cannabidiolic acid / SHARP Cancer Research Results

CBDA, cannabidiolic acid: Click to Expand ⟱

Features:

Cannabidiolic acid (CBDA) is the acidic precursor of cannabidiol (CBD) found in Cannabis sativa.
- Note that although CBDA shares some pharmacological properties with CBD, its profile can differ due to its carboxylic acid group, which may affect its bioavailability, receptor binding, and overall cellular uptake.

Cannabidiolic acid (CBDA) shows promise in modulating several pathways that are relevant to cancer biology—including COX-2 inhibition, PPARγ activation, apoptosis induction, and anti-inflammatory effects. In parallel, CBDA may offer additional benefits such as anti-emetic, anxiolytic, and potential neuroprotective effects. However, the current body of research is largely preclinical. CBDA is often found in raw cannabis plants and does not undergo decarboxylation like its more well-known counterpart cannabidiol (CBD).
Unlike the tetrahydrocannabinol (THC) found in cannabis, CBDA is non-psychoactive. This means it does not cause the "high" or altered state of mind commonly associated with cannabis use.
CBDA does not directly bind to the primary cannabinoid receptors (CB1 and CB2) in the brain that are responsible for psychoactive effects.

Pathways:
-CBDA may modulate receptors beyond the classical CB1 and CB2, such as transient receptor potential (TRP) channels (e.g., TRPV1) and possibly the orphan receptor GPR55, thereby influencing cell signaling, calcium homeostasis, and related pathways.
-Inhibition of cyclooxygenase enzymes (COX)
-Mitochondrial dysfunction and the activation of caspases
-Modulation of the PI3K/Akt Pathway
-Affect the MAPK family of pathways, including ERK, JNK, and p38 kinases
-Modulating matrix metalloproteinases (MMPs)
-As an antioxidant (or under some conditions a pro-oxidant)

SHARP, SHARP1/BHLHE41: Click to Expand ⟱

Source:

Type:

SHARP1/BHLHE41 is a basic helix-loop-helix (bHLH) transcription factor that regulates gene expression by binding to E-box elements in target gene promoters.
– A suppressor of breast cancer metastasis
– It generally functions as a transcriptional repressor, controlling the expression of genes involved in circadian rhythm, differentiation, and metabolism.
• Circadian Rhythm and Metabolism:
– SHARP1 plays a role in maintaining circadian rhythm by modulating the oscillatory expression of clock genes.
– Through these regulatory networks, it also influences energy metabolism and cell-cycle control.

– Some studies report downregulation of SHARP1 in certain cancers, which may correlate with loss of its differentiation and growth-suppressive functions.
– In other contexts, SHARP1 may be upregulated, potentially reflecting an adaptive response to the altered microenvironment or a compromised circadian program in tumors.

Scientific Papers found: Click to Expand⟱

1081-

CBDA,

Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells

in-vitro,

BC,

MDA-MB-231

25uM 48hr

COX2↓, Id1↓, SHARP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

SHARP↑, 1,

Proliferation, Differentiation & Cell State ⓘ

Id1↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: SHARP, SHARP1/BHLHE41

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells