Gossypol / lactateProd Cancer Research Results

Gos, Gossypol: Click to Expand ⟱

Features:

Gossypol is a natural compound found in cottonseed, a byproduct of the cotton industry. It has been studied for its potential anti-cancer properties. Research has shown that gossypol can inhibit the growth of various types of cancer cells, including breast, prostate, lung, and colon cancer.

Gossypol's anti-cancer effects are thought to be due to its ability to:

-Inhibit the activity of certain enzymes involved in cancer cell growth and survival
-Induce apoptosis (cell death) in cancer cells
-Inhibit the formation of new blood vessels that feed cancer cells (anti-angiogenesis)
-Modulate the immune system to attack cancer cells

Some studies have also suggested that gossypol may have synergistic effects when combined with other anti-cancer agents, such as chemotherapy and radiation therapy.

lactateProd, lactate production: Click to Expand ⟱

Source:

Type:

Lactate production has been linked to cancer development and progression. In normal conditions, lactate is produced in cells through a process called glycolysis, which breaks down glucose to generate energy. However, in cancer cells, this process is often upregulated, leading to increased lactate production, even in the presence of oxygen. This phenomenon is known as the Warburg effect.

-Lactate is the end product of glycolysis and induces TGFβ1 upregulation and the acidic microenvironment.

Scientific Papers found: Click to Expand⟱

941-

Gos,

Rad,

The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis

in-vivo,

NA,

mice, injection to mice starting at week 4 postirradiation at a dose of 5 mg/kg in 30 μl volume

lactateProd↓, other↓, TGF-β↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

lactateProd↓, 1,

Transcription & Epigenetics ⓘ

other↓, 1,

Migration ⓘ

TGF-β↓, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: lactateProd, lactate production

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells