Resveratrol Cancer Research Results

RES, Resveratrol: Click to Expand ⟱
Features: polyphenol
Found in red grapes and products made with grapes.
Resveratrol is a polyphenol compound found in various plant species, including grapes, berries, and peanuts.
• Anti-inflammatory effects, Antioxidant effects:
- Antiplatelet aggregation for stroke prevention
- BioAvialability use piperine
- some sources may use Japanese knotweed roots (Reynoutria Japonica - root) as source which might contain Emodin (laxative)
-known as Nrf2 activator, both in cancer and normal cells. Which raises controversity of use in ROS↑ therapies. Interestingly there are reports of NRF2↑ and ROS↑ in cancer cells. This raises the question of if it is a chemosensitizer. However other reports indicate NRF2 droping with Res, indicating it maybe a chemosenstizer.
- RES is also considered to be them most effective natural SIRT1↑ -activating compound (STACs).

However, in the presence of certain metals, such as copper or iron, resveratrol can undergo a process called Fenton reaction, which can lead to the generation of reactive oxygen species (ROS). The pro-oxidant effects of resveratrol are often observed at high concentrations, typically above 50-100 μM, and in the presence of certain metals or other pro-oxidant agents. In contrast, the antioxidant effects of resveratrol are typically observed at lower concentrations, typically below 10-20 μM.

Clinical trials have used doses ranging from 150 mg to 5 grams per day. Lower doses (< 1 g/day) are often well-tolerated, but higher doses might be necessary for therapeutic effects and can be associated with side effects.

-Note half-life 1-3 hrs?.
BioAv poor: min 5uM/L required for chemopreventive effects, but 25mg Oral only yeilds 20nM. co-administration of piperine
Pathways:
- usually induce ROS production in cancer cells, while reducing ROS in normal cells.
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, UPR↑, GRP78↑, Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓,
- Lowers AntiOxidant defense in Cancer Cells: NRF2(typically increased), TrxR↓**, SOD↓, GSH↓ Catalase↓ HO1↓(wrong direction), GPx↓
- Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : NLRP3↓, IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, TIMP2, IGF-1↓, uPA↓, VEGF↓, ROCK1↓, FAK↓, RhoA↓, NF-κB↓, CXCR4↓, SDF1↓, TGF-β↓, α-SMA↓, ERK↓
- reactivate genes thereby inhibiting cancer cell growth : HDAC↓, EZH2↓, P53↑, HSP↓, Sp proteins↓,
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, FAK↓, ERK↓, EMT↓, TOP1↓, TET1↓,
- inhibits glycolysis /Warburg Effect and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDH↓, LDHA↓, HK2↓, PFKs↓, PDKs↓, ECAR↓, OXPHOS↓, GRP78↑, Glucose↓, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, FGF↓, PDGF↓, EGFR↓, Integrins↓,
- inhibits Cancer Stem Cells : CSC↓, CK2↓, Hh↓, CD133↓, CD24↓, β-catenin↓, sox2↓, notch2↓, nestin↓, OCT4↓,
- Others: PI3K↓, AKT↓, JAK↓, STAT↓, Wnt↓, β-catenin↓, AMPK, ERK↓, JNK,
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,

- Selectivity: Cancer Cells vs Normal Cells

Rank Pathway / Axis Cancer Cells Normal Cells Label Primary Interpretation Notes
1 Reactive oxygen species (ROS) ↑ ROS (dose- & context-dependent) ↓ ROS / buffered Conditional Driver Biphasic redox modulation Resveratrol can act as a pro-oxidant in cancer cells while functioning as an antioxidant in normal cells
2 Mitochondrial integrity / intrinsic apoptosis ↓ ΔΨm; ↑ caspase activation ↔ preserved Driver Execution of intrinsic apoptosis Mitochondrial dysfunction and apoptosis follow ROS elevation in cancer cells
3 SIRT1 / AMPK axis ↑ AMPK; context-dependent SIRT1 modulation ↑ SIRT1 / ↑ AMPK Driver Metabolic stress signaling Resveratrol modulates energy-sensing pathways affecting survival and metabolism
4 PI3K → AKT → mTOR axis ↓ AKT / ↓ mTOR ↔ adaptive suppression Secondary Growth and anabolic inhibition Downregulation of growth signaling contributes to cytostasis and apoptosis sensitization
5 NF-κB signaling ↓ NF-κB activation ↓ inflammatory NF-κB tone Secondary Suppression of survival and inflammatory transcription NF-κB inhibition contributes to reduced proliferation and invasion
6 Cell cycle regulation ↑ G1/S or G2/M arrest ↔ largely spared Phenotypic Cytostatic growth control Cell-cycle arrest reflects upstream signaling disruption
7 HIF-1α / VEGF axis ↓ HIF-1α; ↓ VEGF ↔ minimal Secondary Anti-angiogenic pressure Interference with hypoxia-driven adaptation and angiogenesis


Scientific Papers found: Click to Expand⟱
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
"highlight2" >*hepatoP↑, "highlight2" >*Inflam↓, "highlight2" >*NF-kB↓, "highlight2" >*VEGF↓, "highlight2" >*SIRT1↑, "highlight2" >*ROS↓, "highlight2" >*Dose↝, "highlight2" >*Catalase↑, "highlight2" >*MDA↓, "highlight2" >*MPO↓, "highlight2" >*NO↓, "highlight2" >*ALAT↓, "highlight2" >*AST↓, "highlight2" >*antiOx↑,
2578- ART/DHA,  RES,    Synergic effects of artemisinin and resveratrol in cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa
"highlight2" >Dose↝, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >necrosis↑, "highlight2" >ROS↑, "highlight2" >eff↑,
6027- CGA,  CUR,  EGCG,  QC,  RES  Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol
- Review, Nor, NA
"highlight2" >*ROS↓, "highlight2" >ROS↑,
16- CP,  RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
"highlight2" >HH↓, "highlight2" >Gli1↓, "highlight2" >EMT↓, "highlight2" >N-cadherin↓, "highlight2" >E-cadherin↑, "highlight2" >Snail↓, "highlight2" >TumCI↓, "highlight2" >TumMeta↓,
5780- CRMs,  HCAs,  RES,  Sper,  ASA  Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- Review, Var, NA
"highlight2" >*OS↑, "highlight2" >*AntiAge↑, "highlight2" >*cardioP↑, "highlight2" >*neuroP↑, "highlight2" >AntiCan↑, "highlight2" >*TNF-α↓, "highlight2" >*Weight↓, "highlight2" >*BP↓, "highlight2" >*Inflam↓, "highlight2" >*Insulin↓, "highlight2" >*ROS↓, "highlight2" >*AMPK↑, "highlight2" >*mTOR↓, "highlight2" >*SIRT1↑, "highlight2" >CRM↑,
5791- CRMs,  HCA,  NAD,  Sper,  RES  Caloric Restriction Mimetics in Nutrition and Clinical Trials
- Review, Nor, NA
"highlight2" >*Dose↝, "highlight2" >*Glycolysis↓,
4881- CUR,  SFN,  RES,  EGCG,  Lyco  An update of Nrf2 activators and inhibitors in cancer prevention/promotion
- Review, Var, NA
"highlight2" >*NRF2↑, "highlight2" >*antiOx↑,
5397- CUR,  SFN,  RES,  EGCG,  Ash  Targeting Cancer Stem Cells with Phytochemicals: Molecular Mechanisms and Therapeutic Potential
- Review, Var, NA
"highlight2" >CSCs↓,
3862- CUR,  RES,    The metalloproteinase ADAM10: A useful therapeutic target?
- Review, AD, NA
"highlight2" >*SIRT1↑, "highlight2" >*ADAM10↑,
3748- CUR,  RES,  Hup,  Riv,  Gala  Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease
- Review, AD, NA
"highlight2" >*AChE↓, "highlight2" >*Inflam↓, "highlight2" >*Aβ↓, "highlight2" >*cognitive↑, "highlight2" >*ROS↓,
128- CUR,  RES,    Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer
- in-vivo, Pca, NA
"highlight2" >lipid-P↓, "highlight2" >chemoPv↑, "highlight2" >GSH↑, "highlight2" >SOD↑, "highlight2" >GSTs↑, "highlight2" >glucose↓,
134- CUR,  RES,  MEL,  SIL,    Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
"highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >Trx1↓, "highlight2" >TumCG↓, "highlight2" >eff↓, "highlight2" >TXNIP↑,
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
"highlight2" >p38↓, "highlight2" >MKP5↑, "highlight2" >TNF-α↓, "highlight2" >COX2↓, "highlight2" >NF-kB↓,
872- CUR,  RES,    New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
- in-vitro, BC, TUBO - in-vitro, BC, SALTO
"highlight2" >TumCP↓, "highlight2" >tumCV↓, "highlight2" >p62↓, "highlight2" >p62↑, "highlight2" >TumAuto↑, "highlight2" >TumAuto↓, "highlight2" >ROS↑, "highlight2" >ROS↓, "highlight2" >CHOP↑,
1383- CUR,  BBR,  RES,    Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases
- Review, NA, NA
"highlight2" >GSK‐3β↝, "highlight2" >ROS↑,
685- EGCG,  CUR,  SFN,  RES,  GEN  The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
- Analysis, NA, NA
"highlight2" >Bcl-2↓, "highlight2" >survivin↓, "highlight2" >XIAP↓, "highlight2" >EMT↓, "highlight2" >Apoptosis↑, "highlight2" >Nanog↓, "highlight2" >cMyc↓, "highlight2" >OCT4↓, "highlight2" >Snail↓, "highlight2" >Slug↓, "highlight2" >Zeb1↓, "highlight2" >TCF↓,
4664- GEN,  CUR,  RES,  EGCG,  SFN  Targeting cancer stem cells by nutraceuticals for cancer therapy
- Review, Var, NA
"highlight2" >CSCs↓, "highlight2" >other↝, "highlight2" >eff↑, "highlight2" >CD44↓, "highlight2" >p‑STAT3↓,
166- GEN,  EGCG,  RES,  CUR,    Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer
- in-vivo, Pca, NA
"highlight2" >HH↓, "highlight2" >Gli1↓,
1534- LT,  Api,  EGCG,  RES,    Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, PC, Bxpc-3
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >eff↓, "highlight2" >*toxicity↑, "highlight2" >Dose?, "highlight2" >eff↓, "highlight2" >eff↓,
1721- Lyco,  RES,  VitC,    Lycopene, resveratrol, vitamin C and FeSO4 increase damage produced by pro-oxidant carcinogen 4-nitroquinoline-1-oxide in Drosophila melanogaster: Xenobiotic metabolism implications.
- in-vitro, Pca, PC3 - in-vitro, Lung, A549 - in-vitro, Cerv, HeLa - in-vitro, BC, MCF-7 - in-vitro, Liver, HepG2
"highlight2" >ROS↑,
4701- PTS,  RES,    Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene
- Review, Var, NA
"highlight2" >CSCs↓, "highlight2" >E-cadherin↑, "highlight2" >NF-kB↓, "highlight2" >EMT↓, "highlight2" >GRP78/BiP↓, "highlight2" >CD133↓, "highlight2" >COX2↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >NOTCH↓,
4703- PTS,  RES,    Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging - A scoping review
- NA, Nor, NA
"highlight2" >*AntiAge↑, "highlight2" >*eff↑, "highlight2" >*Inflam↓, "highlight2" >*AntiCan↑, "highlight2" >*ROS↓, "highlight2" >*Catalase↑, "highlight2" >*GSR↑, "highlight2" >*HO-1↑, "highlight2" >*NAD↑, "highlight2" >*NQO1↑, "highlight2" >*SOD↑, "highlight2" >*NRF2↑,
67- QC,  RES,    Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
"highlight2" >cJun↑, "highlight2" >AR↓,
873- QC,  RES,  CUR,  PI,    Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal Absorption
- in-vitro, Nor, NA
"highlight2" >*BioEnh↑,
3080- RES,    Resveratrol: A miraculous natural compound for diseases treatment
- Review, Var, NA
"highlight2" >SIRT1↑, "highlight2" >ROCK1↓, "highlight2" >AMPK↑, "highlight2" >*lipid-P↓, "highlight2" >Aβ↓, "highlight2" >COX2↓, "highlight2" >angioG↓, "highlight2" >Hif1a↓, "highlight2" >VEGF↓,
3073- RES,    Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy
- in-vitro, Nor, NA
"highlight2" >*NLRP3↓, "highlight2" >*mtDam↓, "highlight2" >*p38↑,
3074- RES,    Possible therapeutic targets for NLRP3 inflammasome-induced breast cancer
- Review, BC, NA
"highlight2" >NLRP3↓, "highlight2" >SIRT1↑,
3075- RES,  Rad,    The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice
- in-vivo, Nor, NA
"highlight2" >*SIRT1↑, "highlight2" >*radioP↑, "highlight2" >*NLRP3↓, "highlight2" >*Weight↑, "highlight2" >*IL1β↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
"highlight2" >IL6↓, "highlight2" >MMPs↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >BioAv↓, "highlight2" >Half-Life↑, "highlight2" >BioAv↑, "highlight2" >Dose↝, "highlight2" >angioG↓, "highlight2" >IL10↓, "highlight2" >VEGF↓, "highlight2" >NF-kB↓, "highlight2" >COX2↓, "highlight2" >SIRT1↑, "highlight2" >Wnt↓, "highlight2" >cMyc↓, "highlight2" >STAT3↓, "highlight2" >PTEN↑, "highlight2" >ROS↑, "highlight2" >RadioS↑, "highlight2" >Hif1a↓, "highlight2" >E-cadherin↓, "highlight2" >Vim↓, "highlight2" >angioG↓,
3077- RES,    Resveratrol attenuates matrix metalloproteinase-9 and -2-regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways
- in-vitro, Chon, HTB94
"highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >SOX9↑, "highlight2" >MMPs↓, "highlight2" >p‑p38↑, "highlight2" >p‑JNK↓, "highlight2" >NF-kB↓, "highlight2" >HO-1↓,
3078- RES,    The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment
- Review, Pca, NA
"highlight2" >*ROS↓, "highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >Apoptosis↑, "highlight2" >Hif1a↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >Cyt‑c↑, "highlight2" >Dose↝, "highlight2" >MMPs↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >EMT↓, "highlight2" >E-cadherin↑, "highlight2" >N-cadherin↓, "highlight2" >AR↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
"highlight2" >angioG↓, "highlight2" >TumMeta↓, "highlight2" >ChemoSen↑, "highlight2" >NADPH↑, "highlight2" >SIRT1↑, "highlight2" >NF-kB↓, "highlight2" >NLRP3↓, "highlight2" >Dose↝, "highlight2" >COX2↓, "highlight2" >MMP9↓, "highlight2" >PGE2↓, "highlight2" >TIMP1↑, "highlight2" >TIMP2↑, "highlight2" >Sp1/3/4↓, "highlight2" >p‑JNK↓, "highlight2" >uPAR↓, "highlight2" >ROS↓, "highlight2" >CXCR4↓, "highlight2" >IL6↓, "highlight2" >Gli1↓, "highlight2" >*ROS↓, "highlight2" >*GSTs↑, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*GPx↑, "highlight2" >*lipid-P↓, "highlight2" >*GSH↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >eff↑,
3072- RES,    Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
"highlight2" >tumCV↓, "highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >NLRP3↓, "highlight2" >JAK2↓, "highlight2" >STAT3↓, "highlight2" >IL1β↓, "highlight2" >IL18↓, "highlight2" >IL6↓, "highlight2" >TNF-α↓, "highlight2" >Inflam↓,
3081- RES,    Resveratrol and p53: How are they involved in CRC plasticity and apoptosis?
- Review, CRC, NA
"highlight2" >NF-kB↓, "highlight2" >FAK↓, "highlight2" >Ki-67↓, "highlight2" >MMP9↓, "highlight2" >CSCs↓, "highlight2" >CD44↓, "highlight2" >CD133↓, "highlight2" >ALDH1A1↓, "highlight2" >EMT↓, "highlight2" >ChemoSen↑, "highlight2" >Hif1a↓, "highlight2" >ITGB1↓, "highlight2" >Inflam↓,
3082- RES,    Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vivo, NA, NA
"highlight2" >VEGF↓, "highlight2" >CXCL12↓, "highlight2" >IL6↓, "highlight2" >α-SMA↓, "highlight2" >Hif1a↓, "highlight2" >TumCI↓, "highlight2" >EMT↓,
3083- RES,    Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
"highlight2" >YAP/TEAD↓, "highlight2" >Rho↓, "highlight2" >FAK↓, "highlight2" >MMP9↓, "highlight2" >ChemoSen↑, "highlight2" >RAS↓, "highlight2" >ROCK1↓, "highlight2" >TumCI↓, "highlight2" >TumMeta↓,
3084- RES,    Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D
"highlight2" >TumCP↓, "highlight2" >EZH2↓, "highlight2" >p‑ERK↓,
3085- RES,    Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1
- in-vitro, Cerv, NA
"highlight2" >TET1↑, "highlight2" >Wnt↓, "highlight2" >β-catenin/ZEB1↓,
3086- RES,    Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, DU145
"highlight2" >TET1↑, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >TIMP2↑, "highlight2" >TIMP3↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓,
3087- RES,    Resveratrol cytotoxicity is energy-dependent
- Review, Var, NA
"highlight2" >OXPHOS↓, "highlight2" >eff↝, "highlight2" >eff↑,
3088- RES,    Notch signaling mediated repressive effects of resveratrol in inducing caspasedependent apoptosis in MCF-7 breast cancer cells
- in-vitro, BC, MCF-7
"highlight2" >NOTCH1↓, "highlight2" >BAX↑, "highlight2" >CDK4↝, "highlight2" >Casp3↑, "highlight2" >P21↑,
3089- RES,    The Role of Resveratrol in Cancer Therapy
- Review, Var, NA
"highlight2" >angioG↓, "highlight2" >VEGF↓, "highlight2" >EGFR↓, "highlight2" >FGF↑, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >TIMP1↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >NF-kB↓, "highlight2" >Hif1a↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >MAPK↓, "highlight2" >EMT↓, "highlight2" >AR↓,
3071- RES,    Resveratrol and Its Anticancer Effects
- Review, Var, NA
"highlight2" >chemoPv↑, "highlight2" >SIRT1↑, "highlight2" >Hif1a↓, "highlight2" >VEGF↓, "highlight2" >STAT3↓, "highlight2" >NF-kB↓, "highlight2" >COX2↓, "highlight2" >PI3K↓, "highlight2" >mTOR↓, "highlight2" >NRF2↑, "highlight2" >NLRP3↓, "highlight2" >H2O2↑, "highlight2" >ROS↑, "highlight2" >P53↑, "highlight2" >PUMA↑, "highlight2" >BAX↑,
3070- RES,    Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma
- in-vitro, RCC, ACHN - in-vitro, RCC, 786-O - in-vivo, NA, NA
"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Apoptosis↑, "highlight2" >NLRP3↓,
3069- RES,    Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway
- in-vitro, Nor, N9
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*ROS↓, "highlight2" >*NF-kB↓, "highlight2" >*AMPK↑, "highlight2" >*SIRT1↑, "highlight2" >*miR-155↓, "highlight2" >*NLRP3↓,
3068- RES,    Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation
- in-vitro, lymphoma, U937
"highlight2" >p65↓, "highlight2" >SOD2↓, "highlight2" >Prx↓, "highlight2" >Catalase↓, "highlight2" >Trx↓, "highlight2" >TNF-α↓, "highlight2" >IL8↓, "highlight2" >MCP1↓, "highlight2" >SIRT1↑,
3067- RES,    Proteomic Profiling Reveals That Resveratrol Inhibits HSP27 Expression and Sensitizes Breast Cancer Cells to Doxorubicin Therapy
- in-vitro, BC, MCF-7
"highlight2" >Apoptosis↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >HSP27↓,
3066- RES,    Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells
"highlight2" >GSK‐3β↑, "highlight2" >Akt↓, "highlight2" >CHOP↑, "highlight2" >ER Stress↑, "highlight2" >PERK↑, "highlight2" >ATF6↑, "highlight2" >UPR↑, "highlight2" >GlucoseCon↓,
3065- RES,    Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response
- in-vitro, lymphoma, NA
"highlight2" >UPR↑, "highlight2" >IRE1↑, "highlight2" >p‑eIF2α↑, "highlight2" >PERK↑, "highlight2" >ATF6↑, "highlight2" >GRP78/BiP↑, "highlight2" >GRP94↑, "highlight2" >CHOP↑, "highlight2" >GADD34↑, "highlight2" >ATF4↑, "highlight2" >XBP-1↑, "highlight2" >Ca+2↑, "highlight2" >ER Stress↑,
3064- RES,    Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species–Mediated Hypoxia-Inducible Factor-1α Activation
- in-vitro, CRC, HT-29 - in-vitro, BC, T47D - in-vitro, Lung, LLC1
"highlight2" >FDG↓, "highlight2" >ROS↓, "highlight2" >Hif1a↓, "highlight2" >GLUT1↓, "highlight2" >lactateProd↓,

Showing Research Papers: 1 to 50 of 170
Page 1 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 170

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 3,   GPx↑, 1,   GSH↑, 1,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 8,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 2,   Glycolysis↓, 1,   NAD↑, 1,   SIRT1↑, 5,  

Cell Death ⓘ

p38↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,  

Migration ⓘ

miR-155↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   Inflam↓, 5,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   ADAM10↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 3,  

Drug Metabolism & Resistance ⓘ

BioEnh↑, 1,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   radioP↑, 1,   toxicity↑, 1,   Weight↓, 1,   Weight↑, 1,  
Total Targets: 51

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:141  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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