highlight2" >*JNK↓, "highlight2" >*p‑tau↓,

3920-

PTS,

Resveratrol, pterostilbene, and dementia

Review,

AD,

"highlight2" >*cognitive↑,

3922-

PTS,

Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway

in-vivo,

AD,

APP/PS1 mice (AD model)

"highlight2" >*BioAv↑, "highlight2" >*BBB↑, "highlight2" >*memory↑, "highlight2" >*p‑CREB↑, "highlight2" >*BDNF↑, "highlight2" >*PSD95↑, "highlight2" >*neuroP↑,

3924-

PTS,

Effect of resveratrol and pterostilbene on aging and longevity

Review,

AD,

Review,

Stroke,

"highlight2" >*antiOx↓, "highlight2" >*ROS↑, "highlight2" >*SOD↑, "highlight2" >*GSH↑, "highlight2" >*NRF2↑, "highlight2" >*MDA↓, "highlight2" >*HNE↓, "highlight2" >*Inflam↓, "highlight2" >*MAPK↓, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓, "highlight2" >*HO-1↑, "highlight2" >*cardioP↑, "highlight2" >*neuroP↑, "highlight2" >*CRM↑, "highlight2" >*NLRP3↓,

3925-

PTS,

Analysis of Safety from a Human Clinical Trial with Pterostilbene

Trial,

NA,

"highlight2" >*toxicity↓, "highlight2" >*Half-Life↑, "highlight2" >*BioAv↑,

3926-

PTS,

Pterostilbene exert an anti-arthritic effect by attenuating inflammation, oxidative stress, and alteration of gut microbiota

in-vivo,

Arthritis,

"highlight2" >*Inflam↓, "highlight2" >*GutMicro↑, "highlight2" >*ROS↓,

3927-

PTS,

Effects of Pterostilbene on Cardiovascular Health and Disease

Review,

AD,

Review,

Stroke,

"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*BioAv↑, "highlight2" >*toxicity↓, "highlight2" >*NADPH↓, "highlight2" >*ROS↓, "highlight2" >*Catalase↑, "highlight2" >*GSH↑, "highlight2" >*SOD↑, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*IL4↓, "highlight2" >*MMPs↓, "highlight2" >*COX2↓, "highlight2" >*MAPK↝, "highlight2" >*NF-kB↓, "highlight2" >*IL8↓, "highlight2" >*MCP1↓, "highlight2" >*E-sel↓, "highlight2" >*lipid-P↓, "highlight2" >*NRF2↑, "highlight2" >*PPARα↑, "highlight2" >*LDL↓, "highlight2" >other↓,

3928-

PTS,

The effects of pterostilbene on neutrophil activity in experimental model of arthritis

in-vivo,

Arthritis,

Lewis rats

"highlight2" >*ROS↓, "highlight2" >*Neut↓,

3929-

PTS,

New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects

Review,

Var,

Review,

Arthritis,

"highlight2" >*NRF2↑, "highlight2" >*BioAv↑, "highlight2" >*ROS↓, "highlight2" >*Inflam↓, "highlight2" >*HO-1↑, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*GPx↑, "highlight2" >*lipid-P↓, "highlight2" >*hepatoP↑, "highlight2" >*neuroP↑, "highlight2" >*iNOS↓, "highlight2" >*COX2↓, "highlight2" >TumMeta↓, "highlight2" >SOD2↓, "highlight2" >ROS↑, "highlight2" >TumCI↓, "highlight2" >TumCG↓, "highlight2" >HDAC1↓, "highlight2" >PTEN↑, "highlight2" >BP↓, "highlight2" >*GutMicro↑,

3930-

PTS,

A Review of Pterostilbene Antioxidant Activity and Disease Modification

Review,

Var,

Review,

adrenal,

Review,

Stroke,

"highlight2" >*BioAv↑, "highlight2" >*antiOx↑, "highlight2" >*neuroP↑, "highlight2" >*Inflam↓, "highlight2" >*ROS↓, "highlight2" >*H2O2↓, "highlight2" >*GSH↑, "highlight2" >*GPx↑, "highlight2" >*GSR↑, "highlight2" >*SOD↑, "highlight2" >TumCG↓, "highlight2" >PTEN↑, "highlight2" >HGF/c-Met↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >NF-kB↓, "highlight2" >TumMeta↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >Ki-67↓, "highlight2" >Casp3↑, "highlight2" >MMP↓, "highlight2" >H2O2↑, "highlight2" >ROS↑, "highlight2" >ChemoSen↑, "highlight2" >*cardioP↑, "highlight2" >*CDK2↓, "highlight2" >*CDK4↓, "highlight2" >*cycE/CCNE↓, "highlight2" >*cycD1/CCND1↓, "highlight2" >*RB1↓, "highlight2" >*PCNA↓, "highlight2" >*CREB↑, "highlight2" >*GABA↑, "highlight2" >*memory↑, "highlight2" >*IGF-1↑, "highlight2" >*ERK↑, "highlight2" >TIMP1↑, "highlight2" >BAX↑, "highlight2" >Cyt‑c↑, "highlight2" >Diablo↑, "highlight2" >SOD2↑,

3931-

PTS,

Pterostilbene Protects against Osteoarthritis through NLRP3 Inflammasome Inactivation and Improves Gut Microbiota as Evidenced by In Vivo and In Vitro Studies

in-vivo,

Arthritis,

OA mouse

"highlight2" >*Inflam↓, "highlight2" >*NLRP3↓, "highlight2" >*GutMicro↑, "highlight2" >*lipid-P↓, "highlight2" >*ROS↓, "highlight2" >*Cartilage↑, "highlight2" >*IL6↓, "highlight2" >*MMP13↓, "highlight2" >*Dose↝,

884-

RES,

PTS,

Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells

in-vitro,

Cerv,

HeLa

pterostilbene displayed a 1.97-fold lower IC50 when compared to resveratrol (42.3 µM vs. 83.5 µM

"highlight2" >TumCD↑, "highlight2" >TumCCA↑, "highlight2" >E6↓, "highlight2" >Casp3↑, "highlight2" >P53↑,

Showing Research Papers: 1 to 38 of 38

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 38

Pathway results for Effect on Normal Cells:

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:139  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Pterostilbene Cancer Research Results

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

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