Estrogen / GlutMet Cancer Research Results

Est, Estrogen: Click to Expand ⟱

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Estrogen is a hormone that plays a crucial role in the development and progression of various types of cancer. (ER-positive cancers).
ER-positive cancers tend to have a better prognosis than ER-negative cancers, as they are more likely to respond to hormone therapy.

Negative effects of estrogen supplements on cancer:
Breast cancer: Estrogen supplements can increase the risk of breast cancer, particularly in postmenopausal women. This is because estrogen can stimulate the growth of estrogen receptor-positive (ER+) breast cancer cells.
Endometrial cancer: Estrogen supplements can increase the risk of endometrial cancer, particularly in women who have not had a hysterectomy. This is because estrogen can stimulate the growth of endometrial cells, leading to an increased risk of cancer.
Ovarian cancer: Some studies suggest that estrogen supplements may increase the risk of ovarian cancer, although the evidence is not conclusive.

Positive effects of estrogen supplements on cancer:
Colorectal cancer: Some studies suggest that estrogen supplements may reduce the risk of colorectal cancer, particularly in postmenopausal women.
Prostate cancer: Estrogen supplements may have a protective effect on prostate cancer, although the evidence is not conclusive.

GlutMet, Glutamine metabolism: Click to Expand ⟱

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Glutamine metabolism plays a significant role in cancer biology, as many cancer cells exhibit altered metabolic pathways to support their rapid growth and proliferation.
Glutamine is a non-essential amino acid that serves as a vital nutrient for many cells, including cancer cells. It is involved in various metabolic processes, including protein synthesis, nucleotide synthesis, and energy production.
Warburg Effect: Cancer cells often rely on aerobic glycolysis (the Warburg effect) for energy production, even in the presence of oxygen. Glutamine metabolism can complement this process by providing intermediates for the tricarboxylic acid (TCA) cycle, which is crucial for energy production and biosynthesis.
Inhibitors of glutaminase (an enzyme that converts glutamine to glutamate) and other metabolic pathways are being explored in preclinical and clinical settings.

Key Enzymes in Glutamine Metabolism
Glutaminase (GLS)
Glutamate Dehydrogenase (GLUD)
Glutamine Synthetase (GS)
Asparagine Synthetase (ASNS)
Aminotransferases (e.g., GPT, GOT)

The expression of enzymes involved in glutamine metabolism is often elevated in various cancers and is generally associated with poorer prognosis.

Scientific Papers found: Click to Expand⟱

975-

Est,

Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism

vitro+vivo,

UEC,

GLS↑, cMyc↑, GlutMet↑, tumCV↑, TumAuto↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

cMyc↑, 1, GLS↑, 1, GlutMet↑, 1,

Transcription & Epigenetics ⓘ

tumCV↑, 1,

Autophagy & Lysosomes ⓘ

TumAuto↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GlutMet, Glutamine metabolism

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells