Ras-selective lethal 3 / TBARS Cancer Research Results

RSL3, Ras-selective lethal 3: Click to Expand ⟱

Features: ferroptosis inducer

RSL3 (Ras-selective lethal 3) is a small molecule that has been shown to have anti-cancer properties. It is a ferroptosis inducer, which means that it induces a type of cell death that is characterized by the accumulation of iron and the production of reactive oxygen species (ROS).

RSL3 works by inhibiting the activity of the enzyme GPX4 (glutathione peroxidase 4), which is involved in the regulation of lipid peroxidation and the maintenance of cellular redox balance. In cancer cells, GPX4 is often overexpressed, and RSL3's inhibition of this enzyme leads to an accumulation of lipid peroxides and a disruption in cellular redox balance.

TBARS, Thiobarbituric Acid Reactive Substances: Click to Expand ⟱

Source:

Type: measure

TBARS (Thiobarbituric Acid Reactive Substances) is a measure of lipid peroxidation, which is the oxidative degradation of lipids. Lipid peroxidation is a process in which free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs), leading to cell damage.

Research has shown that TBARS levels are often elevated in cancer patients. This is because cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, which can lead to increased lipid peroxidation.

Scientific Papers found: Click to Expand⟱

727-

Bor,

RSL3,

erastin,

Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy

in-vitro,

Liver,

HepG2

ROS↑, GSH↓, TBARS↑, Ferroptosis↑, ChemoSen↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1, GSH↓, 1, ROS↑, 1, TBARS↑, 1,

Cell Death ⓘ

Ferroptosis↑, 1,

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TBARS, Thiobarbituric Acid Reactive Substances

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells