sericin / Casp9 Cancer Research Results

sericin, sericin: Click to Expand ⟱
Features:
Sericin is a silk protein primarily obtained from the silkworm Bombyx mori and has attracted interest for its various biological properties. Some studies have investigated the potential anticancer properties of sericin.

-Sericin exhibits antioxidant properties, which may help protect cells against oxidative stress. Oxidative stress is known to contribute to the development and progression of cancer, so antioxidants are often considered beneficial in preventive strategies.
-Sericin’s anti-inflammatory effects might help reduce inflammation-related damage and potentially slow down processes that can lead to carcinogenesis.
Casp9, Caspase-9: Click to Expand ⟱
Source:
Type:
Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.
Scientific Papers found: Click to Expand⟱
1678- PBG,  5-FU,  sericin,    In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway
- in-vitro, CRC, Caco-2 - in-vivo, NA, NA
PI3K↓, Akt↓, mTOR↓, TumCP↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, ROS↓, FOXO1↑, *toxicity∅, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO1↑, 1,   mTOR↓, 1,   PI3K↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Casp9, Caspase-9
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:282  Target#:45  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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