Radiotherapy/Radiation / DNArepair Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
-Hypoxia (low oxygen levels) within tumors is a major cause of resistance to radiotherapy


DNArepair, DNA repair: Click to Expand ⟱
Source: HalifaxProj(enhance)
Type:
DNA repair is a crucial cellular process that maintains the integrity of the genome by correcting damage that can occur due to various factors, including environmental stress, radiation, and normal metabolic activities.
Radiation and Chemotherapy: These treatments often work by inducing DNA damage, and cancer cells with defective repair mechanisms may be more susceptible to these therapies.
Scientific Papers found: Click to Expand⟱
7651- HPT,  Rad,    Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner
- in-vitro, Var, NA
RadioS↑, DNArepair↓, Dose↑,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
7575- HPT,  Rad,  Chemo,  immuno,    From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
RadioS↑, ChemoSen↑, Imm↑, BloodF↑, Hypoxia↓, Dose↝, DNArepair↓, e-pH↓,
5038- SAS,  Rad,    Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma
- in-vivo, Melanoma, B16-F10
xCT/SLC7A11↓, ROS↑, RadioS↓, GSH↓, selectivity↑, DNArepair↓, TumCCA↑, H2O2↑, Dose↝,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LC↑, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   H2O2↑, 1,   ROS↑, 1,   xCT/SLC7A11↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↓, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↑, 1,   Hypoxia↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   e-pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 3,   RadioS↓, 1,   RadioS↑, 3,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 2,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: DNArepair, DNA repair
4 Radiotherapy/Radiation
3 Hyperthermia
1 Chemotherapy
1 immunotherapy
1 Sulfasalazine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:84  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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