Estrogen / GLS Cancer Research Results

Est, Estrogen: Click to Expand ⟱

Features:

Estrogen is a hormone that plays a crucial role in the development and progression of various types of cancer. (ER-positive cancers).
ER-positive cancers tend to have a better prognosis than ER-negative cancers, as they are more likely to respond to hormone therapy.

Negative effects of estrogen supplements on cancer:
Breast cancer: Estrogen supplements can increase the risk of breast cancer, particularly in postmenopausal women. This is because estrogen can stimulate the growth of estrogen receptor-positive (ER+) breast cancer cells.
Endometrial cancer: Estrogen supplements can increase the risk of endometrial cancer, particularly in women who have not had a hysterectomy. This is because estrogen can stimulate the growth of endometrial cells, leading to an increased risk of cancer.
Ovarian cancer: Some studies suggest that estrogen supplements may increase the risk of ovarian cancer, although the evidence is not conclusive.

Positive effects of estrogen supplements on cancer:
Colorectal cancer: Some studies suggest that estrogen supplements may reduce the risk of colorectal cancer, particularly in postmenopausal women.
Prostate cancer: Estrogen supplements may have a protective effect on prostate cancer, although the evidence is not conclusive.

GLS, glutaminase: Click to Expand ⟱

Source:

Type:

Glutaminase is an enzyme that plays a crucial role in the metabolism of glutamine, an amino acid that is often utilized by cancer cells for growth and proliferation. In many cancers, including glioblastoma, leukemia, and certain types of solid tumors, glutamine metabolism is upregulated, allowing cancer cells to meet their increased energy and biosynthetic demands.
Glutamine Addiction: Many cancer cells exhibit a phenomenon known as "glutamine addiction," where they rely heavily on glutamine for survival and growth. This is particularly evident in rapidly proliferating tumors.
Glutaminase catalyzes the conversion of glutamine to glutamate, which can then enter various metabolic pathways, including the tricarboxylic acid (TCA) cycle. This process is essential for providing energy and building blocks for nucleotides and amino acids.
Inhibitors of glutaminase are being investigated in preclinical and clinical studies as a means to starve cancer cells of glutamine and inhibit their growth.

GLS expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in supporting the metabolic needs of cancer cells.

Scientific Papers found: Click to Expand⟱

975-

Est,

Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism

vitro+vivo,

UEC,

GLS↑, cMyc↑, GlutMet↑, tumCV↑, TumAuto↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

cMyc↑, 1, GLS↑, 1, GlutMet↑, 1,

Transcription & Epigenetics ⓘ

tumCV↑, 1,

Autophagy & Lysosomes ⓘ

TumAuto↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GLS, glutaminase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells