Database Query Results : Quercetin, ,

QC, Quercetin: Click to Expand ⟱
Features:
Plant pigment (flavonoid) found in red wine, onions, green tea, apples and berries.
Quercetin is thought to contribute to anticancer effects through several mechanisms:
-Antioxidant Activity:
-Induction of Apoptosis:modify Bax:Bcl-2 ratio
-Anti-inflammatory Effects:
-Cell Cycle Arrest:
-Inhibition of Angiogenesis and Metastasis: (VEGF)

Cellular Pathways:
-PI3K/Akt/mTOR Pathway: central to cell proliferation, survival, and metabolism.
-MAPK/ERK Pathway: influencing cell proliferation, differentiation, and apoptosis.
-NF-κB Pathway: downregulate NF-κB
-JAK/STAT Pathway: interfere with the activation of STAT3
-Apoptotic Pathways: intrinsic (mitochondrial) and extrinsic (death receptor-mediated) pathways

Quercetin has been used at doses around 500–1000 mg per day
Quercetin’s bioavailability from foods or standard supplements can be low.

-Note half-life 11 to 28 hours.
BioAv low 1-10%, poor water-solubility, consuming with fat may improve bioavialability. also piperine or VitC.
Pathways:
- induce ROS production in cancer cells (higher dose). Typicallys Lowers ROS in normal cells(unless it is high dose?)or depends on Redox status?. "quercetin paradox"
- ROS↑ related: MMP↓(ΔΨm), ER Stress↑, UPR↑, GRP78↑, Ca+2↑, Cyt‑c↑, Caspases↑, DNA damage↑, cl-PARP↑, HSP↓, Prx,
- Confusing info about Lowering AntiOxidant defense in Cancer Cells: NRF2↓(some contrary), TrxR↓**, SOD↓(contrary), GSH↓ Catalase↓(contrary), HO1↓(some contrary), GPx↓(some contrary)
- Raises AntiOxidant defense in Normal Cells: ROS↓, NRF2↑, SOD↑, GSH↑, Catalase↑,
- lowers Inflammation : NF-kB↓, COX2↓, p38↓, Pro-Inflammatory Cytokines : NLRP3↓, IL-1β↓, TNF-α↓, IL-6↓, IL-8↓
- inhibit Growth/Metastases : TumMeta↓, TumCG↓, EMT↓, MMPs↓, MMP2↓, MMP9↓, TIMP2, IGF-1↓, uPA↓, VEGF↓, ROCK1↓, FAK↓, NF-κB↓, CXCR4↓, SDF1↓, TGF-β↓, α-SMA↓, ERK↓
- reactivate genes thereby inhibiting cancer cell growth : HDAC↓, DNMTs↓, EZH2↓, P53↑, HSP↓, Sp proteins↓, TET↑
- cause Cell cycle arrest : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓,
- inhibits Migration/Invasion : TumCMig↓, TumCI↓, TNF-α↓, FAK↓, ERK↓, EMT↓, TOP1↓, TET1,
- inhibits glycolysis and ATP depletion : HIF-1α↓, PKM2↓, cMyc↓, GLUT1↓, LDH↓, LDHA↓, HK2↓, PFKs↓, PDKs↓, ECAR↓, OXPHOS↓, GRP78↑, GlucoseCon↓
- inhibits angiogenesis↓ : VEGF↓, HIF-1α↓, Notch↓, FGF↓, PDGF↓, EGFR↓,
- some indication of inhibiting Cancer Stem Cells : CSC↓, CK2↓, Hh↓, CD24↓, β-catenin↓, Notch2↓,
- Others: PI3K↓, AKT↓, JAK↓, STAT↓, Wnt↓, β-catenin↓, AMPK, α↓, ERK↓, JNK, - SREBP (related to cholesterol).
- Synergies: chemo-sensitization, chemoProtective, RadioSensitizer, RadioProtective, Others(review target notes), Neuroprotective, Cognitive, Renoprotection, Hepatoprotective, CardioProtective,

- Selectivity: Cancer Cells vs Normal Cells

Rank Pathway / Axis Cancer Cells Normal Cells Label Primary Interpretation Notes
1 Reactive oxygen species (ROS) ↑ ROS (dose-, metal-, context-dependent) ↓ ROS Conditional Driver Biphasic redox modulation Quercetin exhibits pro-oxidant behavior in cancer cells while protecting normal cells
2 Mitochondrial integrity / intrinsic apoptosis ↓ ΔΨm; ↑ caspase activation ↔ preserved Driver Execution of intrinsic apoptosis Mitochondrial dysfunction is a central apoptosis route in cancer cells
3 PI3K → AKT → mTOR axis ↓ AKT / ↓ mTOR ↔ adaptive suppression Driver Growth and survival inhibition AKT/mTOR suppression is a consistently reported upstream effect in cancer models
4 NF-κB signaling ↓ NF-κB activation ↓ inflammatory NF-κB tone Secondary Reduced survival and inflammatory transcription NF-κB inhibition contributes to chemosensitization and apoptosis susceptibility
5 MAPK signaling (JNK / p38) ↑ JNK / ↑ p38 ↔ minimal Secondary Stress-mediated apoptosis signaling MAPK activation supports apoptosis downstream of redox stress
6 Cell cycle regulation ↑ G1/S or G2/M arrest ↔ largely spared Phenotypic Cytostatic growth control Cell-cycle arrest reflects disruption of growth signaling
7 HIF-1α hypoxia signaling ↓ HIF-1α ↔ minimal Secondary Reduced hypoxia tolerance Quercetin interferes with hypoxia-driven transcriptional programs
8 NRF2 antioxidant response ↑ NRF2 (adaptive, context-dependent) ↑ NRF2 (protective) Adaptive Stress compensation NRF2 induction reflects redox buffering rather than primary cytotoxicity


Scientific Papers found: Click to Expand⟱
380- AgNPs,  QC,  CA,  Chit,    Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
- in-vitro, MG, U118MG
"highlight2" >TumCG↓,
6- Ba,  Api,  QC,    Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer
- in-vitro, Pca, PC3
"highlight2" >HH↓, "highlight2" >Gli1↓,
3633- BBR,  LT,  Cro,  QC,    Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy
- Review, AD, NA
"highlight2" >*AChE↓, "highlight2" >*AChE↓,
24- EGCG,  GEN,  QC,    Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin
- in-vitro, Pca, 22Rv1
"highlight2" >NQO1↑, "highlight2" >P53↑, "highlight2" >NQO2↑, "highlight2" >chemoPv↑, "highlight2" >TumCP↓, "highlight2" >AR↓,
25- EGCG,  QC,    Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
"highlight2" >COMT↓, "highlight2" >TumCP↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
"highlight2" >BAD↓, "highlight2" >cl‑PARP↑, "highlight2" >Casp7↑, "highlight2" >IκB↓, "highlight2" >Ki-67↓, "highlight2" >VEGF↓, "highlight2" >EGFR↓, "highlight2" >FGF↓, "highlight2" >TGF-β↓, "highlight2" >TNF-α↓, "highlight2" >SCF↓, "highlight2" >Bax:Bcl2↑, "highlight2" >NF-kB↓, "highlight2" >chemoP↑, "highlight2" >ChemoSen↑, "highlight2" >TumVol↓,
2458- EGCG,  QC,    Identification of plant-based hexokinase 2 inhibitors: combined molecular docking and dynamics simulation studies
- Analysis, Nor, NA
"highlight2" >HK2↓,
2642- Flav,  QC,  Api,  KaempF,  MCT  In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type
- in-vitro, Nor, NA - in-vivo, Nor, NA
"highlight2" >*BioAv↑, "highlight2" >*eff↝, "highlight2" >BioEnh↑,
4687- LT,  QC,    Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells
- in-vitro, Pca, DU145
"highlight2" >CSCs↓, "highlight2" >EMT↓, "highlight2" >MMPs↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓,
1997- Myr,  QC,    Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity
- in-vitro, Lung, A549
"highlight2" >TrxR↓, "highlight2" >eff↑, "highlight2" >TumCCA↑, "highlight2" >eff↓, "highlight2" >ROS↑,
981- NarG,  QC,    Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer
- in-vivo, NA, NA
"highlight2" >TumVol↓, "highlight2" >CYP19↓,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
"highlight2" >tumCV↓, "highlight2" >Apoptosis↑, "highlight2" >PI3k/Akt/mTOR↓, "highlight2" >Wnt/(β-catenin)↓, "highlight2" >MAPK↝, "highlight2" >ERK↝, "highlight2" >TumCCA↑, "highlight2" >H2O2↑, "highlight2" >ROS↑, "highlight2" >TumAuto↑, "highlight2" >MMPs↓, "highlight2" >P53↑, "highlight2" >Casp3↑, "highlight2" >Hif1a↓, "highlight2" >cFLIP↓, "highlight2" >IL6↓, "highlight2" >IL10↓, "highlight2" >lactateProd↓, "highlight2" >Glycolysis↓, "highlight2" >PKM2↓, "highlight2" >GLUT1↓, "highlight2" >COX2↓, "highlight2" >VEGF↓, "highlight2" >OCR↓, "highlight2" >ECAR↓, "highlight2" >STAT3↓, "highlight2" >MMP2↓, "highlight2" >MMP9:TIMP1↓, "highlight2" >mTOR↓,
911- QC,  SFN,    Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial
"highlight2" >TumCG↓, "highlight2" >Risk↓,
909- QC,    Exploring the therapeutic potential of quercetin in cancer treatment: Targeting long non-coding RNAs
- Review, NA, NA
"highlight2" >other↓, "highlight2" >other↑,
908- QC,    Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update
- Review, NA, NA
"highlight2" >AntiCan↑, "highlight2" >ROS↑,
907- QC,    A Comprehensive Study on the Anti-cancer Effects of Quercetin and Its Epigenetic Modifications in Arresting Progression of Colon Cancer Cell Proliferation
- Review, NA, NA
"highlight2" >AntiCan↑,
906- QC,    The interplay between reactive oxygen species and antioxidants in cancer progression and therapy: a narrative review
- Review, NA, NA
"highlight2" >ROS↑,
905- QC,    Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation. Quercetin as an effective antioxidant against pro-oxidant effects of urate
- Analysis, NA, NA
"highlight2" >ROS↑,
904- QC,    Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase
- Analysis, NA, NA
"highlight2" >ROS↑, "highlight2" >H2O2↑,
903- QC,    Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow
- in-vivo, NA, NA
"highlight2" >ROS⇅,
902- QC,    Prooxidant activities of quercetin, p-courmaric acid and their derivatives analysed by quantitative structure–activity relationship
- Analysis, NA, NA
"highlight2" >ROS↑,
901- QC,    Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2
- Analysis, Var, NA
"highlight2" >ROS↑,
900- QC,    Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
- in-vivo, Nor, NA
"highlight2" >*Weight↓, "highlight2" >*TAC∅, "highlight2" >*ROS↑,
99- QC,    Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1
- in-vitro, Pca, PC3
"highlight2" >EMT↓, "highlight2" >E-cadherin↑, "highlight2" >N-cadherin↓, "highlight2" >Ki-67↓, "highlight2" >PI3K/Akt↓, "highlight2" >MALAT1↓, "highlight2" >TumCG↓,
912- QC,  2DG,    Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities
"highlight2" >Apoptosis↑, "highlight2" >ROS↓, "highlight2" >GSH∅, "highlight2" >other↑,
899- QC,    Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites
- in-vivo, Var, NA
"highlight2" >ROS↑, "highlight2" >GSH↓,
898- QC,    Anti- and pro-oxidant activity of rutin and quercetin derivatives
- Analysis, Var, NA
"highlight2" >ROS↑,
897- QC,    Anti- and prooxidant effects of chronic quercetin administration in rats
- in-vivo, Nor, NA
"highlight2" >*MDA↓, "highlight2" >*GSH⇅, "highlight2" >*ROS⇅,
896- QC,    Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin: Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA
- in-vivo, Var, NA
"highlight2" >ROS↑,
895- QC,    Theoretical Study of the Antioxidant Activity of Quercetin Oxidation Products
- Analysis, Var, NA
"highlight2" >ROS⇅,
894- QC,    The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis
- in-vitro, Nor, NA
"highlight2" >Apoptosis↑, "highlight2" >*NF-kB↓, "highlight2" >*AP-1↓, "highlight2" >*P53↝, "highlight2" >*ROS↓,
893- QC,    Quercetin: Prooxidant Effect and Apoptosis in Cancer
- Analysis, Var, NA
"highlight2" >ROS↑,
892- QC,    Antioxidant vs. pro-oxidant activities of quercetin in aqueous phase: A Density Functional Theory study
- Analysis, Var, NA
"highlight2" >ROS↑,
891- QC,    Chapter 9 - Quercetin: Prooxidant Effect and Apoptosis in Cancer
- in-vitro, Var, NA
"highlight2" >ROS↑, "highlight2" >AntiTum↑,
890- QC,    PROOXIDANT ACTIVITIES OF ANTIOXIDANTS AND THEIR IMPACT ON HEALTH
- Review, Var, NA
"highlight2" >ROS↑,
889- QC,    The multifaceted role of quercetin derived from its mitochondrial mechanism
- vitro+vivo, Var, NA
"highlight2" >MMP↓, "highlight2" >ATP↝, "highlight2" >OXPHOS↝, "highlight2" >ROS↑,
873- QC,  RES,  CUR,  PI,    Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal Absorption
- in-vitro, Nor, NA
"highlight2" >*BioEnh↑,
138- QC,  CUR,    Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >DNMTs↓, "highlight2" >AR↑, "highlight2" >MMP↓,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
"highlight2" >cycD1/CCND1↓, "highlight2" >cycE/CCNE↓, "highlight2" >CDK2↓, "highlight2" >CDK4/6↓, "highlight2" >E2Fs↓, "highlight2" >PCNA↓, "highlight2" >cDC2↓, "highlight2" >PTEN↑, "highlight2" >MSH2↑, "highlight2" >P21↑, "highlight2" >EP300↑, "highlight2" >BRCA1↑, "highlight2" >NF2↑, "highlight2" >TSC1↑, "highlight2" >TGFβR1↑, "highlight2" >P53↑, "highlight2" >RB1↑, "highlight2" >AKT1↓, "highlight2" >cMyc↓, "highlight2" >CDC7↓, "highlight2" >cycF↓, "highlight2" >CDC16↓, "highlight2" >CUL4B↑, "highlight2" >CBP↑, "highlight2" >TSC2↑, "highlight2" >HER2/EBBR2↓, "highlight2" >BCR↓, "highlight2" >TumCCA↑, "highlight2" >chemoPv↑,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
"highlight2" >*antiOx↑, "highlight2" >*GSH↑, "highlight2" >*ROS↓, "highlight2" >*Dose↑, "highlight2" >*NADPH↓, "highlight2" >*AMP↓, "highlight2" >*NF-kB↓, "highlight2" >*p38↑, "highlight2" >*MAPK↑, "highlight2" >*SOD↑, "highlight2" >*MDA↓, "highlight2" >*iNOS↓, "highlight2" >*Catalase↑, "highlight2" >*PI3K↑, "highlight2" >*Akt↑, "highlight2" >*lipid-P↓, "highlight2" >*memory↑, "highlight2" >*radioP↑, "highlight2" >*neuroP↑, "highlight2" >*MDA↓,
1493- QC,    New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer
- NA, Bladder, NA
"highlight2" >RadioS↑, "highlight2" >ChemoSen↑,
3337- QC,    Endoplasmic Reticulum Stress-Relieving Effect of Quercetin in Thapsigargin-Treated Hepatocytes
- in-vitro, NA, HepG2
"highlight2" >*Inflam↓, "highlight2" >*UPR↓, "highlight2" >*GRP58↓, "highlight2" >*XBP-1↓, "highlight2" >*ER Stress↓, "highlight2" >*antiOx↑, "highlight2" >TNF-α↓, "highlight2" >p‑eIF2α↓, "highlight2" >p‑IRE1↓, "highlight2" >p‑JNK↓, "highlight2" >CHOP↓,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
"highlight2" >*neuroP↑, "highlight2" >*lipid-P↓, "highlight2" >*antiOx↑, "highlight2" >*Aβ↓, "highlight2" >*Inflam↓, "highlight2" >*BBB↝, "highlight2" >*NF-kB↓, "highlight2" >*iNOS↓, "highlight2" >*memory↑, "highlight2" >*cognitive↑, "highlight2" >*AChE↓, "highlight2" >*MMP↑, "highlight2" >*ROS↓, "highlight2" >*ATP↑, "highlight2" >*AMPK↑, "highlight2" >*NADPH↓, "highlight2" >*p‑tau↓,
3335- QC,    Recent advances on the improvement of quercetin bioavailability
- Review, NA, NA
"highlight2" >*BioAv↓,
3334- QC,    Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans
- Trial, Nor, NA
"highlight2" >*Half-Life↑,
2431- QC,    The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells
- in-vitro, Nor, TM4
"highlight2" >*Apoptosis↓, "highlight2" >*ROS↓, "highlight2" >*antiOx↓, "highlight2" >*MMP↑, "highlight2" >*GPI↑, "highlight2" >*HK2↑, "highlight2" >*ALDOA↑, "highlight2" >*PKM1↑, "highlight2" >*LDHA↑, "highlight2" >*PFKL↑,
2344- QC,    Quercetin: A natural solution with the potential to combat liver fibrosis
- Review, Nor, NA
"highlight2" >*HK2↓, "highlight2" >*PFKP↓, "highlight2" >*PKM2↓, "highlight2" >*hepatoP↑, "highlight2" >*ALAT↓, "highlight2" >*AST↓, "highlight2" >*Glycolysis↓, "highlight2" >*lactateProd↓, "highlight2" >*GlucoseCon↓, "highlight2" >*CXCL1↓, "highlight2" >*Inflam↓,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
"highlight2" >*ROS↓, "highlight2" >*GSH↑, "highlight2" >*Catalase↑, "highlight2" >*SOD↑, "highlight2" >*MDA↓, "highlight2" >*GPx↑, "highlight2" >*Copper↓, "highlight2" >*Iron↓, "highlight2" >Apoptosis↓, "highlight2" >TumCCA↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >PKM2↓, "highlight2" >GLUT1↓, "highlight2" >LDHA↓, "highlight2" >ROS↑,
2342- QC,    Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway
- in-vitro, HCC, Bel-7402 - in-vitro, HCC, SMMC-7721 cell - in-vivo, NA, NA
"highlight2" >TumCP↓, "highlight2" >HK2↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >Glycolysis↓,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
"highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >VEGF↓, "highlight2" >Glycolysis↓, "highlight2" >lactateProd↓, "highlight2" >PKM2↓, "highlight2" >GLUT1↓, "highlight2" >LDHA↓, "highlight2" >TumAuto↑, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >TumMeta↓, "highlight2" >MMP3↓, "highlight2" >eff↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >TumAuto↑, "highlight2" >LC3B-II↑,
2340- QC,    Oral Squamous Cell Carcinoma Cells with Acquired Resistance to Erlotinib Are Sensitive to Anti-Cancer Effect of Quercetin via Pyruvate Kinase M2 (PKM2)
- in-vitro, OS, NA
"highlight2" >TumCG↓, "highlight2" >GlucoseCon↓, "highlight2" >TumCI↓, "highlight2" >GLUT1↓, "highlight2" >PKM2↓, "highlight2" >LDHA↓, "highlight2" >Glycolysis↓, "highlight2" >lactateProd↓, "highlight2" >HK2↓, "highlight2" >eff↑,
2339- QC,    Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
- in-vivo, Nor, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*NLRP3↓, "highlight2" >*Sepsis↓, "highlight2" >*PKM2↓, "highlight2" >*SIRT1↓,
2338- QC,    Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury
- Review, Nor, NA
"highlight2" >*SIRT1↑, "highlight2" >*NLRP3↓, "highlight2" >*Inflam↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*IL6↓, "highlight2" >*PKM2↓, "highlight2" >*HO-1↑, "highlight2" >*ROS↓, "highlight2" >*NO↓, "highlight2" >*MDA↓, "highlight2" >*antiOx↑, "highlight2" >*COX2↓, "highlight2" >*HMGB1↓, "highlight2" >*iNOS↓, "highlight2" >*NF-kB↓,
2303- QC,  doxoR,    Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells
- in-vitro, BC, 4T1 - in-vivo, NA, NA
"highlight2" >cardioP↑, "highlight2" >hepatoP↑, "highlight2" >TumCG↓, "highlight2" >OS↑, "highlight2" >ChemoSen↑, "highlight2" >chemoP↑, "highlight2" >Hif1a↓, "highlight2" >*Hif1a↑, "highlight2" >selectivity↑, "highlight2" >TumVol↓, "highlight2" >OS↑,
2300- QC,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
"highlight2" >AntiTum↑, "highlight2" >Hif1a↓, "highlight2" >*Hif1a↑, "highlight2" >Glycolysis↓, "highlight2" >HK2↓, "highlight2" >PDK3↓, "highlight2" >PFKP?,
913- QC,    Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-435
"highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >DNAdam↑, "highlight2" >Chk2↑, "highlight2" >CycB/CCNB1↓, "highlight2" >CDK1↓, "highlight2" >tumCV↓, "highlight2" >p‑RB1↓, "highlight2" >P21↑,
1201- QC,    Quercetin: a silent retarder of fatty acid oxidation in breast cancer metastasis through steering of mitochondrial CPT1
- in-vivo, BC, NA
"highlight2" >mitResp↓, "highlight2" >Glycolysis↓, "highlight2" >ATP↓, "highlight2" >ROS↑, "highlight2" >GSH↓, "highlight2" >TumMeta↓, "highlight2" >Apoptosis↑, "highlight2" >FAO↓,
980- QC,    Dietary Quercetin Exacerbates the Development of Estrogen-Induced Breast Tumors in Female ACI Rats
- in-vivo, BC, NA
"highlight2" >COMT↓, "highlight2" >ROS∅,
926- QC,  PacT,  doxoR,  Tam,    Bioenhancers from mother nature and their applicability in modern medicine
- Review, Nor, NA
"highlight2" >*BioEnh↑, "highlight2" >BioEnh↑, "highlight2" >BioEnh↑, "highlight2" >BioEnh↑, "highlight2" >BioEnh↑, "highlight2" >BioEnh↑, "highlight2" >BioEnh↑, "highlight2" >P-gp↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
"highlight2" >ROS↑, "highlight2" >GSH↓, "highlight2" >Ca+2↝, "highlight2" >MMP↓, "highlight2" >Casp3↑, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >other↓, "highlight2" >*ROS↓, "highlight2" >*NRF2↑, "highlight2" >HO-1↑, "highlight2" >TumCCA↑, "highlight2" >Inflam↓, "highlight2" >STAT3↓, "highlight2" >DR5↑, "highlight2" >P450↓, "highlight2" >MMPs↓, "highlight2" >IFN-γ↓, "highlight2" >IL6↓, "highlight2" >COX2↓, "highlight2" >IL8↓, "highlight2" >iNOS↓, "highlight2" >TNF-α↓, "highlight2" >cl‑PARP↑, "highlight2" >Apoptosis↑, "highlight2" >P53↑, "highlight2" >Sp1/3/4↓, "highlight2" >survivin↓, "highlight2" >TRAILR↑, "highlight2" >Casp10↑, "highlight2" >DFF45↑, "highlight2" >TNFR 1↑, "highlight2" >Fas↑, "highlight2" >NF-kB↓, "highlight2" >IKKα↓, "highlight2" >cycD1/CCND1↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >E-cadherin↓, "highlight2" >Vim↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >cMyc↓, "highlight2" >EMT↓, "highlight2" >MMP2↓, "highlight2" >NOTCH1↓, "highlight2" >MMP7↓, "highlight2" >angioG↓, "highlight2" >TSP-1↑, "highlight2" >CSCs↓, "highlight2" >XIAP↓, "highlight2" >Snail↓, "highlight2" >Slug↓, "highlight2" >LEF1↓, "highlight2" >P-gp↓, "highlight2" >EGFR↓, "highlight2" >GSK‐3β↓, "highlight2" >mTOR↓, "highlight2" >RAGE↓, "highlight2" >HSP27↓, "highlight2" >VEGF↓, "highlight2" >TGF-β↓, "highlight2" >COL1↓, "highlight2" >COL3A1↓,
922- QC,    Quercetin and ovarian cancer: An evaluation based on a systematic review
- Review, NA, NA
"highlight2" >ROS↑,
921- QC,    Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetin
- in-vitro, lymphoma, U937
"highlight2" >ROS↑, "highlight2" >GSH↓,
920- QC,    Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin
- Review, NA, NA
"highlight2" >GSH↓, "highlight2" >ROS↑,
919- QC,    Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells
- in-vitro, CRC, HCT116
"highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >SESN2↑, "highlight2" >P53↑, "highlight2" >AMPKα↑, "highlight2" >mTOR↓,
918- QC,  CUR,  VitC,    Anti- and pro-oxidant effects of oxidized quercetin, curcumin or curcumin-related compounds with thiols or ascorbate as measured by the induction period method
- Analysis, NA, NA
"highlight2" >ROS↑, "highlight2" >ROS↑,
917- QC,  BML,  Pap,    Quercetin: A Versatile Flavonoid
- Review, Nor, NA
"highlight2" >*BioEnh↑,
916- QC,    Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
- Review, Ovarian, NA
"highlight2" >COX2↓, "highlight2" >CRP↓, "highlight2" >ER Stress↑, "highlight2" >Apoptosis↑, "highlight2" >GRP78/BiP↑, "highlight2" >CHOP↑, "highlight2" >p‑STAT3↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >cMyc↓, "highlight2" >cycD1/CCND1↓, "highlight2" >cFLIP↓, "highlight2" >IL6↓, "highlight2" >IL10↓,
915- QC,    Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management
- Review, NA, NA
"highlight2" >ROS↑,
914- QC,    Quercetin and Cancer Chemoprevention
- Review, NA, NA
"highlight2" >GSH↓, "highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >Ca+2↑, "highlight2" >MMP↓, "highlight2" >Casp3↑, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >β-catenin/ZEB1↓, "highlight2" >AMPKα↑, "highlight2" >ASK1↑, "highlight2" >p38↑, "highlight2" >TRAIL↑, "highlight2" >DR5↑, "highlight2" >cFLIP↓, "highlight2" >Apoptosis↑,
60- QC,  EGCG,  isoFl,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, pCSCs
"highlight2" >Casp3↑, "highlight2" >Casp7↑, "highlight2" >Bcl-2↓, "highlight2" >survivin↓, "highlight2" >XIAP↓, "highlight2" >EMT↓, "highlight2" >Slug↓, "highlight2" >Snail↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >LEF1↓, "highlight2" >CSCs↓, "highlight2" >Apoptosis↑, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >CD44↓, "highlight2" >CD133↓,
52- QC,    Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines
- in-vitro, BC, MCF-7 - in-vitro, Ovarian, SKOV3 - in-vitro, OS, U2OS
"highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >PI3K/Akt↓, "highlight2" >cycD1/CCND1↓, "highlight2" >TumCCA↑,
53- QC,    Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer
- in-vitro, BC, MDA-MB-231 - NA, NA, MDA-MB-468
"highlight2" >E-cadherin↑, "highlight2" >Vim↓, "highlight2" >cycD1/CCND1↓, "highlight2" >cMyc↓, "highlight2" >EMT↓, "highlight2" >TumCG↓, "highlight2" >TumCMig↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >ChemoSen↑,
54- QC,    Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways
- in-vitro, BC, MCF-7
"highlight2" >EMT↓, "highlight2" >E-cadherin↑, "highlight2" >Vim↓, "highlight2" >MMP2↓, "highlight2" >NOTCH1↓, "highlight2" >PI3K/Akt↓, "highlight2" >PI3k/Akt/mTOR↓, "highlight2" >p‑Akt↓, "highlight2" >EZH2↓, "highlight2" >H3K27ac↓, "highlight2" >TumCCA↑, "highlight2" >CSCs↓, "highlight2" >CDK1↓, "highlight2" >CycB/CCNB1↓, "highlight2" >Bcl-xL↓, "highlight2" >Bcl-2↓, "highlight2" >Nanog↓, "highlight2" >H3↓,
55- QC,    Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling
- in-vitro, GC, GCSCs
"highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Cyt‑c↑, "highlight2" >MMP↓, "highlight2" >PI3K/Akt↓, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >TumCG↓, "highlight2" >Apoptosis↑, "highlight2" >CSCs↓,
56- QC,    Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988
"highlight2" >EMT↓, "highlight2" >MMPs↓, "highlight2" >MMP2↓, "highlight2" >MMP7↓, "highlight2" >STAT3↓, "highlight2" >TumCI↓, "highlight2" >TumMeta↓, "highlight2" >tumCV↓,
57- QC,    Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo
- vitro+vivo, PC, PC3
"highlight2" >TSP-1↑, "highlight2" >angioG↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓,
58- QC,  doxoR,    Quercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin
- in-vitro, CRC, HT-29 - in-vitro, NA, CD133+
"highlight2" >Bcl-2↓, "highlight2" >TumCCA↑, "highlight2" >CD133↓, "highlight2" >CSCs↓, "highlight2" >ChemoSen↑, "highlight2" >CycB/CCNB1↑, "highlight2" >cycE/CCNE↓, "highlight2" >cycD1/CCND1↓, "highlight2" >E2Fs↓,
59- QC,    Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)
- in-vitro, BC, MDA-MB-231
"highlight2" >ALDH1A1↓, "highlight2" >CXCR4↓, "highlight2" >MUC1↓, "highlight2" >EpCAM↓, "highlight2" >CSCs↓, "highlight2" >TumCP↓, "highlight2" >TumCI↓, "highlight2" >CD44↓, "highlight2" >CD24↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑,
51- QC,    Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines
- in-vitro, Ovarian, SKOV3
"highlight2" >cycD1/CCND1↓, "highlight2" >TumCCA↑,
61- QC,    Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, ARPE-19
"highlight2" >p‑PI3K↓, "highlight2" >p‑Akt↓, "highlight2" >p‑ERK↓, "highlight2" >NF-kB↓, "highlight2" >p38↓, "highlight2" >ABCG2↓, "highlight2" >CD44↓, "highlight2" >CD133↓, "highlight2" >CSCs↓,
62- QC,  GoldNP,    Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231)
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
"highlight2" >EGFR↓, "highlight2" >PI3k/Akt/mTOR↓, "highlight2" >GSK‐3β↓, "highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >tumCV↓, "highlight2" >mTOR↓, "highlight2" >PTEN↑,
63- QC,    Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
- in-vitro, Pca, NA
"highlight2" >RAGE↓, "highlight2" >PI3K↓, "highlight2" >mTOR↓, "highlight2" >Akt↓, "highlight2" >Apoptosis↑, "highlight2" >TumAuto↑, "highlight2" >ChemoSen↑,
64- QC,    Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW-620 - in-vitro, Colon, Caco-2
"highlight2" >Cyt‑c↑, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >DR4↑, "highlight2" >DR5↑,
65- QC,    Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB
- in-vitro, BC, NA
"highlight2" >HSP27↓, "highlight2" >EMT↓, "highlight2" >NF-kB↓, "highlight2" >Snail↓, "highlight2" >Vim↓, "highlight2" >E-cadherin↑, "highlight2" >CSCs↓,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
"highlight2" >CycB/CCNB1↓, "highlight2" >CDK1↓, "highlight2" >EMT↓, "highlight2" >PI3K↓, "highlight2" >MAPK↓, "highlight2" >Wnt/(β-catenin)↓, "highlight2" >PSA↓, "highlight2" >VEGF↓, "highlight2" >PARP↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >DR5↑, "highlight2" >ROS⇅, "highlight2" >Shh↓, "highlight2" >P53↑, "highlight2" >P21↑, "highlight2" >EGFR↓, "highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >miR-21↓, "highlight2" >TumCP↓, "highlight2" >selectivity↑, "highlight2" >PDGF↓, "highlight2" >EGF↓, "highlight2" >TNF-α↓, "highlight2" >VEGFR2↓, "highlight2" >mTOR↓, "highlight2" >cMyc↓, "highlight2" >MMPs↓, "highlight2" >GRP78/BiP↑, "highlight2" >CHOP↑,
67- QC,  RES,    Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
"highlight2" >cJun↑, "highlight2" >AR↓,
98- QC,    Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
- in-vivo, Stroke, NA
"highlight2" >*Bcl-2↑, "highlight2" >*BAX↓, "highlight2" >*Bax:Bcl2↓, "highlight2" >*cardioP↑, "highlight2" >*Akt↑, "highlight2" >*PI3K↑, "highlight2" >*LDH↓,
43- QC,    Investigation of the anti-cancer effect of quercetin on HepG2 cells in vivo
- in-vivo, Liver, HepG3
"highlight2" >cycD1/CCND1↓, "highlight2" >TumCG↓, "highlight2" >TumCP↓,
35- QC,    Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product
- Study, NA, NA
"highlight2" >ROS↑, "highlight2" >GSH↓,
36- QC,    Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression-independent manner in HPV-positive human cervical cancer-derived cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa
"highlight2" >P53↑, "highlight2" >P21↑, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >Casp7↑, "highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑,
37- QC,    Low Concentrations of Flavonoids Are Protective in Rat H4IIE Cells Whereas High Concentrations Cause DNA Damage and Apoptosis
- in-vivo, Hepat, H4IIE
"highlight2" >DNAdamC↑, "highlight2" >Casp1↑, "highlight2" >BioAv↝,
38- QC,    Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >ROS⇅, "highlight2" >GSH↓, "highlight2" >PI3K/Akt⇅,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
"highlight2" >ROS↑, "highlight2" >GSH↓, "highlight2" >IL6↓, "highlight2" >COX2↓, "highlight2" >IL8↓, "highlight2" >iNOS↓, "highlight2" >TNF-α↓, "highlight2" >MAPK↑, "highlight2" >ERK↑, "highlight2" >SOD↑, "highlight2" >ATP↓, "highlight2" >Casp↑, "highlight2" >PI3K/Akt↓, "highlight2" >mTOR↓, "highlight2" >NOTCH1↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >IFN-γ↓, "highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >Akt↓, "highlight2" >P70S6K↓, "highlight2" >*Keap1↓, "highlight2" >*GPx↑, "highlight2" >*Catalase↑, "highlight2" >*HO-1↑, "highlight2" >*NRF2↑, "highlight2" >NRF2↑, "highlight2" >eff↑, "highlight2" >HIF-1↓,
40- QC,    Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells
- in-vitro, lymphoma, U937
"highlight2" >cycD1/CCND1↓, "highlight2" >cycE/CCNE↓, "highlight2" >E2Fs↓, "highlight2" >CycB/CCNB1↑, "highlight2" >Casp↑, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >TumCP↓,
41- QC,    Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft
- vitro+vivo, AML, HL-60
"highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >Casp3↑, "highlight2" >ROS↑, "highlight2" >ERK↑, "highlight2" >cl‑PARP↑, "highlight2" >MMP↓, "highlight2" >eff↓,
42- QC,    Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells
- in-vitro, AML, HL-60
"highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >COX2↓,
68- QC,  BaP,    Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, PrEC
"highlight2" >PrxI∅, "highlight2" >PrxII∅, "highlight2" >*toxicity↓, "highlight2" >ROS↓, "highlight2" >ROS↑, "highlight2" >ROS∅, "highlight2" >chemoP↑, "highlight2" >PrxII↑, "highlight2" >i-H2O2↓,
44- QC,    Preclinical Colorectal Cancer Chemopreventive Efficacy and p53-Modulating Activity of 3′,4′,5′-Trimethoxyflavonol, a Quercetin Analog
- in-vivo, CRC, HCT116
"highlight2" >P53↑, "highlight2" >chemoPv↑, "highlight2" >TumVol↓, "highlight2" >TumCP↓, "highlight2" >Apoptosis↑,
45- QC,    Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1 and Survivin Expression through Wnt/β-Catenin Signaling Pathway
- in-vitro, Colon, CX-1 - in-vitro, Colon, SW480 - in-vitro, Colon, HT-29 - in-vitro, Colon, HCT116
"highlight2" >cycD1/CCND1↓, "highlight2" >survivin↓, "highlight2" >Wnt/(β-catenin)↓, "highlight2" >tumCV↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑,
46- QC,    Quercetin, but Not Its Glycosidated Conjugate Rutin, Inhibits Azoxymethane-Induced Colorectal Carcinogenesis in F344 Rats
- in-vitro, Colon, F344
"highlight2" >β-catenin/ZEB1↓, "highlight2" >BioAv↓,
47- QC,    Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells
- in-vitro, NSCLC, H460 - in-vitro, NSCLC, A549
"highlight2" >TRAIL↑, "highlight2" >DR5↑, "highlight2" >survivin↓,
48- QC,    Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells
- in-vitro, NSCLC, H460
"highlight2" >TRAILR↑, "highlight2" >Casp10↑, "highlight2" >DFF45↑, "highlight2" >TNFR 1↑, "highlight2" >Fas↑, "highlight2" >NF-kB↓, "highlight2" >IKKα↓,
49- QC,    Plasma rich in quercetin metabolites induces G2/M arrest by upregulating PPAR-γ expression in human A549 lung cancer cells
- in-vitro, Lung, A549
"highlight2" >CDK1↓, "highlight2" >CycB/CCNB1↓, "highlight2" >PPARγ↑,
50- QC,    Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer
- vitro+vivo, Ovarian, A2780S
"highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >Mcl-1↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >angioG↓, "highlight2" >TumCG↓, "highlight2" >Apoptosis↑, "highlight2" >p‑p44↓, "highlight2" >Akt↓, "highlight2" >TumCP↓, "highlight2" >eff↑,
86- QC,  PacT,    Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3)
- vitro+vivo, Pca, PC3
"highlight2" >BAD↑, "highlight2" >IGFBP3↑, "highlight2" >Cyt‑c↑, "highlight2" >cl‑Casp9↑, "highlight2" >Casp10↑, "highlight2" >cl‑PARP↑, "highlight2" >Casp3↑, "highlight2" >IGF-1R↓, "highlight2" >PI3K↓, "highlight2" >p‑Akt↓, "highlight2" >cycD1/CCND1↓, "highlight2" >IGF-1↓, "highlight2" >IGF-2↓, "highlight2" >IGF-1R↓, "highlight2" >MMP↓, "highlight2" >Apoptosis↑, "highlight2" >NA?,
97- QC,  HPT,    Effects of the flavonoid drug Quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo
- in-vitro, Pca, PC3
"highlight2" >HSP72↑, "highlight2" >TumCG↓, "highlight2" >eff↑, "highlight2" >ChemoSen↑, "highlight2" >RadioS↑,
96- QC,  docx,    Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
"highlight2" >PI3K/Akt↓, "highlight2" >Ki-67↓, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >EpCAM↓, "highlight2" >Twist↓, "highlight2" >E-cadherin↑, "highlight2" >P-gp↓, "highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCI↓,
95- QC,    Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent
- in-vitro, Pca, PC3
"highlight2" >p‑ERK↓, "highlight2" >p‑STAT3↓, "highlight2" >p‑Akt↓, "highlight2" >N-cadherin↓, "highlight2" >Vim↓, "highlight2" >cycD1/CCND1↓, "highlight2" >Snail↓, "highlight2" >Slug↓, "highlight2" >Twist↓, "highlight2" >PCNA↓, "highlight2" >EGFR↓, "highlight2" >chemoPv↑,
94- QC,  HPT,    Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, JCA-1
"highlight2" >HSP70/HSPA5↓, "highlight2" >TumCCA↑, "highlight2" >TumCG↓, "highlight2" >eff↑,
93- QC,    Chemical Proteomics Identifies Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1 as the Molecular Target of Quercetin in Its Anti-cancer Effects in PC-3 Cells
- in-vitro, Pca, PC3
"highlight2" >hnRNPA1↓, "highlight2" >Casp3↑, "highlight2" >Casp7↑, "highlight2" >TumCD↑, "highlight2" >IAP1↓,
92- QC,    Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways
- vitro+vivo, Pca, HUVECs - vitro+vivo, Pca, PC3
"highlight2" >VEGFR2↓, "highlight2" >HemoG↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >P70S6K↓, "highlight2" >angioG↓,
91- QC,    The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
"highlight2" >CDK2↓, "highlight2" >cycE/CCNE↓, "highlight2" >cycD1/CCND1↓, "highlight2" >ATFs↑, "highlight2" >GRP78/BiP↑, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >ER Stress↑, "highlight2" >CHOP↑, "highlight2" >TumCCA↑, "highlight2" >DNAdam↑, "highlight2" >AIF↑, "highlight2" >Ca+2↑, "highlight2" >MMP↓,
90- QC,  HP,    Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA‑21
- in-vitro, Pca, PC3
"highlight2" >ROS↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑PARP↑, "highlight2" >miR-21↓, "highlight2" >PDCD4↑, "highlight2" >TAC↑, "highlight2" >tumCV↓, "highlight2" >TumCI↓,
89- QC,  doxoR,    Quercetin reverses the doxorubicin resistance of prostate cancer cells by downregulating the expression of c-met
- in-vitro, Pca, PC3
"highlight2" >PI3K/Akt↓, "highlight2" >cMET↓, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >MMP↓, "highlight2" >ChemoSen↑, "highlight2" >ROS↑,
88- QC,  PacT,    Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production
- vitro+vivo, Pca, PC3
"highlight2" >ROS↑, "highlight2" >ER Stress↑, "highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >TumCMig↓, "highlight2" >GRP78/BiP↑, "highlight2" >CHOP↑, "highlight2" >TumCG↓,
87- QC,    Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >ROS⇅, "highlight2" >BAX↑, "highlight2" >PUMA⇅, "highlight2" >β-catenin/ZEB1↓, "highlight2" >Shc↓, "highlight2" >TAp63α↑, "highlight2" >MAPK↑, "highlight2" >p‑p42↑, "highlight2" >p‑p44↑, "highlight2" >BIM↑,
69- QC,    Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
"highlight2" >TRAIL↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >Casp8↑, "highlight2" >DR5↑,
85- QC,    Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)
- in-vitro, Pca, PC3
"highlight2" >uPA↓, "highlight2" >uPAR↓, "highlight2" >EGFR↓, "highlight2" >NRAS↓, "highlight2" >Jun↓, "highlight2" >NF-kB↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >p38↑, "highlight2" >MAPK↑, "highlight2" >cJun↓, "highlight2" >cFos↓, "highlight2" >Raf↓, "highlight2" >TumCI↓, "highlight2" >TumCMig↓,
84- QC,    Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression
- in-vitro, Pca, PC3
"highlight2" >P21↑, "highlight2" >cDC2↓, "highlight2" >CDK1↓, "highlight2" >CycB/CCNB1↓, "highlight2" >Casp3↑, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >BAX↑, "highlight2" >pRB↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑,
74- QC,  EGCG,    Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer
- Human, Pca, NA
"highlight2" >BioAv↑, "highlight2" >BioAv↑, "highlight2" >toxicity↓,
70- QC,    Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
"highlight2" >PSA↓, "highlight2" >AR↓, "highlight2" >NKX3.1↓, "highlight2" >HK2↓,
71- QC,    Role of Bax in quercetin-induced apoptosis in human prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PrEC - in-vitro, Pca, YPEN-1 - in-vitro, Pca, HCT116
"highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >PARP↑, "highlight2" >BAD↓, "highlight2" >BAX↑, "highlight2" >PI3K/Akt↓, "highlight2" >Cyt‑c↑, "highlight2" >selectivity↑,
72- QC,  Se,    Selenium- or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activity
- in-vitro, Pca, PECs - in-vitro, Pca, LNCaP - in-vitro, Pca, NIH-3T3
"highlight2" >AR↓,
73- QC,    The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
"highlight2" >HSP90↓, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >TumCG↓, "highlight2" >TumCD↑, "highlight2" >selectivity↑, "highlight2" >toxicity↓,
75- QC,  ENZ,    Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells
- in-vitro, Pca, HEK293 - in-vitro, NA, 22Rv1 - in-vitro, NA, C4-2B
"highlight2" >hnRNPA1↓, "highlight2" >PSA↓, "highlight2" >NKX3.1↓, "highlight2" >FKBP5↓, "highlight2" >UBE2C↓, "highlight2" >AR-FL↓, "highlight2" >AR-V7↑, "highlight2" >AR↓, "highlight2" >eff↑, "highlight2" >TumVol↓, "highlight2" >BioAv↓,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
"highlight2" >aSmase↝, "highlight2" >Diablo↑, "highlight2" >Fas↓, "highlight2" >Hsc70↓, "highlight2" >Hif1a↓, "highlight2" >Mcl-1↓, "highlight2" >HSP90↓, "highlight2" >FLT4↓, "highlight2" >EphB4↓, "highlight2" >DNA-PK↓, "highlight2" >PARP1↓, "highlight2" >ATM↓, "highlight2" >XIAP↝, "highlight2" >PLC↓, "highlight2" >GnT-V↝, "highlight2" >heparanase↝, "highlight2" >NM23↑, "highlight2" >CSR1↑, "highlight2" >SPP1↓, "highlight2" >DNMT1↓, "highlight2" >HDAC4↓, "highlight2" >CXCR4↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >FBXW7↝, "highlight2" >AMACR↓, "highlight2" >cycD1/CCND1↓, "highlight2" >IGF-1R↓, "highlight2" >IMPDH1↓, "highlight2" >IMPDH2↓, "highlight2" >HEC1↓, "highlight2" >NHE1↓, "highlight2" >NOS2↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
"highlight2" >Casp3↑, "highlight2" >Casp7↑, "highlight2" >Bcl-2↓, "highlight2" >survivin↓, "highlight2" >XIAP↓, "highlight2" >EMT↓, "highlight2" >Vim↓, "highlight2" >Slug↓, "highlight2" >Snail↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >LEF1↓, "highlight2" >TCF↓, "highlight2" >eff↑, "highlight2" >CSCs↓, "highlight2" >TumCG↓, "highlight2" >tumCV↓,
78- QC,    Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells
- in-vitro, Pca, PC3
"highlight2" >IGF-1↓, "highlight2" >IGF-2↓, "highlight2" >IGFBP3↑, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >Casp3↑, "highlight2" >Apoptosis↑, "highlight2" >BAX↑, "highlight2" >DNAdam↑,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
"highlight2" >GSH↑, "highlight2" >SOD↑, "highlight2" >Catalase↑, "highlight2" >GPx↑, "highlight2" >GSR↑, "highlight2" >IGF-1R↓, "highlight2" >Akt↓, "highlight2" >AR↓, "highlight2" >TumCP↓, "highlight2" >lipid-P↓, "highlight2" >H2O2↓, "highlight2" >Raf↓, "highlight2" >p‑MEK↓, "highlight2" >Bcl-2↑, "highlight2" >Bcl-xL↑, "highlight2" >Casp3↑, "highlight2" >Casp8↑, "highlight2" >Casp9↑,
80- QC,    Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway
- in-vitro, Pca, PC3
"highlight2" >Vim↓, "highlight2" >ERK↓, "highlight2" >Snail↓, "highlight2" >Slug↓, "highlight2" >Twist↓, "highlight2" >EGFR↓, "highlight2" >p‑Akt↓, "highlight2" >EGFR↓, "highlight2" >N-cadherin↓, "highlight2" >TumMeta↓, "highlight2" >EMT↓,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
"highlight2" >COMT↓, "highlight2" >MRP1↓, "highlight2" >Ki-67↓, "highlight2" >Bax:Bcl2↑, "highlight2" >AR↓, "highlight2" >Akt↓, "highlight2" >p‑ERK↓, "highlight2" >COMT↓, "highlight2" >eff↑, "highlight2" >chemoPv↑, "highlight2" >BioAv↑,
82- QC,  ATG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, LNCaP
"highlight2" >AR↓, "highlight2" >PI3K/Akt↓, "highlight2" >miR-21↓, "highlight2" >STAT3↓, "highlight2" >BAD↓, "highlight2" >PRAS40↓, "highlight2" >GSK‐3β↓, "highlight2" >PSA↓, "highlight2" >NKX3.1↑, "highlight2" >Bax:Bcl2↑, "highlight2" >miR-19b↓, "highlight2" >miR-148a↓, "highlight2" >AMPKα↓, "highlight2" >TumCP↓, "highlight2" >chemoPv↑, "highlight2" >TumCMig↓,
83- QC,    Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3
- in-vitro, Pca, PC3
"highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >BAX↑, "highlight2" >IGFBP3↑,
3602- QC,    The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
- in-vivo, AD, NA
"highlight2" >*BACE↓, "highlight2" >*cognitive↑, "highlight2" >*ROS↓, "highlight2" >*lipid-P↓, "highlight2" >*iNOS↓, "highlight2" >*COX2↓, "highlight2" >*BBB↑, "highlight2" >*neuroP↑, "highlight2" >*other↓, "highlight2" >*memory↑,
3609- QC,    Factors modulating bioavailability of quercetin-related flavonoids and the consequences of their vascular function
- Review, Var, NA
"highlight2" >*BioAv↑,
3608- QC,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
"highlight2" >AntiCan↑, "highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*NF-kB↓, "highlight2" >*MAPK↓, "highlight2" >*PI3K↑, "highlight2" >*Akt↑, "highlight2" >*NRF2↑,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
"highlight2" >*neuroP↑, "highlight2" >*NRF2↑, "highlight2" >*PONs↑, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*SIRT1↑, "highlight2" >*eff↑, "highlight2" >*ROS↓, "highlight2" >*cognitive↑, "highlight2" >*eff↑, "highlight2" >*lipid-P↓, "highlight2" >*GSH↑, "highlight2" >*GPx↑, "highlight2" >*SOD↑, "highlight2" >*NRF2↑,
3606- QC,    The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial
- Trial, Arthritis, NA
"highlight2" >*motorD↑, "highlight2" >*Pain↓, "highlight2" >*TNF-α↓, "highlight2" >*IL8↓, "highlight2" >*IL6↓, "highlight2" >*IL1β↓, "highlight2" >*NF-kB↓, "highlight2" >*p38↓,
3605- QC,    Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease
- Review, AD, NA
"highlight2" >*Aβ↓, "highlight2" >*ROS↓, "highlight2" >*lipid-P↓, "highlight2" >*Apoptosis↓,
3604- QC,    Quercetin enrich diet during the early-middle not middle-late stage of alzheimer’s disease ameliorates cognitive dysfunction
- in-vivo, AD, NA
"highlight2" >*cognitive↑, "highlight2" >*Aβ↓, "highlight2" >*neuroP↑, "highlight2" >*BACE↓, "highlight2" >*p‑SMAD2↓, "highlight2" >*p‑STAT3↓, "highlight2" >*SPARC↓,
3603- QC,    Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus
- Review, AD, NA - Review, Diabetic, NA
"highlight2" >*MAPK↓, "highlight2" >*neuroP↑, "highlight2" >*ROS↓, "highlight2" >*Akt↓, "highlight2" >*PI3K↓, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓, "highlight2" >*VEGF↓, "highlight2" >*EGFR↓, "highlight2" >*Casp3↓, "highlight2" >*Bcl-2↓, "highlight2" >*IL1β↓,
3611- QC,    Quercetin and vitamin C supplementation: effects on lipid profile and muscle damage in male athletes
- Trial, Nor, NA
"highlight2" >*eff↝, "highlight2" >*LDH↓,
3601- QC,    Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid
- Review, Var, NA - Review, AD, NA
"highlight2" >*Inflam↓, "highlight2" >*cardioP↑, "highlight2" >AntiCan↑, "highlight2" >AntiTum↑, "highlight2" >*neuroP↑, "highlight2" >*cognitive↑, "highlight2" >*ROS↓, "highlight2" >*BP↓, "highlight2" >*LDL↓,
3534- QC,  Lyco,    Synergistic protection of quercetin and lycopene against oxidative stress via SIRT1-Nox4-ROS axis in HUVEC cells
- in-vitro, Nor, HUVECs
"highlight2" >*ROS↓, "highlight2" >*NOX4↓, "highlight2" >*Inflam↓, "highlight2" >*NF-kB↓, "highlight2" >*p65↓, "highlight2" >*SIRT1↑, "highlight2" >*cardioP↑, "highlight2" >*IL6↓, "highlight2" >*COX2↓,
3381- QC,    Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
- in-vitro, Cerv, HeLa
"highlight2" >SREBP1↓, "highlight2" >TumCP↓, "highlight2" >TumCD↑, "highlight2" >AMPK↑, "highlight2" >SREBP1↓, "highlight2" >FASN↓, "highlight2" >ACC↓,
3380- QC,    Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
- Review, Var, NA - Review, Park, NA - Review, AD, NA
"highlight2" >JAK↓, "highlight2" >STAT↓, "highlight2" >Inflam↓, "highlight2" >NO↓, "highlight2" >COX2↓, "highlight2" >CRP↓, "highlight2" >selectivity↑, "highlight2" >*neuroP↑, "highlight2" >STAT3↓, "highlight2" >cycD1/CCND1↓, "highlight2" >MMP2↓, "highlight2" >STAT4↓, "highlight2" >JAK2↓, "highlight2" >TumCP↓, "highlight2" >Diff↓, "highlight2" >*eff↑, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*Aβ↓,
3379- QC,    The Effect of Quercetin Nanosuspension on Prostate Cancer Cell Line LNCaP via Hedgehog Signaling Pathway
- in-vitro, Pca, LNCaP
"highlight2" >tumCV↓, "highlight2" >HH↓,
3378- QC,    CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia
- in-vitro, AML, NA
"highlight2" >CK2↓, "highlight2" >PI3K↓, "highlight2" >TumCD↑, "highlight2" >Akt↓, "highlight2" >Mcl-1↓, "highlight2" >PTEN↑,
3377- QC,    Quercetin inhibits a large panel of kinases implicated in cancer cell biology
"highlight2" >PDGF↓, "highlight2" >FLT3↓, "highlight2" >JAK3↓, "highlight2" >MET↓, "highlight2" >RET↓, "highlight2" >FGFR2↓, "highlight2" >other↓,
3339- QC,    Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas
- in-vitro, GBM, C6 - in-vitro, GBM, IMR32
"highlight2" >BBB↑, "highlight2" >tumCV↓, "highlight2" >TumCMig↓, "highlight2" >Rac1↓, "highlight2" >p66Shc↓, "highlight2" >ROS↓,
4787- QC,    Quercetin: A Phytochemical with Pro-Apoptotic Effects in Colon Cancer Cells
- Review, CRC, NA
"highlight2" >Inflam↓, "highlight2" >AntiCan↑, "highlight2" >Apoptosis↑, "highlight2" >MMP↓, "highlight2" >P53↑, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >Bcl-2↓, "highlight2" >NF-kB↓, "highlight2" >IL6↓, "highlight2" >IL1β↓, "highlight2" >*antiOx↑, "highlight2" >*lipid-P↓, "highlight2" >*ROS↓, "highlight2" >MAPK↓, "highlight2" >JAK↓, "highlight2" >STAT↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >chemoP↑, "highlight2" >ROS⇅, "highlight2" >DNAdam↑, "highlight2" >ChemoSen↝,
5031- QC,    Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells
- in-vitro, AML, APL NB4
"highlight2" >NRF2↓, "highlight2" >ROS↑, "highlight2" >Apoptosis↑,
5030- QC,    Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
- in-vivo, Nor, NA
"highlight2" >*MitoP↑, "highlight2" >*NRF2↑, "highlight2" >eff↑, "highlight2" >*eff↓, "highlight2" >*GutMicro↑,
5029- QC,    Molecular mechanisms of action of quercetin in cancer: recent advances
- in-vitro, Liver, HepG2
"highlight2" >NRF2↑, "highlight2" >NF-kB↓, "highlight2" >COX2↓,
5028- QC,    Quercetin inhibited LPS-induced cytokine storm by interacting with the AKT1-FoxO1 and Keap1-Nrf2 signaling pathway in macrophages
- vitro+vivo, Nor, RAW264.7
"highlight2" >*ROS↓, "highlight2" >*Keap1↓, "highlight2" >*NRF2↑,
5027- QC,    NRF2 Is Targeted By the Polyphenol Quercetin and Induces Apoptosis, in Part, through up Regulation of Pro Apoptotic Mirs
- in-vivo, AML, NA
"highlight2" >HDAC4↓, "highlight2" >NRF2↓, "highlight2" >p‑NRF2↓, "highlight2" >miR-133a-3p↑, "highlight2" >miR-206↑,
5026- QC,    Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes
- in-vitro, GC, NA
"highlight2" >SLC1A5↓, "highlight2" >ROS↑, "highlight2" >Iron↓, "highlight2" >NRF2↓, "highlight2" >GPx4↓, "highlight2" >Ferroptosis↑,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*NRF2↓, "highlight2" >*ROS↓, "highlight2" >*cardioP↑, "highlight2" >*HO-1↑, "highlight2" >*Catalase↑, "highlight2" >*GPx↑, "highlight2" >*NQO1↑, "highlight2" >*SIRT1↑,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
"highlight2" >*AntiCan↑, "highlight2" >*Inflam↓, "highlight2" >*Bacteria↓, "highlight2" >*AntiDiabetic↑, "highlight2" >*ROS↓, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*GSH↑, "highlight2" >*NRF2↑, "highlight2" >*Trx↑, "highlight2" >*IronCh↑, "highlight2" >*MDA↑, "highlight2" >cycD1/CCND1↓, "highlight2" >PI3K↓, "highlight2" >Casp3↑, "highlight2" >BAX↑, "highlight2" >ChemoSen↑, "highlight2" >ROS↑, "highlight2" >eff↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >Akt↓, "highlight2" >ERK↓,
3610- QC,    Bioavailability of quercetin: problems and promises
"highlight2" >*BioAv↓, "highlight2" >*BioAv↑, "highlight2" >*BioAv↑,
4686- QC,    Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling
- in-vitro, EC, EMN8 - in-vitro, EC, EMN21
"highlight2" >CSCs↓, "highlight2" >ALDH1A1↓, "highlight2" >cMyc↓, "highlight2" >Nanog↓, "highlight2" >OCT4↓, "highlight2" >STAT3↓, "highlight2" >JAK2↓, "highlight2" >STAT3↓, "highlight2" >eff↑,
4665- QC,  Ash,  Api,    Targeting cancer stem cells by nutraceuticals for cancer therapy
- Review, Var, NA
"highlight2" >CSCs↓,
4297- QC,    Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
- in-vitro, AD, SH-SY5Y
"highlight2" >*AMPK↑, "highlight2" >*IRE1↓, "highlight2" >*p‑PERK↓, "highlight2" >*p‑tau↓, "highlight2" >*cognitive↑, "highlight2" >*antiOx↑, "highlight2" >*ER Stress↓, "highlight2" >*Inflam↓, "highlight2" >*neuroP↑, "highlight2" >*TXNIP↓, "highlight2" >*NLRP3↓,
4296- QC,    A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders
- Review, AD, NA
"highlight2" >*Inflam↓, "highlight2" >*COX2↓, "highlight2" >*5LO↓, "highlight2" >*antiOx↑, "highlight2" >*BioAv↝, "highlight2" >*GPx↑, "highlight2" >*SOD↑, "highlight2" >*Ach↑, "highlight2" >*4-HNE↓, "highlight2" >*CREB↑, "highlight2" >*BDNF↑, "highlight2" >*ROS↓, "highlight2" >*GSH↑, "highlight2" >*IL1β↓, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓,
4162- QC,    Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway
- in-vivo, Stroke, NA
"highlight2" >*neuroP↑, "highlight2" >*BDNF↑, "highlight2" >*TrkB↑, "highlight2" >*p‑Akt↑,
3796- QC,  BBR,    Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances
- Review, AD, NA
"highlight2" >*CDK5↓,
3376- QC,    Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy
- in-vitro, BC, MCF-7 - in-vitro, Lung, A549
"highlight2" >CDK6↓, "highlight2" >tumCV↓, "highlight2" >Apoptosis↑, "highlight2" >ROS↓, "highlight2" >eff↑,
3349- QC,    Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression
- in-vivo, Sepsis, NA
"highlight2" >*Sepsis↓, "highlight2" >*ROS↓, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*HMGB1↓, "highlight2" >*Inflam↓, "highlight2" >*TAC↑,
3357- QC,    The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes
- in-vitro, AML, HL-60 - NA, NA, U937
"highlight2" >DNMT1↓, "highlight2" >DNMT3A↓, "highlight2" >HDAC↓, "highlight2" >ac‑H3↑, "highlight2" >ac‑H4↑, "highlight2" >BAX↑, "highlight2" >APAF1↑, "highlight2" >BNIP3↑, "highlight2" >STAT3↑,
3356- QC,    Targeting DNA methyltransferases for cancer therapy
- Review, Var, NA
"highlight2" >DNMTs↓,
3355- QC,    Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks
- in-vitro, Cerv, HeLa
"highlight2" >DNAdam↑, "highlight2" >ROS↑, "highlight2" >*antiOx↑, "highlight2" >TOP2↓, "highlight2" >γH2AX↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
"highlight2" >*ROS↓, "highlight2" >*IronCh↓, "highlight2" >*lipid-P↓, "highlight2" >*GSH↑, "highlight2" >*NRF2↑, "highlight2" >TumCCA↑, "highlight2" >ER Stress↑, "highlight2" >P53↑, "highlight2" >CDK2↓, "highlight2" >cycA1/CCNA1↓, "highlight2" >CycB/CCNB1↓, "highlight2" >cycE/CCNE↓, "highlight2" >cycD1/CCND1↓, "highlight2" >PCNA↓, "highlight2" >P21↑, "highlight2" >p27↑, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >STAT3↓, "highlight2" >cFLIP↓, "highlight2" >cMyc↓, "highlight2" >survivin↓, "highlight2" >DR5↓, "highlight2" >*Inflam↓, "highlight2" >*IL6↓, "highlight2" >*IL8↓, "highlight2" >COX2↓, "highlight2" >5LO↓, "highlight2" >*cardioP↑, "highlight2" >*FASN↓, "highlight2" >*AntiAg↑, "highlight2" >*MDA↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
"highlight2" >tumCV↓, "highlight2" >selectivity↑, "highlight2" >TumCCA↑, "highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >Apoptosis↑, "highlight2" >TumMeta↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >TIMP1↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >*Inflam↓, "highlight2" >*neuroP↑, "highlight2" >*cardioP↑, "highlight2" >p38↓, "highlight2" >MAPK↓, "highlight2" >Twist↓, "highlight2" >P21↓, "highlight2" >cycD1/CCND1↓, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >p‑Akt↓, "highlight2" >p‑ERK↓, "highlight2" >CD44↓, "highlight2" >CD24↓, "highlight2" >ChemoSen↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >AIF↑, "highlight2" >ROS↑, "highlight2" >Ca+2↑, "highlight2" >Hif1a↓, "highlight2" >VEGF↓,
3352- QC,    A review of quercetin: Antioxidant and anticancer properties
- Review, Var, NA
"highlight2" >*antiOx↑, "highlight2" >*lipid-P↓, "highlight2" >*TNF-α↓, "highlight2" >*NF-kB↓, "highlight2" >*COX2↓, "highlight2" >*IronCh↑, "highlight2" >P53↓, "highlight2" >TumCCA↑, "highlight2" >HSPs↓, "highlight2" >P21↓, "highlight2" >RAS↓, "highlight2" >ER(estro)↑, "highlight2" >OS?,
3351- QC,    Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria
- Review, AD, NA
"highlight2" >*ROS↓, "highlight2" >*neuroP↑,
3350- QC,    Quercetin and the mitochondria: A mechanistic view
- Review, NA, NA
"highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*NRF2↑, "highlight2" >ROS⇅, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*PPARα↑, "highlight2" >*PGC-1α↑, "highlight2" >*SIRT1↑, "highlight2" >*ATP↑, "highlight2" >ATP↓, "highlight2" >ERK↓, "highlight2" >cl‑PARP↑, "highlight2" >Casp9↑, "highlight2" >Casp8↑, "highlight2" >BAX↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >Casp3↑, "highlight2" >HSP27↓, "highlight2" >HSP72↓, "highlight2" >RAS↓, "highlight2" >Raf↓,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
"highlight2" >α-SMA↓, "highlight2" >α-SMA↑, "highlight2" >TumCP↓, "highlight2" >tumCV↓, "highlight2" >TumVol↓, "highlight2" >TumCI↓, "highlight2" >TumMeta↓, "highlight2" >TumCMig↓, "highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >BioAv↓, "highlight2" >*neuroP↑, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓, "highlight2" >*Aβ↓, "highlight2" >*cardioP↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >EMT↓, "highlight2" >MMPs↓, "highlight2" >Twist↓, "highlight2" >Slug↓, "highlight2" >Ca+2↑, "highlight2" >AIF↑, "highlight2" >Endon↑, "highlight2" >P-gp↓, "highlight2" >LDH↑, "highlight2" >HK2↓, "highlight2" >PKA↓, "highlight2" >Glycolysis↓, "highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >GRP78/BiP↑, "highlight2" >Casp12↑, "highlight2" >CHOP↑,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, NA, NA
"highlight2" >*IronCh↑, "highlight2" >*ROS↓, "highlight2" >*AntiAg↑, "highlight2" >*Fenton↓, "highlight2" >*lipid-P↓, "highlight2" >*hepatoP↑, "highlight2" >*RenoP↑, "highlight2" >HIF-1↑, "highlight2" >ROS↑,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
"highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*Inflam↓, "highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >*cardioP↑, "highlight2" >*BP↓, "highlight2" >TumMeta↓, "highlight2" >MDR1↓, "highlight2" >NADPH↓, "highlight2" >ChemoSen↑, "highlight2" >MMPs↓, "highlight2" >TIMP2↑, "highlight2" >*NLRP3↓, "highlight2" >*IFN-γ↑, "highlight2" >*COX2↓, "highlight2" >*NF-kB↓, "highlight2" >*MAPK↓, "highlight2" >*CRP↓, "highlight2" >*IL6↓, "highlight2" >*TNF-α↓, "highlight2" >*IL1β↓, "highlight2" >*TLR4↑, "highlight2" >*PKCδ↓, "highlight2" >*AP-1↓, "highlight2" >*ICAM-1↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*lipid-P↓, "highlight2" >*neuroP↑, "highlight2" >*eff↑, "highlight2" >*memory↑, "highlight2" >*cognitive↑, "highlight2" >*AChE↓, "highlight2" >*BioAv↑, "highlight2" >*BioAv↑, "highlight2" >*BioAv↑, "highlight2" >*BioAv↑, "highlight2" >*BioAv↑,
3346- QC,    Regulation of the Intracellular ROS Level Is Critical for the Antiproliferative Effect of Quercetin in the Hepatocellular Carcinoma Cell Line HepG2
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
"highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >P53↑, "highlight2" >TumCP↓, "highlight2" >ROS↓, "highlight2" >antiOx↑, "highlight2" >HO-1↑, "highlight2" >CDK1↓,
3344- QC,    Quercetin induced ROS production triggers mitochondrial cell death of human embryonic stem cells
- in-vitro, Nor, hESC
"highlight2" >mt-ROS↑, "highlight2" >selectivity↑, "highlight2" >P53↑, "highlight2" >ROS⇅,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
"highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*angioG↓, "highlight2" >*Inflam↓, "highlight2" >*BioAv↓, "highlight2" >*Half-Life↑, "highlight2" >*GSH↑, "highlight2" >*SOD↑, "highlight2" >*Catalase↑, "highlight2" >*Nrf1↑, "highlight2" >*BP↓, "highlight2" >*cardioP↑, "highlight2" >*IL10↓, "highlight2" >*TNF-α↓, "highlight2" >*Aβ↓, "highlight2" >*GSK‐3β↓, "highlight2" >*tau↓, "highlight2" >*neuroP↑, "highlight2" >*Pain↓, "highlight2" >*COX2↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*IL1β↓, "highlight2" >*IL17↓, "highlight2" >*MCP1↓, "highlight2" >PKCδ↓, "highlight2" >ERK↓, "highlight2" >BAX↓, "highlight2" >cMyc↓, "highlight2" >KRAS↓, "highlight2" >ROS↓, "highlight2" >selectivity↑, "highlight2" >tumCV↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >eff↑, "highlight2" >P-gp↓, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >CycB/CCNB1↓, "highlight2" >CDK1↓, "highlight2" >CDK4↓, "highlight2" >CDK2↓, "highlight2" >TOP2↓, "highlight2" >Cyt‑c↑, "highlight2" >cl‑PARP↑, "highlight2" >MMP↓, "highlight2" >HSP70/HSPA5↓, "highlight2" >HSP90↓, "highlight2" >MDM2↓, "highlight2" >RAS↓, "highlight2" >eff↑,
3342- QC,    Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells — up regulation of Nrf2 expression and down regulation of NF-κB and COX-2
- in-vitro, Nor, HepG2
"highlight2" >*ROS↓, "highlight2" >*Ca+2↓, "highlight2" >*NF-kB↓, "highlight2" >*NRF2↑, "highlight2" >*COX2↓, "highlight2" >*Inflam↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
"highlight2" >*antiOx↑, "highlight2" >*BioAv↑, "highlight2" >*GSH↑, "highlight2" >*AChE↓, "highlight2" >*BChE↓, "highlight2" >*H2O2↓, "highlight2" >*lipid-P↓, "highlight2" >*SOD↑, "highlight2" >*SOD2↑, "highlight2" >*Catalase↑, "highlight2" >*GPx↑, "highlight2" >*neuroP↑, "highlight2" >*HO-1↑, "highlight2" >*cardioP↑, "highlight2" >*MDA↓, "highlight2" >*NF-kB↓, "highlight2" >*IKKα↓, "highlight2" >*ROS↓, "highlight2" >*PI3K↑, "highlight2" >*Akt↑, "highlight2" >*hepatoP↑, "highlight2" >P53↑, "highlight2" >BAX↑, "highlight2" >IGF-1R↓, "highlight2" >Akt↓, "highlight2" >AR↓, "highlight2" >TumCP↓, "highlight2" >GSH↑, "highlight2" >SOD↑, "highlight2" >Catalase↑, "highlight2" >lipid-P↓, "highlight2" >*TNF-α↓, "highlight2" >*Ca+2↓,
3340- QC,    Quercetin regulates inflammation, oxidative stress, apoptosis, and mitochondrial structure and function in H9C2 cells by promoting PVT1 expression
- in-vitro, Nor, H9c2
"highlight2" >*Inflam↓, "highlight2" >*ROS↓, "highlight2" >*Apoptosis↓,
3366- QC,    Quercetin Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis by Inhibiting the Glucose Regulatory Protein 78 Activation
- in-vivo, IBD, NA
"highlight2" >*Apoptosis↓, "highlight2" >*Inflam↓, "highlight2" >*ROS↓, "highlight2" >*ER Stress↓, "highlight2" >*TNF-α↓, "highlight2" >*MPO↓, "highlight2" >*p‑JNK↓, "highlight2" >*Casp12↓, "highlight2" >*GRP78/BiP↓, "highlight2" >*antiOx↑, "highlight2" >*NF-kB↓,
3375- QC,    Quercetin Mediated TET1 Expression Through MicroRNA-17 Induced Cell Apoptosis in Melanoma Cells
- in-vitro, Melanoma, B16-BL6
"highlight2" >TET1↑, "highlight2" >TumCI↓,
3373- QC,    The Effect of Quercetin in the Yishen Tongluo Jiedu Recipe on the Development of Prostate Cancer through the Akt1-related CXCL12/ CXCR4 Pathway
- in-vitro, Pca, DU145
"highlight2" >TumCP↓, "highlight2" >Casp3↑, "highlight2" >Bcl-2↓, "highlight2" >Apoptosis↑, "highlight2" >TumCI↓, "highlight2" >TumCMig↓, "highlight2" >CXCL12↓, "highlight2" >CXCR4↓,
3372- QC,  FIS,  KaempF,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
"highlight2" >ROCK1↑, "highlight2" >TumCCA↓, "highlight2" >HSPs↓, "highlight2" >RAS↓, "highlight2" >ROS↑, "highlight2" >Ca+2↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >Endon↑, "highlight2" >MMP9↓, "highlight2" >MMP2↓, "highlight2" >MMP7↓, "highlight2" >MMP-10↓, "highlight2" >VEGF↓, "highlight2" >NF-kB↓, "highlight2" >p65↓, "highlight2" >iNOS↓, "highlight2" >COX2↓, "highlight2" >uPA↓, "highlight2" >PI3K↓, "highlight2" >FAK↓, "highlight2" >MEK↓, "highlight2" >ERK↓, "highlight2" >JNK↓, "highlight2" >p38↓, "highlight2" >cJun↓, "highlight2" >FOXO3↑,
3371- QC,    Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways
- in-vitro, GBM, T98G
"highlight2" >TIMP2↑, "highlight2" >TumCG↓, "highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >MMP↓, "highlight2" >ROS↑, "highlight2" >Bax:Bcl2↑, "highlight2" >cl‑Casp9↑, "highlight2" >cl‑Casp3↑, "highlight2" >DNAdam↑, "highlight2" >γH2AX↑, "highlight2" >MGMT↓, "highlight2" >cl‑PARP↑,
3370- QC,    Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3)
- in-vitro, Pca, PC3
"highlight2" >MMP2↓, "highlight2" >MMP9↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
"highlight2" >FAK↓, "highlight2" >TumCCA↑, "highlight2" >p‑pRB↓, "highlight2" >CDK2↑, "highlight2" >CycB/CCNB1↓, "highlight2" >CDK1↓, "highlight2" >EMT↓, "highlight2" >PI3K↓, "highlight2" >MAPK↓, "highlight2" >Wnt↓, "highlight2" >ROS↑, "highlight2" >miR-21↑, "highlight2" >Akt↓, "highlight2" >NF-kB↓, "highlight2" >FasL↑, "highlight2" >Bak↑, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >Casp3↓, "highlight2" >Casp9↑, "highlight2" >P53↑, "highlight2" >p38↑, "highlight2" >MAPK↑, "highlight2" >Cyt‑c↑, "highlight2" >PARP↓, "highlight2" >CHOP↑, "highlight2" >ROS↓, "highlight2" >LDH↑, "highlight2" >GRP78/BiP↑, "highlight2" >ERK↑, "highlight2" >MDA↓, "highlight2" >SOD↑, "highlight2" >GSH↑, "highlight2" >NRF2↑, "highlight2" >VEGF↓, "highlight2" >PDGF↓, "highlight2" >EGF↓, "highlight2" >FGF↓, "highlight2" >TNF-α↓, "highlight2" >TGF-β↓, "highlight2" >VEGFR2↓, "highlight2" >EGFR↓, "highlight2" >FGFR1↓, "highlight2" >mTOR↓, "highlight2" >cMyc↓, "highlight2" >MMPs↓, "highlight2" >LC3B-II↑, "highlight2" >Beclin-1↑, "highlight2" >IL1β↓, "highlight2" >CRP↓, "highlight2" >IL10↓, "highlight2" >COX2↓, "highlight2" >IL6↓, "highlight2" >TLR4↓, "highlight2" >Shh↓, "highlight2" >HER2/EBBR2↓, "highlight2" >NOTCH↓, "highlight2" >DR5↑, "highlight2" >HSP70/HSPA5↓, "highlight2" >CSCs↓, "highlight2" >angioG↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >IGFBP3↑, "highlight2" >uPA↓, "highlight2" >uPAR↓, "highlight2" >RAS↓, "highlight2" >Raf↓, "highlight2" >TSP-1↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
"highlight2" >*Inflam↓, "highlight2" >*antiOx↑, "highlight2" >*AntiCan↑, "highlight2" >Casp3↓, "highlight2" >p‑Akt↓, "highlight2" >p‑mTOR↓, "highlight2" >p‑ERK↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >Hif1a↓, "highlight2" >AntiAg↓, "highlight2" >VEGFR2↓, "highlight2" >EMT↓, "highlight2" >EGFR↓, "highlight2" >MMP2↓, "highlight2" >MMP↓, "highlight2" >TumMeta↓, "highlight2" >MMPs↓, "highlight2" >Akt↓, "highlight2" >Snail↓, "highlight2" >N-cadherin↓, "highlight2" >Vim↓, "highlight2" >E-cadherin↑, "highlight2" >STAT3↓, "highlight2" >TGF-β↓, "highlight2" >ROS↓, "highlight2" >P53↑, "highlight2" >BAX↑, "highlight2" >PKCδ↓, "highlight2" >PI3K↓, "highlight2" >COX2↓, "highlight2" >cFLIP↓, "highlight2" >cycD1/CCND1↓, "highlight2" >cMyc↓, "highlight2" >IL6↓, "highlight2" >IL10↓, "highlight2" >Cyt‑c↑, "highlight2" >TumCCA↑, "highlight2" >DNMTs↓, "highlight2" >HDAC↓, "highlight2" >ac‑H3↑, "highlight2" >ac‑H4↑, "highlight2" >Diablo↑, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >PARP1↑, "highlight2" >eff↑, "highlight2" >PTEN↑, "highlight2" >VEGF↓, "highlight2" >NO↓, "highlight2" >iNOS↓, "highlight2" >ChemoSen↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >uPA↓, "highlight2" >CXCR4↓, "highlight2" >CXCL12↓, "highlight2" >CLDN2↓, "highlight2" >CDK6↓, "highlight2" >MMP9↓, "highlight2" >TSP-1↑, "highlight2" >Ki-67↓, "highlight2" >PCNA↓, "highlight2" >ROS↑, "highlight2" >ER Stress↑,
3367- QC,    Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments
- Review, Stroke, NA - Review, AD, NA
"highlight2" >*NRF2↑, "highlight2" >*neuroP↑, "highlight2" >*motorD↑, "highlight2" >*Inflam↓, "highlight2" >*cognitive↑,
3365- QC,    Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- in-vivo, Sepsis, NA
"highlight2" >*ER Stress↓, "highlight2" >*PDI↓, "highlight2" >*CHOP↓, "highlight2" >*GRP78/BiP↓, "highlight2" >*ATF6↓, "highlight2" >*PERK↓, "highlight2" >*IRE1↓, "highlight2" >*MMP↑, "highlight2" >*SOD↑, "highlight2" >*ROS↓, "highlight2" >*MDA↓, "highlight2" >*SIRT1↑, "highlight2" >*AMPK↑, "highlight2" >*Sepsis↓,
3364- QC,    Quercetin Protects Human Thyroid Cells against Cadmium Toxicity
- in-vitro, Nor, NA
"highlight2" >*MDA↓, "highlight2" >*GRP78/BiP↓,
3363- QC,    The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
- in-vitro, Nor, HBMECs
"highlight2" >*Apoptosis↓, "highlight2" >*angioG↑, "highlight2" >*NRF2↑, "highlight2" >*Keap1↓, "highlight2" >*ATF6↓, "highlight2" >*GRP78/BiP↓, "highlight2" >*CLDN5↑, "highlight2" >*ZO-1↑, "highlight2" >*MMP↑, "highlight2" >*BBB↑, "highlight2" >*ROS↓, "highlight2" >*ER Stress↓,
3362- QC,    The effect of quercetin on cervical cancer cells as determined by inducing tumor endoplasmic reticulum stress and apoptosis and its mechanism of action
- in-vitro, Cerv, HeLa
"highlight2" >Apoptosis↑, "highlight2" >cycD1/CCND1↓, "highlight2" >Casp3↑, "highlight2" >GRP78/BiP↑, "highlight2" >CHOP↑, "highlight2" >tumCV↓, "highlight2" >IRE1↑, "highlight2" >p‑PERK↑, "highlight2" >c-ATF6↑, "highlight2" >ER Stress↑,
3361- QC,    Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
- in-vivo, Nor, NA - in-vitro, NA, NA
"highlight2" >*BG↓, "highlight2" >*ROS↓, "highlight2" >*SOD↑, "highlight2" >*MDA↓, "highlight2" >*ER Stress↓, "highlight2" >*iNOS↓, "highlight2" >*CHOP↓, "highlight2" >*GRP78/BiP↓, "highlight2" >*antiOx↓, "highlight2" >*Inflam↓, "highlight2" >*JAK2↑, "highlight2" >*STAT3?,
3360- QC,    Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy
- Review, Var, NA
"highlight2" >HDAC↓, "highlight2" >DNMTs↓, "highlight2" >HMTs↓, "highlight2" >Let-7↑, "highlight2" >NOTCH↓,
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
"highlight2" >DNMTs↓, "highlight2" >HDAC↓, "highlight2" >HMTs↓, "highlight2" >DNMT3A↓, "highlight2" >EZH2↓, "highlight2" >HDAC1↓, "highlight2" >HDAC2↓, "highlight2" >HDAC6↓, "highlight2" >HDAC11↓, "highlight2" >G9a↓, "highlight2" >TIMP3↑, "highlight2" >PTEN↑, "highlight2" >SOCS1↑,
3358- QC,    Effects of quercetin on the DNA methylation pattern in tumor therapy: an updated review
- Review, NA, NA
"highlight2" >TET1↑, "highlight2" >DNMTs↓,
871- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
"highlight2" >T-Cell↑, "highlight2" >Neut↓, "highlight2" >Macrophages↓, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >other↓, "highlight2" >AntiTum↑, "highlight2" >TumVol↓,
105- RES,  QC,    The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell
- in-vitro, Pca, PANC1
"highlight2" >N-cadherin↓, "highlight2" >TNF-α↓, "highlight2" >ACTA2↓, "highlight2" >EMT↓, "highlight2" >CD133↓, "highlight2" >CSCs↓,
104- RES,  QC,    Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a
- in-vitro, Colon, HT-29
"highlight2" >Casp3↑, "highlight2" >PARP↑, "highlight2" >survivin↓, "highlight2" >miR-27a-3p↓, "highlight2" >Sp1/3/4↓, "highlight2" >ZBTB10↑, "highlight2" >ROS⇅, "highlight2" >TAC↑, "highlight2" >tumCV↓,
103- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- vitro+vivo, BC, 4T1
"highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Casp9↑, "highlight2" >T-Cell↑, "highlight2" >TGF-β↓,
3632- RosA,  CA,  QC,    Evolving Role of Natural Products from Traditional Medicinal Herbs in the Treatment of Alzheimer's Disease
- Review, AD, NA
"highlight2" >*AChE↓,
1309- TQ,  QC,    Thymoquinone and quercetin induce enhanced apoptosis in non-small cell lung cancer in combination through the Bax/Bcl2 cascade
- in-vitro, Lung, NA
"highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >Apoptosis↑,
114- VitC,  QC,    Chemoprevention of prostate cancer cells by vitamin C plus quercetin: role of Nrf2 in inducing oxidative stress
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
"highlight2" >GPx↓, "highlight2" >GSR↓, "highlight2" >NQO1↓, "highlight2" >NRF2↓, "highlight2" >ROS↑,
3108- VitC,  QC,    The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, Lung, A549
"highlight2" >NRF2↓, "highlight2" >HO-1↓, "highlight2" >ROS↑, "highlight2" >NRF2⇅,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 210

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

NA?, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 2,   Ferroptosis↑, 1,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 9,   GSH↑, 3,   GSH∅, 1,   GSR↓, 1,   GSR↑, 1,   H2O2↓, 1,   H2O2↑, 2,   i-H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   Iron↓, 1,   lipid-P↓, 2,   MDA↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 3,   NRF2⇅, 1,   p‑NRF2↓, 1,   OXPHOS↝, 1,   p66Shc↓, 1,   PrxI∅, 1,   PrxII↑, 1,   PrxII∅, 1,   ROS↓, 8,   ROS↑, 51,   ROS⇅, 9,   ROS∅, 2,   mt-ROS↑, 1,   SOD↑, 4,   TAC↑, 2,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 3,   ATP↓, 3,   ATP↝, 1,   BCR↓, 1,   CDC16↓, 1,   EGF↓, 2,   FGFR1↓, 1,   MEK↓, 1,   p‑MEK↓, 1,   mitResp↓, 1,   MMP↓, 20,   OCR↓, 1,   p‑p42↑, 1,   Raf↓, 4,   XIAP↓, 3,   XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   AKT1↓, 1,   AMACR↓, 1,   AMPK↑, 1,   cMyc↓, 10,   ECAR↓, 1,   FAO↓, 1,   FASN↓, 1,   GlucoseCon↓, 5,   Glycolysis↓, 7,   HK2↓, 6,   lactateProd↓, 7,   LDH↑, 2,   LDHA↓, 3,   NADPH↓, 1,   PDK3↓, 1,   PFKP?, 1,   PI3K/Akt↓, 9,   PI3K/Akt⇅, 1,   PI3k/Akt/mTOR↓, 3,   PKM2↓, 4,   PPARγ↑, 1,   SLC1A5↓, 1,   SREBP1↓, 2,  

Cell Death ⓘ

Akt↓, 17,   p‑Akt↓, 7,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 35,   ASK1↑, 1,   aSmase↝, 1,   BAD↓, 3,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 25,   Bax:Bcl2↑, 4,   Bcl-2↓, 21,   Bcl-2↑, 1,   Bcl-xL↓, 4,   Bcl-xL↑, 1,   BIM↑, 1,   Casp↑, 2,   Casp1↑, 1,   Casp10↑, 3,   Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 29,   cl‑Casp3↑, 2,   Casp7↑, 5,   Casp8↑, 8,   Casp9↑, 18,   cl‑Casp9↑, 2,   CBP↑, 1,   cFLIP↓, 5,   Chk2↑, 1,   CK2↓, 1,   CSR1↑, 1,   Cyt‑c↑, 12,   Diablo↑, 2,   DR4↑, 1,   DR5↓, 1,   DR5↑, 7,   Endon↑, 2,   Fas↓, 1,   Fas↑, 2,   FasL↑, 1,   Ferroptosis↑, 1,   IAP1↓, 1,   iNOS↓, 4,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 4,   MAPK↑, 4,   MAPK↝, 1,   Mcl-1↓, 3,   MDM2↓, 1,   p27↑, 1,   p38↓, 3,   p38↑, 3,   PDCD4↑, 1,   PUMA⇅, 1,   survivin↓, 7,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAILR↑, 2,   TumCD↑, 4,  

Kinase & Signal Transduction ⓘ

AMPKα↓, 1,   AMPKα↑, 2,   CDC7↓, 1,   HER2/EBBR2↓, 2,   RET↓, 1,   Sp1/3/4↓, 2,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 2,   cJun↑, 1,   EZH2↓, 2,   H3↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 2,   miR-21↓, 3,   miR-21↑, 1,   miR-27a-3p↓, 1,   other↓, 4,   other↑, 2,   pRB↓, 1,   p‑pRB↓, 1,   Shc↓, 1,   SPP1↓, 1,   tumCV↓, 15,  

Protein Folding & ER Stress ⓘ

c-ATF6↑, 1,   ATFs↑, 1,   CHOP↓, 1,   CHOP↑, 7,   p‑eIF2α↓, 1,   ER Stress↑, 6,   GRP78/BiP↑, 7,   Hsc70↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 3,   HSP72↓, 1,   HSP72↑, 1,   HSP90↓, 3,   HSPs↓, 2,   IRE1↑, 1,   p‑IRE1↓, 1,   NQO2↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   BNIP3↑, 1,   LC3B-II↑, 2,   SESN2↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

ATM↓, 1,   BRCA1↑, 1,   CUL4B↑, 1,   DFF45↑, 2,   DNA-PK↓, 1,   DNAdam↑, 6,   DNAdamC↑, 1,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 6,   G9a↓, 1,   MGMT↓, 1,   NKX3.1↓, 2,   NKX3.1↑, 1,   P53↓, 1,   P53↑, 15,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 8,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 4,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 8,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 8,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 20,   cycE/CCNE↓, 5,   cycF↓, 1,   E2Fs↓, 3,   P21↓, 2,   P21↑, 6,   RB1↑, 1,   p‑RB1↓, 1,   TAp63α↑, 1,   TumCCA↓, 1,   TumCCA↑, 31,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 2,   AR-FL↓, 1,   AR-V7↑, 1,   CD133↓, 4,   CD24↓, 2,   CD44↓, 4,   cDC2↓, 2,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 14,   Diff↓, 1,   EMT↓, 15,   EP300↑, 1,   EpCAM↓, 2,   ERK↓, 5,   ERK↑, 3,   ERK↝, 1,   p‑ERK↓, 5,   FBXW7↝, 1,   FGF↓, 2,   FGFR2↓, 1,   FLT3↓, 1,   FOXO3↑, 1,   Gli1↓, 1,   GSK‐3β↓, 3,   H3K27ac↓, 1,   HDAC↓, 4,   HDAC1↓, 1,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC4↓, 2,   HDAC6↓, 1,   HH↓, 2,   HMTs↓, 2,   IGF-1↓, 2,   IGF-1R↓, 5,   IGF-2↓, 2,   IGFBP3↑, 4,   Jun↓, 1,   Let-7↑, 1,   mTOR↓, 13,   p‑mTOR↓, 1,   Nanog↓, 2,   NF2↑, 1,   NOTCH↓, 2,   NOTCH1↓, 3,   NRAS↓, 1,   OCT4↓, 1,   P70S6K↓, 2,   PI3K↓, 12,   p‑PI3K↓, 1,   PTEN↑, 5,   RAS↓, 5,   SCF↓, 1,   Shh↓, 2,   STAT↓, 2,   STAT3↓, 9,   STAT3↑, 1,   p‑STAT3↓, 2,   STAT4↓, 1,   TCF↓, 1,   TOP2↓, 2,   TumCG↓, 15,   Wnt↓, 1,   Wnt/(β-catenin)↓, 3,  

Migration ⓘ

5LO↓, 1,   ACTA2↓, 1,   AntiAg↓, 1,   Ca+2↑, 5,   Ca+2↝, 1,   CDK4/6↓, 1,   CLDN2↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 2,   E-cadherin↓, 1,   E-cadherin↑, 6,   EphB4↓, 1,   FAK↓, 2,   GnT-V↝, 1,   heparanase↝, 1,   hnRNPA1↓, 2,   Ki-67↓, 5,   KRAS↓, 1,   LEF1↓, 3,   MALAT1↓, 1,   MET↓, 1,   miR-133a-3p↑, 1,   miR-148a↓, 1,   miR-19b↓, 1,   miR-206↑, 1,   MMP-10↓, 1,   MMP2↓, 13,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 8,   MMP9:TIMP1↓, 1,   MMPs↓, 9,   MSH2↑, 1,   MUC1↓, 1,   N-cadherin↓, 5,   NM23↑, 1,   p‑p44↓, 1,   p‑p44↑, 1,   PDGF↓, 3,   PKA↓, 1,   PKCδ↓, 2,   Rac1↓, 1,   RAGE↓, 2,   ROCK1↑, 1,   Slug↓, 6,   Snail↓, 7,   TET1↑, 2,   TGF-β↓, 5,   TIMP1↑, 1,   TIMP2↑, 2,   TIMP3↑, 1,   TSC1↑, 1,   TSP-1↑, 4,   TumCI↓, 13,   TumCMig↓, 13,   TumCP↓, 22,   TumCP↑, 1,   TumMeta↓, 8,   Twist↓, 5,   uPA↓, 4,   uPAR↓, 2,   Vim↓, 8,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 10,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 10,   FLT4↓, 1,   HIF-1↓, 1,   HIF-1↑, 1,   Hif1a↓, 6,   NO↓, 2,   VEGF↓, 9,   VEGFR2↓, 4,   ZBTB10↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 4,   NHE1↓, 1,   P-gp↓, 5,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 11,   CRP↓, 3,   CXCR4↓, 4,   IFN-γ↓, 2,   IKKα↓, 2,   IL10↓, 4,   IL1β↓, 2,   IL6↓, 7,   IL8↓, 2,   Inflam↓, 3,   IκB↓, 1,   JAK↓, 2,   JAK2↓, 2,   JAK3↓, 1,   Macrophages↓, 1,   Neut↓, 1,   NF-kB↓, 10,   p65↓, 1,   PSA↓, 4,   SOCS1↑, 1,   T-Cell↑, 2,   TLR4↓, 1,   TNF-α↓, 7,  

Cellular Microenvironment ⓘ

PLC↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 9,   AR↑, 1,   CDK6↓, 2,   COMT↓, 4,   CYP19↓, 1,   ER(estro)↑, 1,   FKBP5↓, 1,  

Drug Metabolism & Resistance ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 7,   ChemoSen↑, 12,   ChemoSen↝, 1,   eff↓, 3,   eff↑, 23,   MDR1↓, 1,   MRP1↓, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

AR↓, 9,   AR↑, 1,   BRCA1↑, 1,   CRP↓, 3,   EGFR↓, 10,   EZH2↓, 2,   HEC1↓, 1,   HemoG↓, 1,   HER2/EBBR2↓, 2,   IL6↓, 7,   Ki-67↓, 5,   KRAS↓, 1,   LDH↑, 2,   NOS2↓, 1,   PSA↓, 4,   RAGE↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 5,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 4,   chemoPv↑, 6,   hepatoP↑, 1,   IMPDH1↓, 1,   IMPDH2↓, 1,   OS?, 1,   OS↑, 2,   PRAS40↓, 1,   Risk↓, 1,   TGFβR1↑, 1,   toxicity↓, 2,   TumVol↓, 7,   UBE2C↓, 1,  
Total Targets: 451

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   antiOx↓, 2,   antiOx↑, 20,   Catalase↑, 8,   Copper↓, 1,   Fenton↓, 1,   GPx↑, 6,   GSH↑, 8,   GSH⇅, 1,   H2O2↓, 1,   HO-1↑, 7,   Iron↓, 1,   Keap1↓, 3,   lipid-P↓, 11,   MDA↓, 10,   MDA↑, 1,   MPO↓, 1,   NOX4↓, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 16,   ROS↓, 31,   ROS↑, 1,   ROS⇅, 1,   SOD↑, 10,   SOD2↑, 1,   TAC↑, 1,   TAC∅, 1,   Trx↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↓, 1,   IronCh↑, 3,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 2,   MMP↑, 4,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   ALDOA↑, 1,   AMP↓, 1,   AMPK↑, 3,   CREB↑, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   GPI↑, 1,   HK2↓, 1,   HK2↑, 1,   lactateProd↓, 1,   LDH↓, 2,   LDHA↑, 1,   LDL↓, 1,   NADPH↓, 2,   PFKL↑, 1,   PFKP↓, 1,   PKM1↑, 1,   PKM2↓, 3,   PONs↑, 1,   PPARα↑, 1,   SIRT1↓, 1,   SIRT1↑, 6,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 4,   p‑Akt↑, 1,   Apoptosis↓, 5,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3↓, 1,   GRP58↓, 1,   iNOS↓, 5,   p‑JNK↓, 1,   MAPK↓, 3,   MAPK↑, 1,   p38↓, 1,   p38↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 1,  

Protein Folding & ER Stress ⓘ

ATF6↓, 2,   CHOP↓, 2,   ER Stress↓, 6,   GRP78/BiP↓, 5,   IRE1↓, 2,   PERK↓, 1,   p‑PERK↓, 1,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

MitoP↑, 1,  

DNA Damage & Repair ⓘ

P53↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   PI3K↓, 1,   PI3K↑, 4,   STAT3?, 1,   p‑STAT3↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 2,   AP-1↓, 2,   Ca+2↓, 2,   CDK5↓, 1,   PKCδ↓, 1,   p‑SMAD2↓, 1,   SPARC↓, 1,   TXNIP↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 1,   CLDN5↑, 1,   EGFR↓, 1,   Hif1a↑, 2,   NO↓, 1,   PDI↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 8,   CRP↓, 1,   CXCL1↓, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 7,   IL6↓, 8,   IL8↓, 2,   Inflam↓, 26,   JAK2↑, 1,   MCP1↓, 1,   NF-kB↓, 12,   p65↓, 1,   TLR4↑, 1,   TNF-α↓, 10,  

Synaptic & Neurotransmission ⓘ

AChE↓, 6,   BChE↓, 1,   BDNF↑, 2,   tau↓, 1,   p‑tau↓, 2,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 6,   BACE↓, 2,   NLRP3↓, 4,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 10,   BioAv↝, 1,   BioEnh↑, 3,   Dose↑, 1,   eff↓, 1,   eff↑, 4,   eff↝, 2,   Half-Life↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BG↓, 1,   BP↓, 3,   CRP↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   IL6↓, 8,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 1,   cardioP↑, 10,   cognitive↑, 8,   hepatoP↑, 3,   memory↑, 4,   motorD↑, 2,   neuroP↑, 17,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   Weight↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Sepsis↓, 3,  
Total Targets: 175

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:140  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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