Radiotherapy/Radiation / OCT4 Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱

Features:

Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.

OCT4, Octamer-binding transcription factor 4: Click to Expand ⟱

Source:

Type:

POU5F1 is a gene that encodes a transcription factor also known as Oct4.
OCT4 (Octamer-binding transcription factor 4) is a transcription factor that plays a crucial role in maintaining the pluripotency and self-renewal of embryonic stem cells. It is part of the core regulatory network that governs stem cell identity and is essential for the early stages of development.
OCT4 is often expressed in cancer stem cells, which are a subpopulation of cells within tumors that possess the ability to self-renew and drive tumorigenesis. The presence of OCT4 in these cells is associated with increased tumor aggressiveness and resistance to conventional therapies.

Scientific Papers found: Click to Expand⟱

2715-

BBR,

Rad,

Berberine Can Amplify Cytotoxic Effect of Radiotherapy by Targeting Cancer Stem Cells

in-vitro,

BC,

MCF-7

tumCV↓, OCT4↓, SOX2↓, RadioS↑, CSCs↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Transcription & Epigenetics ⓘ

tumCV↓, 1,

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1, OCT4↓, 1, SOX2↓, 1,

Drug Metabolism & Resistance ⓘ

RadioS↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: OCT4, Octamer-binding transcription factor 4

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells