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| Regular physical activity has been shown to influence cancer risk, progression, and survivorship. While exercise is not a cure for cancer, extensive research indicates that it can help reduce the risk of developing certain types of cancer and improve outcomes and quality of life for those diagnosed. -Lowering the levels of hormones levels. -Preventing high blood levels of insulin. -Regular physical activity leads to decreased levels of inflammatory markers (such as C-reactive protein and interleukin-6). -Improving immune system function (enhancing the circulation of immune cells, including natural killer cells, T lymphocytes, and macrophages) -Reducing the time it takes for food to travel through the digestive system. -Helping to prevent obesity, which is a risk factor for many cancers. -Exercise promotes the upregulation of antioxidant defenses. Exercise simultaneously modulates multiple core cancer drivers: ↓ Insulin / IGF-1 signaling ↓ Chronic inflammation (IL-6, TNF-α baseline) ↑ Immune surveillance (NK cells, CD8⁺ T cells) ↑ Mitochondrial function and mitophagy ↓ Estrogen and androgen bioavailability ↑ Circadian stability ↓ Visceral adiposity (key endocrine organ) No supplement or single molecule does this breadth of work. Exercise, fasting, and diet work by changing the environment tumors depend on — not by poisoning the tumor. Age-stratified interpretation 1. Younger / metabolically healthy adults -Baseline IGF-1: normal–high -Exercise effect: -Systemic IGF-1 ↔ or slight ↓ -IGF-1 signaling efficiency ↑ (better receptor sensitivity) -Net effect: -Less chronic growth drive -Better metabolic control ➡ This is where IGF-1 ↓ papers usually come from. 2. Older adults (≈50–60+ years) -Baseline IGF-1: low -Exercise effect: -IGF-1 ↑ (restoration toward youthful range) -Improved GH → IGF-1 axis responsiveness -Net effect: -Muscle, bone, immune maintenance -Reduced frailty and inflammation ➡ This is where IGF-1 ↑ papers come from. 3. Cancer relevance (critical distinction) -Even when circulating IGF-1 increases in older exercisers: -Tumor IGF-1 signaling still goes DOWN, because: -Insulin sensitivity improves -IGFBP balance shifts -Inflammation drops -mTOR tone is suppressed -AMPK tone is elevated So: -Host IGF-1 ↑ ≠ tumor IGF-1 signaling ↑Exercise — Cancer vs Normal Cell Effects
Exercise — Alzheimer’s Disease & Cognitive Decline
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| Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases. Caspase-1 may have both tumorigenic or antitumorigenic effects on cancer development and progression, but it depends on the type of inflammasome, methodology, and cancer. Catalase is an enzyme found in nearly all living cells exposed to oxygen. Its primary role is to protect cells from oxidative damage by catalyzing the conversion of hydrogen peroxide (H₂O₂), a potentially damaging byproduct of metabolism, into water (H₂O) and oxygen (O₂). This detoxification process is crucial because excess H₂O₂ can lead to the formation of reactive oxygen species (ROS) that damage proteins, lipids, and DNA. Catalase and Cancer Oxidative Stress and Cancer: Cancer cells often experience increased levels of oxidative stress due to rapid proliferation and metabolic changes. This stress can lead to DNA damage, promoting tumorigenesis. Catalase helps mitigate oxidative stress, and its expression can influence the survival and proliferation of cancer cells. Expression Levels in Different Cancers: Overexpression: In some cancers, such as breast cancer and certain types of leukemia, catalase may be overexpressed. This overexpression can help cancer cells survive in oxidative environments, potentially leading to more aggressive tumor behavior. Downregulation: Conversely, in other cancers, such as colorectal cancer, reduced catalase expression has been observed. This downregulation can lead to increased oxidative stress, contributing to tumor progression and metastasis. Prognostic Implications: Survival Rates: Studies have shown that high levels of catalase expression can be associated with poor prognosis in certain cancers, as it may enable cancer cells to resist apoptosis (programmed cell death) induced by oxidative stress. Some types of cancer cells have been reported to exhibit lower catalase activity, possibly increasing their vulnerability to oxidative damage under certain conditions. This vulnerability has even been exploited in some therapeutic strategies (for example, approaches that generate excess H₂O₂ or other ROS specifically targeting cancer cells have been researched). |
| 5055- | Ex, | Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes |
| - | Review, | Var, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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