Physalin F & B / Bcl-2 Cancer Research Results

PFB, Physalin F & B: Click to Expand ⟱

Features: Anti-inflammatory, immunomodulatory

From Physalis minima

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱

Source: HalifaxProj (inhibit) CGL-Driver Genes

Type: Antiapoptotic Oncogene

The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.

Scientific Papers found: Click to Expand⟱

34-

PFB,

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription

in-vitro,

PC,

PANC1

HH↓, Gli1↓, GLI2↓, PTCH1↓, Bcl-2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Bcl-2↓, 1,

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1, HH↓, 1, PTCH1↓, 1,

Migration ⓘ

GLI2↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells